Administrative Core: U19

行政核心：U19

• 批准号: 10326810
• 负责人: RICHARD G WUNDERINK
• 金额: $ 31.7万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-17 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10326810
• 关键词: Algorithms; Alveolar; American; Bioinformatics; Chest; Clinical; Communicable Diseases; Communities; Complex; Critical Care; Data; Data Analyses; Databases; Development; Doctor of Philosophy; Ensure; Funding Opportunities; Goals; Guidelines; Infection; Infectious Diseases Research; Information Dissemination; Infrastructure; Institutes; Instruction; Lead; Lung; Medical; Modeling; Monitor; National Institute of Allergy and Infectious Disease; Output; Physicians; Pneumonia; Reagent; Research; Research Personnel; Research Project Grants; Resources; Schools; Scientist; Services; Societies; Specimen; Supervision; Systems Biology; TimeLine; Training; Training Programs; Universities; base; biodefense; bioinformatics resource; computerized tools; data dissemination; data submission; database schema; experimental study; innovation; microbial; multidisciplinary; open source; outreach; outreach program; pathogen; pneumonia treatment; post-doctoral training; pre-doctoral; predictive modeling; programs; public database; repository; response; symposium; tool; treatment response; web site

Admin Core Project Summary: This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The Administrative Core will be responsible for managing, coordinating, and supervising the entire range of SCRIPT Systems Biology Center activities. As such, the Administrative Core will intersect with all internal SCRIPT investigators as well as the NIAID sponsoring agency, other Systems Biology Centers, and the broader infectious diseases and pulmonary/critical care scientific communities. The SCRIPT Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The Administrative Core will accomplish these objectives in three interrelated specific aims: AIM 1. To provide the administrative and organizational infrastructure to facilitate accomplishment of the SCRIPT goals within proposed timelines, and to disseminate the output of the Research Projects and Cores. This will include the submission of SCRIPT Systems Biology Center output to NIAID-directed public databases/repositories. AIM 2. To coordinate and integrate the two SCRIPT Systems Biology Center Research Projects. AIM 3. To organize local and external outreach programs to promote a systems biology approach to infectious pneumonia. This includes integration of the SCRIPT Systems Biology Center into current local training programs, submission of an application to Gordon Research Conference or similar conference for a research symposium on a systems biology approach to pneumonia and a proposal to the American Thoracic Society for a post graduate course on Systems Biology Approaches to Pneumonia. The major premise of the SCRIPT Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. Investigators in the Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia researchers.

管理员核心项目摘要： 这种创新的集成系统生物学应用程序旨在描述复杂的宿主/病原体相互作用 发生在肺泡水平，导致严重肺炎的治疗反应不成功。这 行政核心将负责管理，协调和监督整个脚本范围 系统生物学中心活动。因此，管理核心将与所有内部脚本相交 研究人员以及NIAID赞助机构，其他系统生物学中心以及更广泛的感染力 疾病和肺部/重症监护科学社区。脚本系统生物学中心有意 多学科，增加了相互作用的复杂性，并要求采取集中式方法来促进 实现该系统生物学中心的目标。行政核心将完成这些 目的三个相互关联的特定目的：目标1。提供行政和组织 基础设施以促进拟议时间表中实现脚本目标，并传播 研究项目和核心的产出。这将包括提交脚本系统生物学 中心输出到NIAID指导的公共数据库/存储库。目标2。协调和整合两个 脚本系统生物学中心研究项目。目标3。组织本地和外部外展计划 促进系统生物学方法来传染性肺炎。这包括集成脚本 系统生物学中心进入当前本地培训计划，向戈登研究提出申请 会议或类似的会议，就肺炎系统生物学方法进行研究研讨会 美国胸腔学会的一项针对系统生物学研究生课程的建议 肺炎。脚本系统生物学中心研究议程的主要前提是一种迭代方法 基于高吞吐量法方法的结果和结果的建模。 因此，我们预计先前的结果将推动后续实验。整合和促进这些 随后的不同核心和研究人员之间的实验将是 行政核心。行政核心中的调查人员还将确保项目生成的数据 核心以对肺炎研究人员的较大社区有用的格式传播。