SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults

SHARE 计划：转化行为科学创新，以改善新兴成年人对艾滋病毒和酒精的自我管理

• 批准号: 10304691
• 负责人: Karen MacDonell
• 金额: $ 142.89万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304691
• 关键词: AIDS/HIV problem; Address; Adult; Age; Alcohol consumption; Alcohols; Basic Behavioral Science; Behavior; Behavior Therapy; Behavioral; Behavioral Sciences; Behavioral trial; Big Data; Chronic Disease; Communities; Competence; Data Science Core; Decision Making; Development; Disease Progression; Elderly; Electronic Health Record; Ensure; Epidemic; Face; Feedback; Florida; Foundations; Goals; HIV; HIV Infections; HIV diagnosis; Health; Individual; Intervention; Life; Life Style; Link; Literature; Mental Health; Methods; Modeling; Monitor; Motivation; Neurocognition; Outcome; Pharmaceutical Preparations; Phase; Physical activity; Problem Solving; Program Research Project Grants; Psychological reinforcement; Public Health; Research; Research Project Grants; Risk; Risk Behaviors; Risk-Taking; Role; Self Management; Self-control as a personality trait; Sleep; Stress; Substance abuse problem; Technology; Testing; Tobacco; Translating; Translations; United States; United States National Institutes of Health; Viral; Viral Load result; Work; Youth; age group; alcohol comorbidity; alcohol monitoring; community engagement; community partnership; comorbidity; comparative effectiveness trial; efficacious intervention; emerging adult; emerging adulthood; expectation; improved; innovation; intervention program; new technology; physical conditioning; programs; psychosocial; recruit; scale up; secondary analysis; skills; social; social stigma; substance use; symptom management; symptom treatment; therapy design; therapy development; translational pipeline; translational study; transmission process; treatment as prevention

SHARE P01 ABSTRACT The purpose of the SHARE P01 research program project is to address HIV and alcohol use around three themes; 1) Emerging adulthood (ages 18 -29); 2) Self-management of HIV and alcohol; and 3) Translational behavioral science. Emerging adulthood is a developmental stage marked by significant change in social roles, expectations as a new adult, and increased responsibilities. It is also marked by poor HIV self- management and increased alcohol use. Emerging adults with HIV (hereafter called young people living with HIV; YPLWH) may face even more challenges given intersectional stigma. This age group continues to have very high rates of new HIV infections. Interventions designed specifically for the unique developmental challenges of emerging adults are needed, yet emerging adults are often included with older adults in intervention programs. The concept of self-management emerged concurrently within both the substance abuse and chronic illness literatures, and fits well with the developmental challenges of emerging adulthood. Self-management, a framework we have utilized in our work with YPLWH, refers to the ability to manage symptoms, treatments, lifestyle changes, and consequences of health conditions. Current research now identifies individual-level self-management skills such as self-control, decision-making, self-reinforcement, and problem solving as that protect against substance use and improve other health outcomes and can be embedded in the Information-Motivation-Behavioral Skills model. Although we have conducted multiple studies with YPLWH, only one intervention to date (Healthy Choices conducted by our team) improved both alcohol use and viral suppression in YPLWH in large trials. The goal of the SHARE P01 is to utilize advances in translational behavioral science to optimize behavioral interventions and define new developmentally- and culturally-appropriate intervention targets to improve self-management of alcohol and HIV in YPLWH. We will focus our efforts in Florida, a state hardest hit by the HIV epidemic but with a particularly strong academic- community partnership to support translation. We have assembled research teams to conduct self- management studies across the translational spectrum to address self-management and improve alcohol use and viral suppression (and thereby reduce transmission) in diverse YPLWH in Florida. The P01 will consist of three research projects (DEFINE, ENGAGE, and SUSTAIN), representing different stages on the translational spectrum and targeting different core competencies, supported by two cores (Community Engagement Core and Data Science Core). If successful, the SHARE P01 has the potential to greatly advance programs promoting self-management of HIV and alcohol use among a particularly vulnerable, but under-researched group, emerging adults living with HIV. SHARE also has a high potential for scale-up and implementation beyond Florida and across the United States.

共享P01摘要 Share P01研究计划项目的目的是解决三个艾滋病毒和酒精的使用 主题； 1）成年（18岁时）； 2）艾滋病毒和酒精的自我管理； 3）翻译 行为科学。新兴的成年是一个发展阶段，其标志着社会的重大变化 角色，新成年人的期望以及责任增加。它也以较差的艾滋病毒自我为特征 管理和增加酒精。新兴的艾滋病毒成年人（以下称为年轻人 艾滋病病毒;鉴于交叉污名，yplwh）可能面临更多的挑战。这个年龄段继续 新的HIV感染率非常高。专门为独特发展设计的干预措施 需要新兴成年人的挑战，但新兴成年人通常与老年人一起包含 干预计划。自我管理的概念在两种物质中同时出现 虐待和慢性疾病文献，非常适合新兴成年的发展挑战。 自我管理，这是我们与YPLWH合作中使用的框架，是指管理能力 症状，治疗，生活方式的改变和健康状况的后果。现在的研究 确定个人级别的自我管理能力，例如自我控制，决策，自我强化和 解决问题是因为可以防止药物使用并改善其他健康结果，并且可以是 嵌入在信息动机行为技能模型中。尽管我们进行了多个 对YPLWH的研究，迄今为止只有一项干预措施（我们的团队进行的健康选择）都改善了 在大型试验中，YPLWH中的酒精使用和病毒抑制。共享P01的目标是利用进步 在翻译行为科学中以优化行为干预措施并在发展上定义新的发展和 具有文化适当的干预措施，以改善YPLWH中酒精和艾滋病毒的自我管理。我们将 将我们的努力集中在佛罗里达州，这是艾滋病毒流行病的最严重打击，但学术尤其强大 - 社区合作伙伴关系以支持翻译。我们已经组装了研究团队来进行自我 跨翻译光谱的管理研究，以解决自我管理和改善酒精使用 以及佛罗里达州各种YPLWH的病毒抑制（从而减少传播）。 P01将包括 三个研究项目（定义，参与和维持），代表翻译的不同阶段 频谱和针对不同的核心能力，并由两个核心（社区参与核心）支持 和数据科学核心）。如果成功，Share P01有可能大力推进计划 促进特别脆弱但研究不足的艾滋病毒和饮酒的自我管理 小组，新兴的成年人患有艾滋病毒。共享也具有扩大和实施的高潜力 在佛罗里达州和整个美国之外。