Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network

阐明端粒的测量：建立跨学科、高影响力的端粒研究网络

• 批准号: 10219955
• 负责人: Stacy Schmidt Drury
• 金额: $ 49.55万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219955
• 关键词: Address; Advisory Committees; Aging; Air Pollution; Americas; Basic Science; Biological; Biological Assay; Biological Markers; Biometry; Cardiovascular Diseases; Clinical Research; Collaborations; Data; Databases; Development; Discipline; Disease; Disease susceptibility; Educational workshop; Effectiveness; Ensure; Environmental Exposure; Evaluation; Explosion; Fostering; Future; Goals; Gold; Grant; Health; Individual; Infrastructure; Laboratories; Length; Life; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mental Depression; Methodology; Methods; Modeling; National Institute of Environmental Health Sciences; Network Infrastructure; Onset of illness; Outcome; Pathway interactions; Persons; Pilot Projects; Population; Population Study; Predictive Value; Prevention; Procedures; Process; Protocols documentation; Psychosocial Stress; Reporting; Reproducibility; Research; Research Personnel; Risk; Sampling; Schizophrenia; Scientific Advances and Accomplishments; Scientist; Sentinel; Shapes; Stress; Telomerase; Testing; Training; Translational Research; Validation; age related; base; biological specimen archives; cohort; disorder risk; early life exposure; early life stress; expectation; healthspan; innovation; interest; meetings; mortality; next generation; novel; population based; psychosocial; recruit; research study; sample collection; telomere; virtual; web site

PROJECT SUMMARY The proposed Telomere Research Network (TRN) will establish best practices related to telomere length (TL) measurement applicable to population-based studies and will define the extent to which TL can be effectively applied as a sentinel of aging-related disease risk and indicator of environmental and psychosocial stress exposure across the life span. Across scientific fields, the use of telomeres as a marker of exposure and a harbinger of disease risk and accelerated aging is expanding. The explosion of telomere research, while promising, has raised methodological and reporting concerns triggered by inconsistent reproducibility. To address these concerns and advance telomere research, this U24 proposes the following specific AIMS: 1) Create a living network of invested stakeholders to address challenges in determining the extent to which TL is a sentinel of environmental exposures, psychosocial stress, and disease susceptibility; and to ensure the highest rigor and reproducibility in current and future telomere studies. 2) Support and coordinate U01 efforts by ensuring seamless sharing of samples, data, and protocols and fostering interactive discussions focused on best practices for TL measurement. 3) Facilitate the infrastructure for sustained cross-discipline dialogue, dissemination, and research related to TL as a sentinel of cumulative exposure and a predictor of health and aging. To achieve these AIMS, the U24 proposes to recruit a diverse and interactive network of scientists invested in resolving methodologic concerns in TL metrics; engage in formal testing of the extent to which TL, telomerase and other telomere indicators serve as sentinels of age-related disease and cumulative exposures; and define best practices for TL measured in population studies. These AIMS will produce clear methodologic standards, pipelines for increased cross-study analyses and collaboration, and a sustainable platform for continued dialogue related to the measurement of TL and its implications for aging, exposure, and stress research.

项目摘要 拟议的端粒研究网络（TRN）将建立与端粒长度有关的最佳实践（TL） 适用于基于人群的研究的测量，并将定义可以有效地应用TL的程度 与衰老相关的疾病风险的前哨以及整个生命周期环境和社会心理压力暴露的指标。 在整个科学领域，将端粒用作暴露的标志和疾病风险和加速衰老的预兆 正在扩展。端粒研究的爆炸虽然有前途，但提出了方法论和报告问题 由不一致的可重复性触发。为了解决这些问题并提高端粒研究，该U24提出了 以下具体目的：1）创建一个活着的投资利益相关者网络，以应对确定的挑战 TL是环境暴露，社会心理压力和疾病易感性的延期范围；并确保 在当前和未来的端粒研究中，严格和可重复性最高。 2）支持和协调U01的努力 确保无缝共享样本，数据和协议，并促进互动讨论，重点是最佳实践 用于TL测量。 3）促进基础设施进行持续的跨学科对话，传播和研究 与TL作为累积暴露的前哨以及健康和衰老的预测因子有关。为了实现这些目标，U24 提议招募一个多样化的互动网络，这些网络投资于解决TL的方法论问题 指标；对TL，端粒酶和其他端粒指标作为哨兵的正式测试 与年龄有关的疾病和累积暴露；并定义了在人群研究中测得的TL的最佳实践。这些 AIMS将产生明确的方法论标准，以增加跨研究分析和协作的管道，以及 可持续平台继续对话，与TL的测量及其对衰老，接触和含义的影响有关 压力研究。