Biostatistics

生物统计学

• 批准号: 10084831
• 负责人: MITHAT GONEN
• 金额: $ 97.82万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-20 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10084831
• 关键词: Adopted; Area; Biological Assay; Biometry; Biostatistics Core; Cancer Center; Cancer Center Support Grant; Charge; Clinical Trials; Clinical Trials Design; Collaborations; Consult; Data; Development; Diagnostic Procedure; Educational Activities; Ensure; Epidemiologic Methods; Evidence Based Medicine; Faculty; Funding; Genetic; Genomics; Grant; Human Resources; Image; Individual; Institution; Interdisciplinary Study; Master' s Degree; Medicine; Mentors; Methodology; Methods; Mission; Observational Study; Pilot Projects; Plants; Population Genetics; Protocols documentation; Psychometrics; Publications; Recovery; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Seeds; Services; Statistical Data Interpretation; Survival Analysis; System; Techniques; Time; Training; United States National Institutes of Health; Work; anticancer research; cost; design; early phase clinical trial; experience; genomic data; improved; member; programs; recruit

ABSTRACT The Biostatistics Core provides long-term collaborative support to established programs of research at the Cancer Center, and short-term consulting services. The work of the Core enhances the scientific objectives of the Center’s research programs by providing expertise on study design and statistical analysis. The field of biostatistics is devoted to developing an understanding of the appropriate ways to derive scientific inferences from quantitative data, and to developing methods for achieving this aim. The staff is highly trained in this field and were all recruited after extensive national searches. The Core consists of 19 doctoral-level faculty biostatisticians, assisted by 16 masters-level biostatisticians, 1 bachelor-level biostatistician, and a team of programming staff and administrative staff. The doctoral-level biostatisticians in the Core have broad, collective experience in all of the specialized areas of statistical techniques that are pertinent to contemporary cancer research, including clinical trials methodology, survival analysis, epidemiologic methods, analysis of genomics data, statistical genetics, methods for diagnostic medicine, evidence-based medicine and psychometric methods. Cost recovery is achieved primarily through involvement of the Core members and staff as funded co-investigators on NIH grants. By providing a valid framework for the design, conduct and analysis of scientific studies, the Core contributes to scientific quality and promotes interdisciplinary research. The broad range of services and collaborative work provided by the Biostatistics Core has supported the research of 482 investigators in the past year. During the past grant period the work of the Core has contributed to 2,539 publications of researchers from 9 research programs. For example, the Biostatistics Core developed a method called FACETS to infer copy number alterations from the institution’s IMPACT sequencing assay. FACETS has quickly become part of the standard toolkit of genomic analysis at MSK.

抽象的 生物统计学核心为建立的研究计划提供了长期协作支持 癌症中心和短期咨询服务。核心的工作增强了科学目标 该中心的研究计划通过提供研究设计和统计分析的专业知识。领域 生物统计学致力于发展对获得科学推论的适当方法的理解 从定量数据到开发实现此目标的方法。员工在这个领域接受了高度训练 并在全国范围内进行了广泛的招募。核心由19个博士学位教师组成 生物统计学家，由16位大师级生物统计学家，1位单身汉的生物统计学家和一支团队的协助 编程人员和行政人员。核心的博士级生物统计学家拥有广泛的集体 在与当代癌症有关的统计技术的所有专业领域的经验 研究，包括临床试验方法，生存分析，流行病学方法，基因组分析 数据，统计遗传学，诊断医学的方法，循证医学和心理测量学 方法。成本恢复主要是通过资助的核心成员和员工的参与来实现的 NIH赠款的共同投资者。通过为科学的设计，进行和分析提供有效的框架 研究，核心有助于科学质量并促进跨学科研究。广泛的范围 生物统计学核心提供的服务和协作工作支持了482的研究 过去一年的调查人员。在过去的赠款期间，核心的工作贡献了2,539 来自9个研究计划的研究人员的出版物。例如，生物统计学核心开发了 从机构的影响测序分析中推断出复制号更改的方法。 方面已迅速成为MSK基因组分析标准工具包的一部分。