Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data

组件 A：北卡罗来纳州 - 使用 SEED 和 SEED 后续数据推进发展研究

• 批准号: 10407927
• 负责人: Julie L Daniels
• 金额: $ 58.89万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407927
• 关键词: Component; North; Carolina; Advancing; Developmental

Project Summary - SEED Follow-up Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impacts approximately 1.5% of children in the United States. Individuals with ASD experience deficits in social communication or restricted interests and repetitive behavior; but the severity and patterns vary greatly and convey lifelong impairment for some. It is unclear how the presentation of ASD changes from early childhood into adolescence or adulthood. The causes of ASD are also unknown, though substantial evidence supports the contribution of both genes and environmental factors. These gaps in knowledge exist because US studies to date have lacked the sample size, depth of data collection, or appropriate life course timing to address these questions. The Study to Explore Early Development (SEED) is now able to address these prior limitations. SEED is a large case- control study of children ages 2-5 years and their families, implemented across eight states over three phases. SEED collected detailed data on children’s core ASD symptoms, cognitive status, and presence of co- occurring conditions in early childhood, along with extensive risk factors related to maternal health and the perinatal environment as well as genomics. The SEED sample includes 2044 children with ASD, 1950 children with non-ASD developmental disabilities (DD), and 2285 population control children (POP), making this the largest etiologic study of ASD in the US. Recent ancillary studies - the SEED Teen Pilot and SEED COVID studies -- will soon add data on adolescent health and the consequences of the pandemic, respectively, for some SEED participants. The work proposed here, SEED Follow-up Studies (SEED FU), will maximize the impact of extant SEED data through analyses that characterize ASD phenotypes and assess the potential interplay between genetic and modifiable risk factors. SEED FU will also facilitate new data collection in middle childhood, adolescence and early adulthood to characterize changes in ASD phenotype across developmental stages, and the associated health, educational, and service needs across the early life course. These data will further enable prospective analyses of associations between early life factors and later childhood through early adulthood outcomes. Studying risk factors in relation to life course phenotypic subgroups may also help elucidate etiologies previously masked in ASD case-control studies. The NC SEED Team in combination with the SEED Network’s collaborative infrastructure and extensive extant data resources, will ensure the successful implementation of the SEED FU Study in North Carolina and contribute to success across the network. SEED is well-powered for making significant contributions to our understanding of the complex autism phenotype and identifying factors associated with ASD risk in the population. The knowledge gained by SEED FU will greatly advance our ability prevent adverse developmental outcomes and to support individuals with ASD and their families to ensure optimal wellbeing through early adulthood.

项目摘要 - SEED 后续行动 自闭症谱系障碍 (ASD) 是一种神经发育障碍，影响大约 1.5% 的人 美国患有自闭症谱系障碍 (ASD) 的儿童在社交沟通方面存在缺陷或受到限制。 兴趣和重复行为；但严重程度和模式差异很大，并会造成终生损害。 目前还不清楚自闭症谱系障碍的表现从幼儿期到青春期或成年期是如何变化的。 自闭症谱系障碍的病因尚不清楚，但有大量证据支持这两个基因的贡献 这些知识差距的存在是因为美国迄今为止的研究缺乏这些知识。 解决这些问题的样本量、数据收集深度或适当的生命历程时间。 探索早期开发 (SEED) 现在能够解决这些先前的限制，这是一个大案例。 针对 2-5 岁儿童及其家庭的对照研究，在八个州分三个阶段实施。 SEED 收集了有关儿童核心 ASD 症状、认知状态和共存症状的详细数据 儿童早期发生的疾病，以及与孕产妇健康和婴儿相关的广泛危险因素 围产期环境以及基因组学。SEED 样本包括 2044 名患有 ASD 的儿童、1950 名儿童。 患有非 ASD 发育障碍 (DD) 和 2285 名人口控制儿童 (POP)，使其成为 美国最大的 ASD 病因学研究 - SEED Teen Pilot 和 SEED COVID。 研究——很快将分别添加有关青少年健康和大流行的后果的数据 一些 SEED 参与者在此提出的工作，即 SEED 后续研究 (SEED FU)，将最大限度地提高 通过分析描述 ASD 表型并评估潜力，了解现有 SEED 数据的影响 遗传和可改变的风险因素之间的相互作用也将促进新的数据收集。 童年中期、青春期和成年早期来表征跨性别自闭症谱系障碍 (ASD) 表型的变化 发展阶段，以及整个生命早期相关的健康、教育和服务需求。 这些数据将进一步对早期生活因素与以后生活因素之间的关联进行前瞻性分析。 研究与生命历程表型相关的危险因素。 亚组还可能有助于阐明先前在 ASD 病例对照研究中被掩盖的病因。 团队与 SEED Network 的协作基础设施和广泛的现有数据相结合 资源，将确保 SEED FU 研究在北卡罗来纳州的成功实施，并有助于 SEED 在网络上的成功足以为我们的理解做出重大贡献。 复杂的自闭症表型并确定与人群中自闭症风险相关的因素。 通过 SEED FU 获得的知识将极大地提高我们预防不良发育结果的能力， 支持自闭症谱系障碍患者及其家人，确保他们在成年早期保持最佳的福祉。