Core A - Administrative

核心 A - 行政

• 批准号: 10331681
• 负责人: Berislav V Zlokovic
• 金额: $ 24.99万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10331681
• 关键词: Agreement; Alzheimer' s Disease; Alzheimer' s disease risk; Applied Research; Arizona; Blood; Brain; Businesses; California; Charge; Clinic; Clinical; Cognitive; Collaborations; Collection; Communication; Communities; Complement; Data Analyses; Data Protection; Dementia; Development; Disputes; Documentation; Education; Ensure; Environment; Ethics; Evaluation; Exclusion Criteria; Experimental Designs; Funding; Funding Opportunities; Goals; Human Resources; Huntington Disease; Income; Informatics; Institutes; Institution; Instruction; Intellectual Property; Lead; Leadership; Los Angeles; MRI Scans; Measures; Medical Research; Modeling; Molecular Medicine; Monitor; Neurology; Neuropsychology; Paper; Participant; Persons; Program Development; Quality Control; Reporting; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Science; Scotland; Series; Site; Structure; Sum; Technology; Testing; Universities; Vascular Dementia; Washington; clinical center; data sharing; dementia risk; design; diagnostic criteria; genetic risk factor; meetings; member; mild cognitive impairment; neurogenetics; neuroimaging; neurophysiology; neurovascular; open data; programs; psychologic; screening; success; web site

CORE A – PROJECT SUMMARY/ABSTRACT This is a continuing program project with multiple projects, cores, institutions and investigators from the Zilkha Neurogenetic Institute, Stevens Neuroimaging and Informatics Institute, Alzheimer’s Disease Research Center (ADRC), University of Southern California, Los Angeles, CA; Washington University Knight ADRC and Department of Neurology, St. Louis, MO; Huntington Medical Research Institutes, Pasadena, CA; Banner Alzheimer’s Institute and MayoClinic, Arizona; Department of Psychological Science, UC Irvine; and Department of Molecular Medicine, the Scripps Research Institute; and Centre for Clinical Brain Sciences, University of Edinburgh, Scotland will also join the program. The P01 has and will continue to function as an integrated whole far greater than the sum of its parts. Each project and core complements the others so that a synergistic relationship among them is achieved with a common focus on goals of the program, namely to test the neurovascular hypothesis of AD. The Administrative Core is structured to insure that this program functions as efficiently, productively and transparently as possible. The goals of Core A remain designed to provide effective scientific and administrative leadership for the program and ensure effective communications across projects and cores. Given that this program project has multiple sites and linkages to other funded efforts, it is essential that we manage these efforts to insure harmonization of inclusion/exclusion criteria, clinical and neuropsychological evaluations, and diagnostic criteria for cognitively unimpaired, mild cognitive impairment and dementia. Core A facilitates these goals with committees, documentation, website resources and internal and external (SAB) reviews. The Aims of this Core reflect the commitment of the MPIs, Drs. Zlokovic and Toga, to provide the scientific and administrative leadership for the program consisting of 3 research projects and 3 cores, which are all integrated and use complementary approaches, technologies and analyses focused on the program project’s wide aims as described in the Overview. The Aims of Core A are: 1. To provide scientific and administrative leadership to ensure unified and consistent participant screening and enrolment across different participating sites; transparent communication across projects, cores, Co-Is and SAB members; and open data sharing among all the Co-Is, their respective clinical and scientific personnel across different institutions as well as the wider scientific community. 2. To track milestones and metric measures for the program as a whole and for all projects and cores, we will maintain internal quality control of research and hold monthly meetings of all PLs and CLs and Co-Is, quarterly meetings of subcommittees from AIM 1 and ad hoc and annual evaluation meetings with our SAB members to effectively monitor development of the program and maintain high-quality scientific progress. 3. To contribute to education. 4. To utilize business models to efficiently manage the program’s business activities including management of day-to-day activities, contractual agreements, allocation of funds, and regular income/expense reports.

核心A - 项目摘要/摘要 这是一个持续的计划项目，来自多个项目，核心，机构和调查人员 Zilkha神经遗传学研究所，史蒂文斯神经影像学研究所，阿尔茨海默氏病研究 中心（ADRC），南加州大学，加利福尼亚州洛杉矶；华盛顿大学骑士ADRC和 密苏里州圣路易斯神经病学系；亨廷顿医学研究机构，加利福尼亚州帕萨迪纳；横幅 阿尔茨海默氏症研究所和亚利桑那州Mayoclinic；加州大学尔湾分校心理科学系；和部门 Scripps研究所的分子医学；和临床脑科学中心，大学 苏格兰爱丁堡也将加入该计划。 P01拥有并将继续充当整体的整体 远大于其部分的总和。每个项目和核心都符合其他项目，以使协同作用 他们之间的关系是通过对计划的目标的共同关注而实现的，即测试 AD的神经血管假设。管理核心的结构是确保该程序的功能 有效，有效和透明。核心A的目标仍然旨在提供有效 该计划的科学和行政领导，并确保跨项目的有效沟通 和核心。鉴于该计划项目具有多个网站和与其他资助的努力的联系，这是至关重要的 我们管理这些努力，以确保包含/排除标准，临床和 神经心理学评估和认知无度认知障碍的诊断标准 失智。核心A通过委员会，文档，网站资源和内部促进这些目标，并 外部（SAB）评论。该核心的目的反映了MPI的承诺，博士。 Zlokovic和Toga， 为该计划提供科学和行政领导，包括3个研究项目和3个核心， 这些都是整合并使用针对该计划的完整方法，技术和分析 项目的广泛目标如概述中所述。核心A的目的是：1。提供科学和 行政领导，以确保统一和一致的参与者筛选和注册不同 参与网站；跨项目，核心，共同和SAB成员透明沟通；和开放数据 在所有共同IS，各自机构的临床和科学人员之间共享 作为更广泛的科学界。 2。跟踪整个程序的里程碑和公制措施 对于所有项目和核心，我们将维持研究的内部质量控制，并举行所有人的每月会议 PLS和CLS和CO-IS，AIM 1和临时的小组委员会的季度会议以及年度评估 与我们的SAB成员会议，以有效监控该计划的开发并保持高质量 科学进步。 3。为教育做出贡献。 4。利用业务模型有效管理 计划的业务活动，包括日常活动的管理，合同协议，分配 资金和常规收入/费用报告。