Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data

组件 A：北卡罗来纳州 - 使用 SEED 和 SEED 后续数据推进发展研究

• 批准号: 10300120
• 负责人: Julie L Daniels
• 金额: $ 58.13万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10300120
• 关键词: Component; North; Carolina; Advancing; Developmental

Project Summary - SEED Follow-up Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The NC SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in North Carolina and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

项目摘要 - 种子随访 自闭症谱系障碍（ASD）是一种神经发育障碍，约有1.5％ 美国的孩子。在社交交流或受限制中具有ASD经验辩护的个人 兴趣和重复行为；但是，严重性和模式差异很大，并传达了终身障碍 一些。目前尚不清楚ASD的介绍如何从幼儿期变为青少年或成年。 ASD的原因也未知，尽管大量证据支持这两个基因的贡献 和环境因素。知识中的这些差距之所以存在，是因为迄今为止的美国研究缺乏 样本量，数据收集深度或适当的生活课程时间，以解决这些问题。研究 探索早期发展（种子）现在能够解决这些先前的限制。种子是一个大案例 - 2-5岁儿童的对照研究及其家人在三个阶段的八个州进行了实施。 种子收集了有关儿童核心ASD症状，认知状况以及共同存在的详细数据 幼儿时期发生的情况，以及与孕产妇健康有关的广泛危险因素 围产期环境以及基因组学。种子样本包括2044名ASD儿童，1950年儿童 患有非ASD发育障碍（DD）和2285名人口控制儿童（POP），使这 美国ASD最大的病因研究。近期辅助研究 - 种子青少年飞行员和种子共同研究 研究 - 很快将添加有关青少年健康和大流行的后果的数据 一些种子参与者。这里提出的工作，种子后续研究（种子FU）将最大化 通过特征ASD表型的分析来影响额外的种子数据并评估潜力 遗传和可修改风险因素之间的相互作用。种子FU还将促进新的数据收集 童年，青少年和成年早期，以表征整个ASD表型的变化 发展阶段以及早期生活课程中相关的健康，教育和服务需求。 这些数据将进一步实现对早期生命因素之间关联的前瞻性分析 童年到成年初期。研究与生活课程表型有关的危险因素 亚组还可以帮助阐明先前在ASD病例对照研究中掩盖的病因。 NC种子 团队结合种子网络的协作基础架构和广泛的现有数据 资源，将确保在北卡罗来纳州成功实施种子FU研究，并为 整个网络的成功。种子为我们的理解做出重大贡献而有力 复杂的自闭症表型和识别与人群中ASD风险相关的因素。这 种子FU获得的知识将极大地提高我们的能力，以防止不利的发展结果和 支持ASD及其家人的个人，以确保成年初期的最佳福祉。