Development of Online Tool for Speech-Language Research

言语研究在线工具的开发

• 批准号: 10289323
• 负责人: Hope Sparks Lancaster
• 金额: $ 12.22万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-27 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10289323
• 关键词: Adult; Affect; Behavioral; Child; Clinical; Clinical Research; Communication; Copyright; Data Collection; Development; Diagnosis; Diagnostic; Disease; Dyslexia; Ensure; Etiology; Face; Feedback; General Population; Genetic; Genetic Research; Genetic study; Goals; Health; High Prevalence; Home environment; Individual; Instruction; Language; Language Development Disorders; Language Disorders; Measures; Meta-Analysis; Methods; Modeling; Normal Range; Participant; Pathologist; Perception; Performance; Pilot Projects; Population; Property; Psychiatrist; Psychologist; Reading; Reading Disorder; Recording of previous events; Reporting; Research; Research Design; Resources; Sampling; Sampling Studies; Speech; Speech Disorders; Speech Sound; Telephone; Testing; Variant; Work; base; clinically relevant; cognitive interview; cohort; comorbidity; design; experience; genetic analysis; improved; reading ability; recruit; research study; skills; spelling; tool; trait

Speech and language disorders, including severe speech sound disorder (SSD), developmental language disorder (DLD), and dyslexia, affect nearly 30% of the population. Despite the high prevalence of these disorders, we do not have a clear understanding of the genetic basis of speech, language, and reading abilities or disorders. In part, this gap in our understanding is due to the lack of sufficiently large samples to conduct robust genetic analyses (e.g., 100,000). We could increase our understanding of the genetics by using large research cohorts like 23andMe, All of Us, and the UK Bio Bank. We are currently unable take advantage of such cohorts because we lack a quick, reliable, and valid online tool capable of measuring speech, language, and reading skills in adults. The overall goal of this proposal is to develop an online behavioral data collection tool for speech-language genetics research. We will adapt, refine, and pilot test online versions of existing speech, language, and reading measures for online testing with adults. The long-term goal is to use this online behavioral tool to examine the genetics of speech, language, and reading traits within large pre-existing genetic cohorts to further our understanding of the genetics of speech and language traits and disorders. There are three specific aims. Specific aim 1 is to adapt and refine speech, language, and reading measures. This aim includes modifying existing tools, creating new test items, and obtaining expert and user feedback. Specific aim 2 will pilot test the online tool in a general population sample (n = 100), examine performance distribution, and provide an estimate for convergent validity. Specific aim 3 will pilot test the online tool in a clinical sample (n = 60) with SSD, DLD, or dyslexia. We will examine performance in each clinical group, demonstrate initial validity, and identify tasks with potential to differentiate between groups.

言语和语言障碍，包括严重的言语障碍（SSD），发育 语言障碍（DLD）和阅读障碍会影响近30％的人口。尽管患病率很高 在这些疾病中，我们对语音，语言和语言的遗传基础没有清楚的了解 阅读能力或疾病。在某种程度上，我们的理解差距是由于缺乏足够大的 样品进行强大的遗传分析（例如100,000）。我们可以增加对 通过使用大型研究队列（例如23andme），我们所有人和英国生物银行（Brans Bank），遗传学。我们是 目前无法利用此类队列，因为我们缺乏快速，可靠且有效的在线工具 能够测量成人的语音，语言和阅读技能。该提议的总体目标是 为语音语言遗传学研究开发在线行为数据收集工具。我们将 适应现有语音，语言和阅读措施的在线版本 与成人进行在线测试。长期目标是使用此在线行为工具来检查 言语，语言和阅读特征的遗传学在大型遗传人群中，以进一步 了解语音，语言特征和疾病的遗传学。有三个特定的 目标。具体目标1是适应和完善语音，语言和阅读措施。这个目标包括 修改现有工具，创建新的测试项目，并获得专家和用户反馈。具体目标2 将在一般人群样本（n = 100）中进行试验测试在线工具，检查性能分布， 并提供收敛有效性的估计值。特定目标3将试行临床中的在线工具 SSD，DLD或阅读障碍的样品（n = 60）。我们将检查每个临床组的表现， 证明初始有效性，并确定具有区分各组潜力的任务。