Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network

阐明端粒的测量：建立跨学科、高影响力的端粒研究网络

• 批准号: 10346650
• 负责人: Stacy Schmidt Drury
• 金额: $ 6.6万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10346650
• 关键词: Achievement; Address; African American; Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; American; Area; Auditory; Biological Markers; Caring; Cerebrospinal Fluid; Clinical Trials; Cognitive aging; Complex; Coupled; DNA Methylation; Data; Dementia; Detection; Development; Discipline; Disease; Disease susceptibility; Doctor' s Degree; Elderly; Ensure; Environmental Exposure; Epigenetic Process; Etiology; European; Family; Female; Funding; Goals; Impaired cognition; Individual; International; Length; Leukocytes; Life Cycle Stages; Longitudinal prospective study; Measurement; Measures; Minority Enrollment; Minority Groups; Native Americans; Neuropsychology; Neurosciences; Oneida; Outcome; Parents; Performance; Peripheral; Population; Population Study; Psychosocial Stress; Reproducibility; Research; Research Personnel; Risk; Scientist; Sentinel; Societies; Testing; Trail Making Test; Training; Tribes; United States National Institutes of Health; Universities; Verbal Learning; base; career; career development; cell age; cognitive change; cognitive performance; doctoral student; graduate student; high risk; interest; member; middle age; outreach; parent grant; peripheral blood; programs; racial and ethnic; specific biomarkers; telomere

PROJECT SUMMARY This diversity supplement will support the career development for Lauren W. Yowelunh McLester-Davis, a member of the Oneida tribe and the only Native American graduate student at Tulane University. Given the paucity of Native Americans receiving doctoral degrees and NIH funding over the last decade, early targeted support, particularly for exceptionally qualified female Native American researchers in STEMM fields, is critical. This supplement will support one such candidate through a research program directly aligned with her own career goals and key professional interest areas by the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment – specifically the relation between disease detection, biomarkers and diversity, and ethnoracial factors related to Alzheimer's disease and related disorders (ADRD). The proposed supplement is aligned with the parent U24 (U24AG066528), that established the Telomere Research Network (TRN) to determine best practices for measurement of telomere length (TL) applicable to population-based studies and determine the ability of TL to serve a sentinel of the environmental exposome, psychosocial stress, and disease susceptibility across the life course. The proposed supplement will expand the aims of the parent grant with the following supplemental AIMS: Aim 1: To determine the relationship between TL and neuropsychological performance in African American and Native American middle-aged and older adults. It is hypothesized that the Rey Auditory Verbal Learning Test (RAVLT) and the Trail Making Test (TMT), which capture subtle cognitive changes associated with ADRD, will be significantly associated with peripheral blood TL within African and Native Americans. Aim 2a: To assess the correlation between TL in CSF and peripheral blood. It is hypothesized that TL measured in peripheral blood with be significantly correlated with TL measured from TL measured from white blood cells (WBCs) obtained from cerebrospinal fluid (CSF). Aim 2b: To assess the correlation of TL with DNA methylation- based age (DNAm age) from cells in CSF in middle-aged and older adults. It is hypothesized that TL will be associated with DNAm age and that CSF TL will demonstrate a stronger correlation with DNAm age in CSF WBCs than TL measured in peripheral WBC. Together the achievement of these Aims is expected to contribute to an enhanced understanding of relation between TL and with neuropsychological outcomes in minoritized populations and specific biomarkers of ADRD.

项目摘要 这种多样性补充将支持劳伦·Yowelunh的职业发展 麦克莱斯·戴维斯（McLester-Davis），奥尼达部落的成员，也是唯一的美国原住民研究生 在杜兰大学。考虑到获得博士学位和NIH的美洲原住民很少 在过去十年中的资金，较早的针对性支持，特别是针对特殊资格的 Stemm领域的美国原住民研究人员至关重要。这种补充将支持 一个这样的候选人通过直接与自己的职业目标保持一致的研究计划和 阿尔茨海默氏症协会国际协会的主要专业利益领域促进 阿尔茨海默氏症的研究和治疗 - 特别是疾病检测之间的关系， 生物标志物和多样性以及与阿尔茨海默氏病及其相关的民族因素 疾病（ADRD）。所提出的补充剂与母公司U24（U24AG066528）对齐， 建立了端粒研究网络（TRN），以确定 端粒长度（TL）适用于基于人群的研究的测量，并确定 TL服务环境宣传体，社会心理压力和 整个生活过程中的疾病敏感性。拟议的补充剂将扩大 以下补充目的的父母赠款：目标1：确定关系 在非裔美国人和本地的TL和神经心理学表现之间 美国中年和老年人。假设Rey听觉口头 学习测试（RAVLT）和步道制作测试（TMT），捕获微妙的认知 与ADRD相关的变化将与外周血TL显着相关 非洲和美洲原住民。目标2a：评估CSF和CSF中TL之间的相关性 外周血。假设在外周血中测得的TL显着 与从从白细胞（WBC）中测得的TL测得的TL相关 脑脊液（CSF）。 AIM 2B：评估TL与DNA甲基化的相关性 中年和老年人中CSF细胞的基于年龄（DNAM年龄）。这是 假设TL将与DNAM年龄有关，CSF TL将证明 与外围WBC中测得的TL相比，与CSF WBC中DNAM年龄的相关性更强。 预计这些目标的实现将有助于增强 理解TL和与少数化神经心理学结果之间的关系 ADRD的人群和特定的生物标志物。