High Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging
用于全脑功能成像的高频可穿戴透明电致伸缩行列阵列
基本信息
- 批准号:10293940
- 负责人:
- 金额:$ 16.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-Dimensional3D ultrasoundAcousticsAddressAlberta provinceAnimalsAttentionBRAIN initiativeBackBloodBlood flowBrainBrain imagingCalciumCellsCollaborationsDevelopmentDevicesDrug Delivery SystemsElectrodesElementsFrequenciesFunctional ImagingFunctional Magnetic Resonance ImagingFutureGlassHeadImageImaging PhantomsImaging technologyIndividualLasersLeadLightLightingMeasuresMethodsMicroscopyModelingMolecularNeuronsNeurosciencesNeurosciences ResearchNoiseOpticsPhysiologic pulsePublic HealthRattusReporterResearchResearch MethodologyResearch PersonnelResolutionRodentSchemeSignal TransductionSystemTechnologyTestingTextTimeTransducersUltrasonic TransducerUltrasonographyUnited States National Institutes of HealthUniversitiesVariantVibrissaeWorkanimal imagingawakeblood-brain barrier disruptioncellular imagingcerebral blood volumedesignexperimental studyhuman subjectimaging modalityimplantable deviceindium tin oxideneonateneuroimagingneurosurgerynext generationnoveloptical imagingoptogeneticsphotoacoustic imagingprogramspublic health relevancetemporal measurement
项目摘要
Project Summary/Abstract Section
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.
We propose the development of a novel bias-switchable row-column 2D ultrasound transducer array technology for 3D ultrasound and photoacoustic imaging of whole-brain functional activity with potential for a wearable format for awake and moving animals. These can be developed into high- frequency arrays and even transparent variants that should allow optical and ultrasonic imaging down to resolutions of 30 microns, approaching single-neuron scales. Unlike previous 2D array technologies that require wires connecting to each transducer element, our approach requires only row- and column addressing, yet permits readout from every element of the array using novel electrostrictive bias switching approaches. The technology promises first-of-it’s kind volumetric functional brain imaging of blood-flow changes, blood oxygenation changes, and even neuron activity over the whole brains of awake and moving rodents. The array offers significant potential for next-generation neuroscience experiments involving both optical and acoustic methods, including future work combining functional ultrasound and photoacoustic imaging with optogenetics, optical microscopy of genetically-encoded reporters of neuron activity, ultrasound neuro-stimulation, ultrasound blood-brain barrier disruption for drug delivery, and more. The arrays have considerable translational potential for future human subject imaging in neurosurgeries, neonates, and with potential for implantable devices for longitudinal functional brain imaging. Our research methods include careful design and fabrication of these high-frequency arrays with special attention to transparent variants. We also develop novel imaging schemes and implement these schemes on programmable ultrasound systems. Testing will include array characterization, imaging phantoms, imaging cells expressing near-infrared (NIR) genetically-encoded reporters of neuron Calcium activity. If successful, future work will go on to implement animal imaging experiments aiming to visualize functional brain imaging due to whisker stimulation in both anesthetized and awake- moving animals.
项目摘要/摘要部分
在此处输入文本,这是您应用程序的新摘要信息。本节必须不超过30行文本。
我们提出了一种新型的偏置连接行柱2D超声传感器阵列技术的开发,用于3D超声和全脑功能活动的光声成像,具有可穿戴格式的清醒和移动动物的可能性。这些可以发展为高频阵列甚至透明的变体,这些变体应允许光学和超声成像降低到30微米的分辨率,接近单神经元尺度。与以前的2D数组技术需要连接到每个换能器元素的电线,我们的方法仅需要行和列的地址,但允许使用新型的电折线偏置开关方法从数组的每个元素进行读数。该技术承诺,首先是血液流量变化,血液氧合变化的型体积功能性脑成像,甚至在整个清醒和移动啮齿动物的大脑上都具有神经元的活性。该阵列为涉及光学和声学方法的下一代神经科学实验提供了巨大的潜力,包括将功能性超声和光声成像与光遗传学与光遗传学的未来工作,神经元活性的光学显微镜检查,超声神经仿真的遗传编码记者的光学显微镜检查,超声神经障碍,超声血脑屏障,药物脱离药物,以供药物交付。这些阵列被认为是在神经外神灵,新生儿中的未来人类主体成像的翻译潜力,并具有用于纵向功能性脑成像的植入式设备的潜力。我们的研究方法包括仔细设计和制造这些高频阵列,并特别注意透明变体。我们还开发了新颖的成像方案,并在可编程超声系统上实施这些方案。测试将包括阵列表征,成像幻象,成像细胞表达神经元钙活性的近红外(NIR)遗传编码的记者。如果成功,未来的工作将继续实施动物成像实验,旨在可视化麻醉和清醒动物中的晶须模拟引起的功能性脑成像。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Roger J Zemp其他文献
Roger J Zemp的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Roger J Zemp', 18)}}的其他基金
Wearable Electrostrictive Row-Column Ultrasound Arrays for Longitudinal Echocardiography
用于纵向超声心动图的可穿戴电致伸缩行列超声阵列
- 批准号:
10610780 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别:
Wearable Electrostrictive Row-Column Ultrasound Arrays for Longitudinal Echocardiography
用于纵向超声心动图的可穿戴电致伸缩行列超声阵列
- 批准号:
10354880 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别:
High Frequency Wearable and Transparent Electrostrictive Row-Column Arrays for Whole Brain Functional Imaging
用于全脑功能成像的高频可穿戴透明电致伸缩行列阵列
- 批准号:
10489845 - 财政年份:2021
- 资助金额:
$ 16.2万 - 项目类别:
相似国自然基金
基于多时序纵向3D超声图像Siamese多任务网络早期预测pMMR型局部进展期直肠癌PD-1单抗联合放化疗疗效
- 批准号:82302209
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
超声响应的3D压电纳米短纤维通过电信号调控骨髓间充质干细胞募集促骨缺损修复
- 批准号:82372572
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
基于3D超声心动图影像和因果知识图谱的双心室功能综合定量分析方法研究
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
基于3D超声心动图影像和因果知识图谱的双心室功能综合定量分析方法研究
- 批准号:62202092
- 批准年份:2022
- 资助金额:30.00 万元
- 项目类别:青年科学基金项目
面向3D芯片封装的双向复合超声键合机理及其换能系统设计与控制
- 批准号:52175392
- 批准年份:2021
- 资助金额:58.00 万元
- 项目类别:面上项目
相似海外基金
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
结合辐射声学和超声成像,用于放射治疗的实时指导
- 批准号:
10582051 - 财政年份:2023
- 资助金额:
$ 16.2万 - 项目类别:
Wearable Electrostrictive Row-Column Ultrasound Arrays for Longitudinal Echocardiography
用于纵向超声心动图的可穿戴电致伸缩行列超声阵列
- 批准号:
10610780 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别:
An Ionizing Radiation Acoustics Imaging (iRAI) Approach for guided Flash Radiotherapy
用于引导闪光放射治疗的电离辐射声学成像 (iRAI) 方法
- 批准号:
10707124 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别:
A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging
一种新型换能器夹式装置,可实现易于使用且功能齐全的 3D 超声成像
- 批准号:
10708132 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别:
A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging
一种新型换能器夹式装置,可实现易于使用且功能齐全的 3D 超声成像
- 批准号:
10587466 - 财政年份:2022
- 资助金额:
$ 16.2万 - 项目类别: