Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

为青少年和年轻人身体活动和久坐行为预防心血管疾病提供国家指南

• 批准号: 10283862
• 负责人: Jason M Nagata
• 金额: $ 17.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283862
• 关键词: Accounting; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; American; Area; Behavior; Biometry; Brain; COVID-19 pandemic; Cardiovascular Diseases; Cause of Death; Cessation of life; Clinical Trials; Coronary Artery Risk Development in Young Adults Study; Data; Data Science; Development; Development Plans; Diabetes Mellitus; Dose; Early Intervention; Elderly; Epidemiologist; Event; Exposure to; Future; Grant; Growth and Development function; Guidelines; Health; Health Benefit; Heart Diseases; Human; Hyperlipidemia; Hypertension; Incidence; Intervention; Knowledge; Life; Link; Longitudinal Studies; Longitudinal cohort; Measurement; Medicine; Mentors; Mentorship; Methods; Modeling; Modification; Myocardial Infarction; National Heart, Lung, and Blood Institute; Pattern; Physical activity; Physicians; Population; Premature Mortality; Prevention; Public Health; Recommendation; Research Priority; Resource Allocation; Rest; Risk; Risk Factors; Services; Specific qualifier value; Stroke; Testing; Text Messaging; Time; Training; United States; United States Dept. of Health and Human Services; Video Games; Videoconferencing; Visual impairment; age group; base; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cognitive development; cohort; evidence base; experience; implementation science; longitudinal analysis; markov model; meetings; mortality; physical inactivity; prevent; sedentary; sedentary lifestyle; skills; social media; symposium; tv watching; young adult

PROJECT SUMMARY / ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity and sedentary behavior during adolescence and young adulthood if risk for concurrent and future CVD is to be averted, and were specifically identified as priority research areas in the 2018 Department of Health and Human Services (HHS) Physical Activity Guidelines for Americans. Adolescence and young adulthood are critical transition periods that set physical activity patterns for the rest of adulthood and may represent a critical window for early intervention. The overall objective of this K08 is to develop evidence to bridge the HHS-articulated gaps by describing independent effects of sedentary behavior in adolescence and thresholds of physical activity in young adulthood on the prevention of later-life CVD to inform future HHS guidelines. The central hypothesis is that highly sedentary adolescents and young adults will require higher physical activity levels to reduce CVD risk in later adulthood. This project will analyze longitudinal cohort data from the Adolescent Brain Cognitive Development (ABCD) Study, the National Longitudinal Study of Adolescent to Adult Health (Add Health), and the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The Specific Aims will: (1) determine independent associations of contemporary forms of sedentary behavior (screen time) in adolescents with CVD risk factor incidence; (2) evaluate associations of attaining HHS-recommended adolescent (60 mins/day, 7 days/week) versus adult (30 mins/day, 5 days/week) physical activity levels during specific age ranges in young adulthood with incidence of CVD risk factors; and (3) estimate population-level lifetime effects of adolescent and young adult sedentary behaviors, physical activity dose, and their interactions on later-life CVD mortality. The candidate’s long-term career objective is to become an independent physician-epidemiologist generating actionable evidence to optimize adolescent and young adult behaviors to prevent CVD later in life. The proposed career development plan will provide training and mentorship in: (1) physical activity, sedentary behavior, and CVD epidemiology and measurement; (2) longitudinal analyses and modeling methods; (3) guideline development and implementation; and (4) career development and plan for independence. Training will be achieved through coursework, seminars, tutorials, conferences, hands-on experience, and active mentoring. The mentoring team includes nationally recognized experts in cardiovascular epidemiology, adolescent and young adult medicine, physical activity/sedentary behavior, biostatistics, guideline development, and implementation science. Completion of this K08 will inform specific guidance for adolescents and young adults in the next edition of the Physical Activity Guidelines for Americans. The K08 will support a future R01 grant using implementation science and modeling approaches to promote attainment of national physical activity guidelines to prevent CVD, aligned with NHLBI’s strategic vision of reducing heart disease through data and implementation science.

项目概要/摘要 心血管疾病 (CVD) 是美国的首要死因，体力活动是一个重要的原因 我们对体力活动最佳持续时间的理解仍然存在严重差距。 以及青春期和青年期的久坐行为，如果同时发生和未来发生 CVD 的风险 避免了这一问题，并被明确确定为 2018 年卫生与人类健康部的优先研究领域 服务 (HHS) 美国人的身体活动指南至关重要。 过渡期为成年期的其余时间设定身体活动模式，并且可能代表一个关键的窗口期 K08 的总体目标是寻找证据来弥合 HHS 明确的差距。 通过描述青春期久坐行为的独立影响和体力活动阈值 青年期预防晚年 CVD 为未来 HHS 指南提供信息的中心假设是。 久坐的青少年和年轻人需要更高的体力活动水平来降低心血管疾病风险 该项目将分析青少年大脑认知的纵向队列数据。 发展 (ABCD) 研究、全国青少年至成人健康纵向研究（Add Health）以及 年轻人冠状动脉风险发展 (CARDIA) 研究的具体目标将： (1) 确定。 患有心血管疾病的青少年当代形式的久坐行为（屏幕时间）的独立关联 危险因素发生率；(2) 评估与达到 HHS 建议的青少年（60 分钟/天，7 天/周）与成人（30 分钟/天，5 天/周）在特定年龄范围内的青少年体力活动水平 成年期 CVD 危险因素的发生率；以及 (3) 估计青少年和青少年对人群一生的影响； 年轻人的久坐行为、体力活动剂量及其对晚年 CVD 死亡率的相互作用。 候选人的长期职业目标是成为一名独立的医生流行病学家，产生 优化青少年和年轻人行为以预防晚年心血管​​疾病的可行证据。 职业发展计划将提供以下方面的培训和指导：(1) 身体活动、久坐行为和 CVD流行病学和测量；（2）纵向分析和建模方法；（3）指南 制定和实施；以及（4）职业发展和独立培训计划。 通过课程作业、研讨会、教程、会议、实践经验和积极指导来实现。 指导团队包括全国公认的心血管流行病学、青少年和青少年专家 成人医学、体力活动/久坐行为、生物统计学、指南制定和实施 完成本 K08 将为下一版中的青少年和年轻人提供具体指导。 K08 将通过实施来支持未来的 R01 拨款。 科学和建模方法，以促进实现国家身体活动指南，以预防心血管疾病， 符合 NHLBI 通过数据和实施科学减少心脏病的战略愿景。