Extracellular vesicles in Environmental Epidemiology Studies of Aging

细胞外囊泡在衰老环境流行病学研究中的应用

基本信息

批准号：
10559268
负责人：
Andrea Baccarelli
金额：
$ 6.21万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-05 至 2029-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10559268
关键词：
Address Adverse effects Affect African American Age Age-Years Aging Air Air Pollution Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Area Automobile Driving Biological Markers Brain Calendar Caliber Caribbean Hispanic Cell physiology Cessation of life Cognition Cognitive Cognitive aging Collection Communities Data Dementia Dependence Diet Elderly Environmental Epidemiology Environmental Health Exposure to Faculty Family Funding Generations Grant Health Human Biology Impaired cognition Individual Intake Intervention Studies Lead Maps Master of Public Health Measures Mediating Mediation Mediator of activation protein Mentors Metabolic Pathway Molecular Molecular Epidemiology Nerve Degeneration Neurologic Examination Neuropsychology Neurosciences Not Hispanic or Latino Organism Oxidation-Reduction Parents Participant Particulate Matter Pathway interactions Plasma Play Population Post-Translational Protein Processing Prevention Proteins Public Health Public Health Schools Puerto Rican Research Research Training Resolution Role Schools Signal Transduction Source Statistical Data Interpretation Stress Supplementation Time Toxic effect Training Universities Washington Writing Xenobiotics aging brain amino acid metabolism base biomarker discovery career cognitive function cohort college data cleaning data management disease phenotype epidemiology study ethnic diversity experience extracellular vesicles falls fine particles health knowledge interest lifestyle factors lipid metabolism mass spectrometer medical examination mental state metabolome metabolomics microorganism molecular phenotype multi-ethnic novel parent grant pre-clinical premature prevent programs skills skills training undergraduate student

Address Adverse effects Affect African American Age Age-Years Aging Air Air Pollution Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Area Automobile Driving Biological Markers Brain Calendar Caliber Caribbean Hispanic Cell physiology Cessation of life Cognition Cognitive Cognitive aging Collection Communities Data Dementia Dependence Diet Elderly Environmental Epidemiology Environmental Health Exposure to Faculty Family Funding Generations Grant Health Human Biology Impaired cognition Individual Intake Intervention Studies Lead Maps Master of Public Health Measures Mediating Mediation Mediator of activation protein Mentors Metabolic Pathway Molecular Molecular Epidemiology Nerve Degeneration Neurologic Examination Neuropsychology Neurosciences Not Hispanic or Latino Organism Oxidation-Reduction Parents Participant Particulate Matter Pathway interactions Plasma Play Population Post-Translational Protein Processing Prevention Proteins Public Health Public Health Schools Puerto Rican Research Research Training Resolution Role Schools Signal Transduction Source Statistical Data Interpretation Stress Supplementation Time Toxic effect Training Universities Washington Writing Xenobiotics aging brain amino acid metabolism base biomarker discovery career cognitive function cohort college data cleaning data management disease phenotype epidemiology study ethnic diversity experience extracellular vesicles falls fine particles health knowledge interest lifestyle factors lipid metabolism mass spectrometer medical examination mental state metabolome metabolomics microorganism molecular phenotype multi-ethnic novel parent grant pre-clinical premature prevent programs skills skills training undergraduate student

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项目摘要

Project summary The main objective of this project is to investigate the role of plasma metabolites in the relationship between exposure to PM2.5 and cognitive function in an ethnically diverse aging cohort. This project is a supplement to an ongoing R35 that investigates the role of extracellular vesicles in the relationship between PM2.5 exposure and cognitive decline in the same cohort. The candidate for this supplement is an undergraduate student matriculating into the MPH program at Columbia University in the Fall of 2022. She is expected to graduate from Hunter College with a B.A. degree in Human Biology and Neuroscience in May 2022. The candidate is an American of Puerto Rican descent and the first generation in her family to attend graduate school. For her research and training, she will be mentored by Dr. Baccarelli, PI of the parent grant with support from two other faculty in the department (Dr. Miller and Dr. Kioumourtzoglou). In the proposed project, the candidate will (1) determine the association between exposure to PM2.5 and plasma metabolites, measured using untargeted metabolomics analysis, and characterize the metabolic pathways associated with PM2.5 exposure in the Washington Heights and Inwood Columbia Aging Project (WHICAP) cohort; (2) examine the relationship between plasma metabolites and global cognitive function, measured using mini mental state exam (MMSE) (3) Investigate whether plasma metabolites can mediate the relationship previously identified between PM2.5 and cognitive function in the WHICAP cohort. Through the proposed analyses, the candidate will gain experience and skills in: (1) data management and cleaning, (2) statistical analyses in molecular epidemiology, (3) mediation analysis in environmental epidemiology, (4) writing and communicating research findings. The candidate will also pursue formal training by take courses that are part of the MPH program during the regular school year. The candidate and mentor will meet once a week for training and to discuss progress.

项目摘要该项目的主要目的是研究等离子体代谢物在关系中的作用在种族多样化的衰老队列中，暴露于PM2.5和认知功能。这个项目是对正在进行的R35研究细胞外囊泡在PM2.5暴露与同一队列的认知能力下降。该补充的候选人是一名本科生 2022年秋天，哥伦比亚大学的MPH课程入学。预计她将毕业猎人学院拥有学士学位2022年5月的人类生物学和神经科学学位。候选人是一种波多黎各人的裔美国人和她家庭中的第一代人上研究生院。为她研究和培训，她将在父母赠款的PI Baccarelli博士的指导下进行指导。该系的教师（Miller博士和Kioumourtzoglou博士）。在拟议的项目中，候选人将（1）确定使用不靶向的PM2.5和血浆代谢产物之间的关联代谢组学分析，并表征与PM2.5暴露有关的代谢途径华盛顿高地和Inwood哥伦比亚老化项目（WHICAP）队列；（2）检查关系在血浆代谢产物和全球认知功能之间，使用迷你精神状态检查（MMSE）测量（3）研究血浆代谢物是否可以介导PM2.5和PM2.5之间的关系 WHICAP队列中的认知功能。通过拟议的分析，候选人将获得经验（1）数据管理和清洁，（2）分子流行病学的统计分析，（3）调解环境流行病学的分析，（4）撰写和交流研究结果。候选人会还可以通过常规学年的MPH计划一部分参加正规培训。候选人和导师将每周开会一次进行培训并讨论进度。