GENETICS, EXERCISE AND BLOOD PRESSURE IN HYPERTENSIVES

高血压患者的遗传、运动和血压

• 批准号: 2858455
• 负责人: Leslie I. Katzel
• 金额: $ 11.68万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2858455
• 关键词: aerobic exercise; aging; blood lipoprotein metabolism; blood pressure; cardiovascular function; clinical research; clinical trials; echocardiography; familial hypertension; gene environment interaction; genetic polymorphism; genetic susceptibility; genotype; glucose clamp technique; glucose metabolism; heart rate; human old age (65+); human subject; human therapy evaluation; hypertension; nuclear magnetic resonance spectroscopy; peptidyl dipeptidase A; psychological stressor; psychophysiology; ultrasound blood flow measurement; weight loss

A Ph.D. biophysics from Johns Hopkins University (JHU), a MD from the University of Maryland (UMSOM), with postdoctoral clinical and research training in gerontology at JHU and NIA/GRC, and a NIA KO8 with postdoctoral clinical and research training in gerontology prepared the candidate for an academic career in gerontology. The candidate, an Associate Professor of Medicine at the UMSOM has 10 years of experience performing patient oriented research into the effects of weight loss and aerobic exercise training (AEX) on lipoprotein and glucose metabolism, and cardiovascular function in older men and women. The candidate directs clinical research at the BVAMC GRECC, is PI on a VA Merit Review grant, and co-PI on the UMSOM Pepper Center. The candidate has mentored 17 trainees in patient oriented research. Receipt of this K24 award will provide the candidate additional protected time for research and mentoring of gerontology MD fellows, postdoctoral Ph.D. fellows, and other trainees in patient oriented clinical investigations. The candidate's long term goal is to establish a nationally recognized center of excellence for research into gene-environment interactions and their influence on the prevention and treatment of cardiovascular diseases (CVD) in the elderly. Research: Prior studies demonstrate that the angiotensin converting enzyme (ACE) DD gene variant present in 25-30 percent of the population increases the risk for hypertension, stroke and cardiovascular disease. The study hypothesis is that in older hypertensive individuals, the ACE DD polymorphism will blunt the beneficial effects of AEX on BP, lipoprotein and glucose metabolism, and cardiovascular function compared to individuals with the ACE ID and II genotypes. This hypothesis will be tested in a clinical trial that will compare the effects of 6 months of AEX on BP, the BP response to mental stress (cardiovascular reactivity), metabolic function (lipoproteins, glucose clamp) and endothelial function in older hypertensives with the ACE DD versus ACE ID and II genotypes. Trainees will participate in all aspects of this research and learn how to design and implement clinical investigations that enhance our knowledge of gene-environmental interactions in moderating the effectiveness of AEX in lowering BP, and in improving metabolic and cardiovascular function in older hypertensive patients. This research may lead to targeted lifestyle and pharmacologic therapies based on genotype to treat hypertension and CVD in older patients.

博士约翰·霍普金斯大学（JHU）的生物物理学，马里兰州大学（UMSOM）的A MD，JHU和NIA/GRC的老年医学博士后临床和研究培训，以及NIA KO8，并接受了NIA KO8，并接受了博士后临床和研究培训的培训，从而为候选人提供了候选者的学术职业。 候选人是UMSOM的医学副教授，具有10年的经验，以患者为导向的研究对体重减轻和有氧运动训练的影响（AEX）对脂蛋白和葡萄糖代谢的影响以及老年男性和女性的心血管功能。 该候选人指导BVAMC GRECC的临床研究，是VA功绩审查资助的PI，在UMSOM Pepper中心的Co-Pi。候选人指导了17名面向患者的研究人员。 该K24奖的收到将为候选人提供额外的受保护时间，以研究和指导老年医学博士学位研究员，博士后博士学位。研究员和其他学员进行了以患者为导向的临床研究。 候选人的长期目标是建立一个全国认可的卓越中心，以研究基因环境相互作用及其对老年人心血管疾病（CVD）的影响和治疗的影响。 研究：先前的研究表明，25-30％人群中的血管紧张素转化酶（ACE）DD基因变异增加了高血压，中风和心血管疾病的风险。 研究假设是，与具有ACE ID和II基因型的个体相比，在老年高血压个体中，ACE DD多态性将钝化AEX对BP，脂蛋白和葡萄糖代谢以及心血管功能的有益作用。 该假设将在一项临床试验中进行测试，该试验将比较6个月AEX对BP的影响，BP对精神应激的反应（心血管反应性），代谢功能（脂蛋白，葡萄糖夹）和内皮性高血压与ACE DDDDDDDDDDDDDDDDDDDD和II基因型在较旧的高血压中的作用。学员将参与这项研究的各个方面，并学习如何设计和实施临床研究，从而增强我们对基因环境相互作用的了解，以调节AEX降低BP的有效性，并改善老年高血压患者的代谢和心血管功能。 这项研究可能导致基于基因型的靶向生活方式和药理疗法，以治疗老年患者的高血压和CVD。