University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)

马里兰大学克劳德·D·佩珀美国老年人独立中心 (OAIC)

• 批准号: 10293639
• 负责人: Leslie I. Katzel
• 金额: $ 100.32万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10293639
• 关键词: Academy; Acute; Aerobic; Affect; Aging; American; Animal Model; Area; Biostatistics Core; Capsicum; Caring; Cessation of life; Chronic Disease; Clinic; Clinical; Clinical Services; Collaborations; Communities; Degenerative polyarthritis; Development; Disabled Persons; Discipline; Disease Pathway; Elderly; Engineering; Enrollment; Environment; Evaluation; Event; Exercise; Faculty; Fatigue; Funding; Future; Geriatrics; Health Promotion; Heart failure; Hip Fractures; Home; Homes for the Aged; Impaired cognition; Impairment; Informatics; Institutionalization; Intervention; Knowledge; Laboratories; Lead; Leadership; Life Expectancy; Maintenance; Malignant Neoplasms; Maryland; Medical; Mentors; Mission; Myocardial Infarction; Neuronal Plasticity; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Study; Parkinson Disease; Physiological; Physiology; Prevention; Process; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Risk; Robotics; SARS-CoV-2 infection; Scientist; Services; Stroke; Technology; Testing; Training; Translating; Translational Research; Translations; Treatment Efficacy; Underrepresented Minority; Universities; Vascular Diseases; Work; aged; base; bench to bedside; body system; career; clinical center; clinically relevant; community setting; design; disability; disabling disease; education research; efficacy testing; exercise rehabilitation; frailty; functional disability; functional independence; functional restoration; improved; improved functioning; industry partner; innovation; multimodality; new technology; next generation; novel; novel strategies; operation; pre-clinical; prevent; programs; public health priorities; rehabilitation research; rehabilitation science; rehabilitation strategy; rehabilitation technology; research and development; restoration; sarcopenia

7. Project Summary: Overall The theme of the UM-OAIC is enablement defined as the restoration of function in those with impairments and the prevention or delay of further progression in those who are already disabled. The overarching mission of the UM-OAIC is to develop, implement, and evaluate rehabilitative strategies that are designed to improve and restore mobility and functional independence in older persons with disabling conditions. This will be accomplished by 1) advancing our understanding of the mechanisms by which exercise and activity-based and multi-modal rehabilitation interventions directed at specific impairments affect multiple body systems; 2) developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases; and 3) training the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. The functional impairments and disabilities that occur in older people emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. This pathway of how disease leads to disability, i.e., disablement, has been discussed extensively. The UM-OAIC’s mission builds knowledge of disablement and focuses on the restoration of function in those with impairments and to prevent or delay further progression in those already disabled, i.e. enablement. The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the functional impairments associated with acute disabling events (e.g., stroke, hip fracture) and prevalent chronic diseases (e.g., heart failure, cancer) in older people. 2) Design novel, exercise and activity-based and rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them. 3) Translate interventions developed in UM-OAIC clinical laboratories and elsewhere for implementation and rigorous evaluation in home and community settings. 4) Support pilot and exploratory studies, UM-OAIC Scholar research, development projects, and externally funded projects that are consistent with the UM-OAIC theme. 5) Support the development of junior faculty and Scholars from multiple disciplines as they pursue careers as independent, academic scientists and leaders with expertise in the study of older persons with disabling diseases through mentor-based, didactic and experiential training in bench-to-bedside-to-community translational research.

7。项目摘要：总体 UM-OAIC的主题被启用定义为在有障碍的人中的恢复功能的恢复 已经残疾的人的预防或延迟进一步进展。总体使命的任务 UM-OAIC是制定，实施和评估旨在改进和的康复策略 恢复具有残疾条件的老年人的流动性和功能独立性。这将是 通过1）促进我们对基于运动和基于活动的机制的理解以及 针对特定损伤的多模式康复干预措施会影响多个身体系统； 2） 急性残疾事件后，开发和测试干预措施以恢复功能并最大程度地减少残疾 并防止与严重慢性疾病有关的下降； 3）培训下一代调查人员 谁将进一步了解衰老过程并制定干预措施，以帮助促进健康和 患有医疗状况的老年人的独立性。 老年人中发生的功能障碍和疾病源于急性事件，例如 中风，心脏病发作和髋部骨折，或反映慢性疾病的进展。这条如何 疾病导致残疾，即残疾，已广泛讨论。 UM-OAIC的任务建造 对残疾的了解，并专注于恢复受损的人的功能，并防止 或延迟已经禁用的人的进一步进展，即启用。 UM-OAIC的目的是：1）进行研究的研究，以检查该机制 与急性禁用事件有关（例如，中风，髋部骨折）和普遍的慢性功能障碍 老年人的疾病（例如心力衰竭，癌症）。 2）设计小说，锻炼和基于活动和活动 康复干预措施产生临床相关结果并研究基础机制 他们。 3）翻译在UM-OAIC临床实验室和其他地方实施的干预措施 以及在家庭和社区环境中进行严格的评估。 4）支持飞行员和探索性研究，UM-OAIC 学者研究，开发项目以及与UM-OAIC一致的外部资助项目 主题。 5）在购买时支持从多个学科的初级教师和学者的发展 作为独立的学术科学家和领导者的职业，在研究老年人方面具有专业知识 通过基于心理的，教学和经验丰富的培训在基准对床到社区的培训中禁用疾病 翻译研究。