Biostatistics

生物统计学

基本信息

批准号：
10319510
负责人：
MITHAT GONEN
金额：
$ 97.82万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-01-20 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10319510
关键词：
Adopted Area Biological Assay Biometry Biostatistics Core Cancer Center Cancer Center Support Grant Charge Clinical Trials Clinical Trials Design Collaborations Consult Data Development Diagnostic Procedure Educational Activities Ensure Epidemiologic Methods Evidence Based Medicine Faculty Funding Genetic Genomics Grant Human Resources Image Individual Institution Interdisciplinary Study Master&apos s Degree Medicine Mentors Methodology Methods Mission Observational Study Pilot Projects Plants Population Genetics Protocols documentation Psychometrics Publications Recovery Research Research Design Research Personnel Research Project Grants Research Support Seeds Services Statistical Data Interpretation Survival Analysis System Techniques Time Training United States National Institutes of Health Work anticancer research cost design early phase clinical trial experience genomic data improved member programs recruit

项目摘要

ABSTRACT The Biostatistics Core provides long-term collaborative support to established programs of research at the Cancer Center, and short-term consulting services. The work of the Core enhances the scientific objectives of the Center’s research programs by providing expertise on study design and statistical analysis. The field of biostatistics is devoted to developing an understanding of the appropriate ways to derive scientific inferences from quantitative data, and to developing methods for achieving this aim. The staff is highly trained in this field and were all recruited after extensive national searches. The Core consists of 19 doctoral-level faculty biostatisticians, assisted by 16 masters-level biostatisticians, 1 bachelor-level biostatistician, and a team of programming staff and administrative staff. The doctoral-level biostatisticians in the Core have broad, collective experience in all of the specialized areas of statistical techniques that are pertinent to contemporary cancer research, including clinical trials methodology, survival analysis, epidemiologic methods, analysis of genomics data, statistical genetics, methods for diagnostic medicine, evidence-based medicine and psychometric methods. Cost recovery is achieved primarily through involvement of the Core members and staff as funded co-investigators on NIH grants. By providing a valid framework for the design, conduct and analysis of scientific studies, the Core contributes to scientific quality and promotes interdisciplinary research. The broad range of services and collaborative work provided by the Biostatistics Core has supported the research of 482 investigators in the past year. During the past grant period the work of the Core has contributed to 2,539 publications of researchers from 9 research programs. For example, the Biostatistics Core developed a method called FACETS to infer copy number alterations from the institution’s IMPACT sequencing assay. FACETS has quickly become part of the standard toolkit of genomic analysis at MSK.

抽象的生物统计学核心为已建立的研究项目提供长期合作支持癌症中心和短期咨询服务的核心工作增强了科学目标。该中心通过提供研究设计和统计分析方面的专业知识来开展研究项目。生物统计学致力于发展对得出科学推论的适当方法的理解从定量数据到开发实现这一目标的方法，工作人员在该领域接受过严格的培训。核心人员由 19 名博士级教师组成。生物统计学家，由16名硕士级生物统计学家、1名学士级生物统计学家以及一支核心人员中的博士级生物统计学家具有广泛的集体性。与当代癌症相关的统计技术的所有专业领域的经验研究，包括临床试验方法、生存分析、流行病学方法、基因组学分析数据、统计遗传学、诊断医学方法、循证医学和心理测量学成本回收主要通过核心成员和工作人员的参与来实现。 NIH 资助的联合研究人员为科学的设计、实施和分析提供有效的框架。研究，核心有助于提高科学质量并促进广泛的跨学科研究。生物统计核心提供的服务和协作工作支持了以下研究：第 482 章在过去的一年里，核心的工作为 2,539 人做出了贡献。例如，生物统计学核心开发了 9 个研究项目的研究人员的出版物。一种名为 FACETS 的方法可根据该机构的 IMPACT 测序分析推断拷贝数变化。 FACETS 已迅速成为 MSK 斯隆基因组分析标准工具包的一部分。