Mentoring in Translational Malaria Genomics

转化疟疾基因组学指导

• 批准号: 10662964
• 负责人: Jonathan J Juliano
• 金额: $ 17.32万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-12 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662964
• 关键词: Address; Africa; Africa South of the Sahara; Award; Biological Assay; Biology; Clinic; Clinical Sciences; Communicable Diseases; Communities; Complementarity Determining Regions; Complex; Country; Cross-Sectional Studies; Democratic Republic of the Congo; Detection; Development; Disease; Doctor of Philosophy; Educational process of instructing; Elements; Ensure; Environment; Equity; Evolution; Exclusion; Faculty; Fellowship Program; Fostering; Funding; Genes; Genetic; Genetic Markers; Genetic Variation; Genome; Genomics; Genotype; Geography; Gills; Goals; Hot Spot; Household; Infection; Instruction; International; Intervention; Knowledge; Leadership; Location; London; Malaria; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular; Movement; Multigene Family; North Carolina; Parasites; Pathogenesis; Pattern; Persons; Plasmodium falciparum; Population; Positioning Attribute; Postbaccalaureate; Public Health; Publishing; Research; Research Personnel; Resistance; Resolution; Resources; Risk Factors; Rural; Sampling; Schools; Site; Structure; Students; Technology; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Urbanicity; Work; Zanzibar; career; career development; college; comparative; cost effective; deep sequencing; design; doctoral student; effective intervention; experience; genome sequencing; genomic tools; improved; induced pluripotent stem cell; learning strategy; malaria infection; malaria transmission; medical schools; member; migration; next generation sequencing; patient oriented research; professor; programs; recruit; rural area; skills; targeted sequencing; tool; translational genomics; transmission process; urban setting; whole genome

PROJECT SUMMARY Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of next generation sequencing technologies for applied genomics projects. He is a Professor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to establish a major center for translational malaria research. He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control, He is recognized as an outstanding mentor, having received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNG for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students students involved in POR The proposed renewal of his K24 award will allow Dr. Juliano to develop new research skills to enhance his research expertise and mentorship by gaining skills in spatial and transmission modeling of malaria, by learning strategies for effective leadership, and by building on the mentoring skills developed in his K24. In particular, he will newly focus on skills specifically for mentoring diverse groups of trainees through both formal and informal guidance. To foster the career development of his trainees, Dr. Juliano will leverage the extensive training resources available at UNG, including the NC Translational and Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr. Juliana's involvement in these programs, as well as the School of Medicine MD/PhD program and the UNG Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees. The proposed CAMMM study (Comparative Analysis of Methods for Malaria Movement) will aid the malaria elimination agenda by providing a better understanding of how parasites move in space in different transmission settings, Understanding the spatial dynamics of parasite migration and transmission can help define hot spots for intervention, define importation, and inform models to predict the spread of resistance. However, to realize this goal, a better understanding of what genomic methods work in different locations and transmission intensities is needed. Combining advances in genotyping with training in spatial and transmission modeling though didactic and a mentored experience at Imperial College London will provide Dr. Juliano and his mentees the ability to strengthen their research and translate their genomic findings into actionable information. The proposed K24 will permit Dr. Juliano to develop a research platform that is a natural extension of his previous work, will result in a significant methodological advance for the study of malaria transmission, will enhance his mentoring skills to ensure an equitable environment for all trainees, and will establish new research opportunities to foster the career development and mentoring of trainees and young faculty members in POR.

项目摘要 乔纳森·朱利亚诺（Jonathan Juliano）博士是疟疾研究的国际认可领导者，也是使用下一代测序技术用于应用基因组学项目的先驱。他是北卡罗来纳大学教堂山分校传染病科教授，在那里他帮助建立了一个主要的转化疟疾研究中心。 He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control, He is recognized as an outstanding mentor, having received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNG for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD涉及POR的学生提议续签其K24奖的学生将使Juliano博士能够通过获得有效领导力的学习策略，并在其K24中发展的指导技能来发展新的研究技能，从而增强其研究专业知识和指导。特别是，他将新专注于专门针对通过正式和非正式指导来指导不同学员的技能。为了促进学员的职业发展，朱利亚诺博士将利用UNG提供的广泛培训资源，包括NC转化和临床科学研究所，吉林斯全球公共卫生学院和医学院。朱莉安娜（Juliana）博士参与了这些计划，医学院医学院/博士学位课程和UNG传染病奖学金计划，可确保他将在招募和导师学员方面处于良好状态。拟议的CAMMM研究（对疟疾运动方法的比较分析）将通过更好地理解寄生虫在不同传播环境中如何在太空中移动，了解寄生虫迁移和传播的空间动态可以帮助定义热点以进行干预，定义进口，并告知模型以预测抵抗力的传播。但是，要实现这一目标，需要更好地理解哪些基因组方法在不同位置和传播强度的工作。结合基因分型的进步与虽然是教学的空间和传输建模培训，并在伦敦帝国学院的指导经验将为朱利安诺博士和他的受训者提供加强研究并将其基因组发现转化为可行的信息的能力。拟议的K24将允许Juliano博士开发一个研究平台，这是他先前工作的自然延伸，将为疟疾传播研究带来重大的方法论进步，将提高他的指导能力，以确保所有受训者的公平环境，并将为所有研究人员建立新的研究机会，以促进POR中的教练和年轻教师的职业发展和指导。