Mentoring in Translational Malaria Genomics

转化疟疾基因组学指导

• 批准号: 10321555
• 负责人: Jonathan J Juliano
• 金额: $ 17.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-12 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10321555
• 关键词: Address; Admixture; Africa; African; Anti-malarial drug resistance; Antimalarials; Area; Artemisinins; Asia; Asian; Award; Bacteria; Bayesian Analysis; Biology; Chloroquine; Cholera; Clinical Sciences; Combined Modality Therapy; Communicable Diseases; Complex; Containment; Culicidae; Data; Democratic Republic of the Congo; Demographic and Health Surveys; Development; Dihydropteroate Synthase; Doctor of Philosophy; Drug resistance; Educational process of instructing; Effectiveness; Ensure; Faculty; Fellowship Program; Fostering; Funding; Future; Genes; Genetic; Genetic Recombination; Genome; Genomics; Genotype; Geography; Gills; Goals; Human; Human Genetics; Influenza; Institutes; Instruction; International; Intervention; Knowledge; Leadership; Life Cycle Stages; Malaria; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Molecular Epidemiology; Mosaicism; Natural experiment; North Carolina; Parasite resistance; Parasites; Pattern; Pharmaceutical Preparations; Phylogenetic Analysis; Plasmodium; Plasmodium falciparum; Population; Population Characteristics; Population Sizes; Positioning Attribute; Public Health Schools; Publishing; Recording of previous events; Research; Research Personnel; Research Project Grants; Resistance; Resources; Schools; Side; Southeastern Asia; Structure; Students; Sulfadoxine; Surface; Technology; Training; Translating; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; Viral; Virus; Work; career; career development; data repository; design; doctoral student; effective intervention; epidemiology study; ethnic diversity; genome sequencing; global health; human genomics; improved; insight; interest; learning strategy; medical schools; member; mid-career faculty; migration; next generation sequencing; pathogenic bacteria; pathogenic virus; patient oriented research; prevent; programs; recruit; resistance gene; resistant Plasmodium falciparum; resistant strain; skills; tool; translational genomics; whole genome

PROJECT SUMMARY Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of next generation sequencing technologies for applied genomics projects. He is an Associate Professor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to establish a major center for translational malaria research. He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control. Recently, he received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNC for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students involed in POR. The proposed K24 award will allow Dr. Juliano to develop new research skills to enhance his research expertise and mentorship by gaining skills in statistical genetics and population genomics, by learning strategies for effective leadership, and by enhancing his mentoring skills. The proposed research will establish new research opportunities to foster the career development of his trainees. To achieve his goals, Dr. Juliano will leverage the extensive training resources available at UNC, including the NC Translational and Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr. Juliano’s involvement in these programs, as well as the School of Medicine MD/PhD program and the UNC Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees, including students, fellows and junior faculty. As part of this proposal, he will receive both formal and informal guidance to develop as a mentor and also increase his participation in formal mentoring activities on campus. Central to Dr. Juliano’s research is understanding antimalarial resistance. The emergence of drug-resistant malaria parasites is a major hurdle in the control of Plasmodium falciparum, which has evolved resistance to nearly every antimalarial drug in use. Importantly, little is known about how parasite populations evolve to permit the emergence and spread of resistance. Statistical genetics and demographic inference provide a framework for understanding parasite population characteristics that impact the rate and timing of the spread of resistance. These approaches provide an opportunity to predict future paths for the spread of resistance and to help develop targeted interventions. The Demographic Inference to Study Antimalarial Resistance Migration (DISARM) study will translate advances made in statistical genetics for humans to the study of malaria parasite populations. The proposed K24 will permit Dr. Juliano to develop a research platform that is a natural extension of his previous work, represents a significant methodological advance for the study of malaria, and provides rich opportunities for direct mentorship of trainees and young faculty members.

项目摘要 乔纳森·朱利亚诺（Jonathan Juliano）博士是疟疾研究的国际认可的领导者，也是使用的先驱 用于应用基因组学项目的下一代测序技术。他是 北卡罗来纳大学教堂山分校的传染病科，在那里他帮助 建立一个主要的翻译疟疾研究中心。他拥有连续独立的NIH资金 自2010年以来。朱莉安诺（Juliano）博士致力于从事以患者为导向的研究（POR）的学术生涯，他在其中。 他的实习生解决了与疟疾控制直接相关的问题。最近，他收到了 2016年享有盛誉的2016年杰出教学奖在UNC上为他的强大教学奖 心理学员的记录，重点是传染病研究员和参与的MD/博士学位学生 por。拟议的K24奖将使Juliano博士能够发展新的研究技能以增强他的研究 通过学习，通过获得统计遗传学和人群基因组学的技能来获得专业知识和心理 有效领导的策略，并通过增强他的心理技能。拟议的研究将 建立新的研究机会来促进学员的职业发展。为了实现他的目标，博士 Juliano将利用UNC可用的广泛培训资源，包括NC翻译和 临床科学研究所，吉林斯全球公共卫生学院和医学院。博士 朱利亚诺（Juliano）参与这些计划，医学学院MD/PhD计划和UNC 传染病奖学金计划，确保他将在招募和指导培训方面处于良好状态， 包括学生，研究员和初级教师。作为该提案的一部分，他将获得正式和非正式的 发展为心理的指导，并增加他参与校园正式心理活动的参与。 朱莉安诺（Juliano）研究的核心是了解抗疟疾抗性。耐药的出现 疟疾寄生虫是控制恶性疟原虫的主要障碍，该疟原虫已进化为抗性 几乎所有正在使用的抗疟药。重要的是，关于寄生虫种群如何发展为 允许抵抗的出现和传播。统计遗传学和人口推断提供了 理解影响寄生虫种群特征的框架 反抗。这些方法为预测抵抗传播和对未来的途径提供了机会 帮助制定目标干预措施。研究抗性抗性的人群推论 迁移（解除武装）研究将把人类统计遗传学的进步转化为研究 疟疾寄生虫种群。拟议的K24将允许Juliano博士开发一个研究平台，这是一个 他以前的工作的自然扩展代表了研究的重大方法论进步 疟疾，并为受训者和年轻教职员工的直接心态提供了丰富的机会。