ImmunIGy: A Novel Pen-side Test for Checking Calf Immune Status, to increase the efficiency of beef production through supply chain feedback and improved management

ImmunIGy：一种用于检查小牛免疫状态的新型栏边测试，通过供应链反馈和改进管理来提高牛肉生产效率

• 批准号: 10052523
• 金额: $ 20.63万
• 依托单位: SYNERGY FARM HEALTH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10052523
• 关键词: ImmunIGy; Novel; Pen; side; Test

Serum concentration of IgG in neonatal calves is a direct marker of the level of passive transfer of maternal antibody from colostrum. There is substantial evidence that successful passive transfer is associated with decreased morbidity and mortality rates, improved growth rates, feed conversion and lifetime productive capacity, whether the calf is destined to produce milk or enter the beef supply chain. As such, successful passive transfer is a key driver of economic and environmental efficiency on both dairy and beef farms rearing calves sourced from dairy units.ImmunIGy is a pen-side diagnostic test for measuring IgG in calves. It is novel for 2 reasons: firstly it is a Lateral Flow Test which can be carried out by the farmer, pen-side, and secondly the sample can be obtained by the farmer using a lancet on an insensitive part of the calf's nose. Hence the result can be obtained cheaply in the space of a few minutes.The project aims are to ;(a) Confirm that the output of the ImmunIGy test correlates with the current gold standard for measuring IgG, which will confirm its value for use in calves less than a week of age. (b) Determine if the measurement of IgG at collection centres for beef calves from the dairy herd can be used to predict future performance, both alone and when used to improve the function of a pre-existing Calf Algorithm. Such testing can drive improved efficiency of beef production via direct feedback to farms supplying calves with insufficient maternal immunity, pricing differentials and via bespoke management of calves according to their performance prediction. (c) Incorporate the algorithm into an App which will allow calf rearers to test calves on entry, enter the data to predict calf performance and put in place differential management practices, such as separate groups or a different threshold of disease prevalence before implementing antibiotic therapy. (d) Train the participating farmers in the use of the test, the App and the data that they need to provide whilst receiving feedback on its usability.

新生犊牛血清 IgG 浓度是初乳中母源抗体被动转移水平的直接标志。有大量证据表明，成功的被动转移与降低发病率和死亡率、提高生长率、饲料转化率和终生生产能力相关，无论小牛是注定要产奶还是进入牛肉供应链。因此，成功的被动转移是饲养来自乳制品单位的小牛的奶牛场和肉牛场经济和环境效率的关键驱动力。ImmunIGy 是一种用于测量小牛 IgG 的栏边诊断测试。它的新颖性有两个原因：首先，它是一种横向流动测试，可以由农民在栏边进行，其次，农民可以使用刺血针在小牛鼻子的不敏感部分获取样本。因此，可以在几分钟内廉价地获得结果。该项目的目标是；(a) 确认 ImmunIGy 测试的输出与当前测量 IgG 的金标准相关，这将确认其在以下领域的使用价值：不到一周大的小牛。 (b) 确定奶牛群肉牛采集中心的 IgG 测量是否可用于预测未来的表现，无论是单独使用还是用于改进现有小牛算法的功能。此类测试可以通过直接反馈给供应母体免疫力不足的小牛的农场、定价差异以及根据小牛的性能预测进行定制管理来提高牛肉生产效率。 (c) 将算法纳入应用程序，允许犊牛饲养者在进入时对犊牛进行测试，输入数据以预测犊牛性能并实施差异化管理实践，例如在实施抗生素治疗之前分开分组或不同的疾病流行阈值。 (d) 对参与的农民进行使用测试、应用程序和他们需要提供的数据的培训，同时接收有关其可用性的反馈。