The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigators

“职业模式”计划：通过为早期研究人员提供组学和数据方面的指导和培训来实现职业生涯

• 批准号: 10285137
• 负责人: Andrea Baccarelli
• 金额: $ 45.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10285137
• 关键词: Address; Age; Applications Grants; Appointment; Biological Process; Biomedical Research; Clinical Medicine; Collaborations; Communication; Data; Data Analyses; Data Science; Development; Discipline; Doctor of Philosophy; Drops; Education; Educational Curriculum; Educational Materials; Educational process of instructing; Evaluation; Face; Faculty; Fostering; Funding; Future; Generations; Genomics; Goals; Grant; Grant Review; Health; Hybrids; Individual; Institution; Investments; Knowledge; Leadership; Mentors; Methods; National Institute of General Medical Sciences; Pathway interactions; Persons; Positioning Attribute; Postdoctoral Fellow; Qualitative Evaluations; Quantitative Evaluations; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Route; Science; Scientist; Secure; Social Sciences; Structure; Technology; Time; Training; Training Programs; Travel; United States; United States National Academy of Sciences; United States National Institutes of Health; Universities; Woman; Writing; career; career development; career networking; cohort; design; early-career faculty; empowered; exhaustion; experience; health equity; human disease; improved; instructor; interest; learning strategy; member; microbiome; multidimensional data; multidisciplinary; outreach; precision medicine; professor; programs; recruit; responsible research conduct; skill acquisition; skills; success; symposium; tenure track; tool; trend; virtual

PROJECT SUMMARY/ABSTRACT The National Academy of Sciences describes the barriers that scientists experience on the path from mentored to independent research as the single most critical threat to the future of biomedical sciences in the United States (US). Women and individuals from marginalized groups face steeper obstacles, particularly in technology-intensive fields such as omic sciences. Despite NIH’s separate grant reviews and paylines, the mean age at which investigators receive their first R01 has continued to climb to an all-time high of 46 years, extending a 35-year negative trend. In parallel, the likelihood of PhD graduates becoming professors has dropped significantly in the last decades, putting the future of biomedical research in the US at risk. To address these challenges, we propose the 'Career MODE' program: Careers through Mentoring and training in Omics and Data for Early-stage investigators to empower diverse cohorts of young researchers across the US—i.e., postdocs in the final years of mentored training and faculty members within two years of their first appointment—to establish independent, successful careers in omics and data sciences. Omics— ranging from genomics to the microbiome—have revolutionized biomedical sciences. As they have become part of any biomedical field, the scarcity of a workforce within each discipline with appropriate omic training has emerged as a critical challenge. We seek to develop an 11-month program to provide intensive training in omics and data science and specialized mentoring from a nationwide, diverse network of 70+ mentors. Career MODE will also feature training in professional skills, including leadership and team management, grant writing, mentoring, goal setting and strategy development, communication and teaching, scientific rigor, transparency, reproducibility, responsible conduct of research, and health equity. By leveraging its nationwide group of mentors and trainees, Career MODE will also offer a structured approach to enhance collaborations and networking, help create teams for breakthrough research projects and K99/R00 and R01-type grant proposals, further career development, and help secure tenure-track positions and faculty promotions. Career MODE will feature hybrid (virtual and in-person) coursework and learning activities (boot camps, roundtables, panels, symposia, observerships), a robust evaluation of each objective, and will generate and disseminate extensive educational material on omics and data science. The program will do outreach to the most promising, motivated, and diverse junior investigators—a group traditionally with limited resources— to create empowered cohorts of scientists to pursue independence through advanced knowledge and tools in omics and data sciences applicable to all biomedical research fields. Thus, our program aligns with NIGMS goals and provides a high return for investment. We will also develop strategies to advance equity and access in omics research and promote Career MODE to academic institutions, sponsors, and stakeholders to reach financial sustainability and self-support beyond the five years of R25 funding.

项目概要/摘要 美国国家科学院描述了科学家在从导师指导的道路上经历的障碍 独立研究是美国生物医学科学未来面临的最严重威胁 各州（美国）。来自边缘群体的妇女和个人面临着更大的障碍，特别是在 尽管 NIH 有单独的拨款审查和支付线，但技术密集型领域，如组学科学。 调查人员收到第一张 R01 的平均年龄持续攀升至 46 岁的历史最高水平， 与此同时，博士毕业生成为教授的可能性也有所下降。 过去几十年来大幅下降，使美国生物医学研究的未来面临风险。 为了应对这些挑战，我们提出了“职业模式”计划：通过指导和职业发展 为早期研究人员提供组学和数据培训，以增强不同群体的年轻研究人员的能力 美国各地——即在指导培训的最后几年中的博士后和两年内的教员 他们的第一个任命是在组学和数据科学领域建立独立、成功的职业生涯。 从基因组学到微生物组，它们已经彻底改变了生物医学科学。 作为任何生物医学领域的一部分，每个学科内缺乏经过适当组学培训的劳动力 我们寻求制定一项为期 11 个月的计划，提供强化培训。 组学和数据科学以及由 70 多名导师组成的全国性多元化网络的专业指导。 MODE 还将提供专业技能培训，包括领导力和团队管理、资助 写作、指导、目标设定和战略制定、沟通和教学、科学严谨性、 透明度、可重复性、负责任的研究行为和健康公平性。 由导师和学员组成的团体，职业模式还将提供结构化方法来加强合作 和网络，帮助创建突破性研究项目团队以及 K99/R00 和 R01 型资助 提案，进一步职业发展，并帮助获得终身教职和教师晋升。 职业模式将以混合（虚拟和面对面）课程和学习活动（训练营、 圆桌会议、小组讨论、专题讨论会、观察员），对每个目标进行强有力的评估，并将产生和 该计划将广泛传播有关组学和数据科学的教育材料。 最有前途、最有动力、最多元化的初级研究者——传统上资源有限的群体—— 创建有能力的科学家群体，通过先进的知识和工具追求独立 组学和数据科学适用于所有生物医学研究领域，因此，我们的计划与 NIGMS 保持一致。 我们还将制定促进公平和准入的战略。 组学研究并向学术机构、赞助商和利益相关者推广职业模式，以达到 R25 资助五年后的财务可持续性和自我支持。