Culturally-targeted communication to promote SARS-CoV-2 antibody testing in saliva: Enabling evaluation of inflammatory pathways in COVID-19 racial disparities

以文化为目标的沟通促进唾液中 SARS-CoV-2 抗体检测：能够评估 COVID-19 种族差异中的炎症途径

• 批准号: 10221254
• 负责人: Todd William Lucas
• 金额: $ 132.64万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221254
• 关键词: 2019-nCoV; African American; Anti-Inflammatory Agents; Antibodies; Attenuated; Attitude; Behavior; Biological Assay; Biological Markers; Biological Process; Biological Sciences; COVID-19; COVID-19 pandemic; Cities; Clinical; Cognition; Collaborations; Collection; Communication; Communities; Early Diagnosis; Evaluation; Funding; Goals; Health; Health Communication; Health Resources; Healthcare; Herd Immunity; Home environment; Incidence; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Knowledge; Lead; Link; Malignant Neoplasms; Measures; Medical; Methods; Michigan; Mission; Pathway interactions; Population; Prevalence; Process; Public Health; Race; Recovery; Registries; Research; Research Personnel; Risk; Role; Route; Saliva; Salivary; Serological; Services; Severities; Skin; Testing; United States; Water; biobehavior; experience; grasp; improved; innovation; insight; interest; mortality; novel; programs; racial difference; racial disparity; racial minority; racism; response; screening; social health determinants; stem; transmission process; uptake

Project Summary African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. SARS-CoV-2 disparities stem from many interconnected causes. Yet, connections to inflammatory biological processes in COVID-19 disparities remain largely unknown. Evaluating inflammatory responses can be facilitated by SARS-CoV-2 antibody testing, which can be used to identify and compare inflammation among those with and without confirmed SARS-CoV-2 infection, and to conduct cross-race comparisons of inflammatory factors. However, African Americans will be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism that are salient in the COVID-19 era. There is thus an urgent need to develop and deploy culturally-relevant communication and antibody testing programs. Our long-term goal is to identify and reduce unjust COVID-19 racial disparities. The immediate objective is to better encourage understanding and uptake of SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner, and when non-invasive salivary collection methods and assays are used. Our rationale is that combining culturally effective health communication with salivary testing will reduce mistrust and promote uptake that can lead to better grasping the role of inflammation in COVID-19 disparities. Our aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents’ antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally- targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing; 3) measure and identify multi-analyte inflammatory biomarker profiles among Flint Registry enrollees who complete salivary antibody testing and compare inflammatory biomarker profiles by race and antibody status. In collaboration with clinical and community partners, we will prepare and evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry – a highly visible local health resource exchange. In collaboration with leading salivary bioscience experts, we will furnish an opportunity to engage in at-home salivary antibody screening – a non-invasive route to antibody testing that is highly suited to disparities- oriented COVID-19 research. The proposed research is innovative and significant in highlighting that culturally- targeted communication and non-invasive antibody testing are vital to propelling disparities-oriented inflammatory COVID-19 research. Knowledge to be gained includes video tutorials and insights about community-facing salivary collection that can be immediately disseminated across SeroNet to better promote including racial monitories in ongoing studies of inflammation and antibody testing.

项目摘要 非裔美国人发展和死于SARS-COV-2感染比联合的任何其他种族群体都要多 国家，包括密歇根州弗林特等大多数非裔美国城市。 SARS-COV-2差异源于 许多相互联系的原因。然而，与19个分布中的炎症生物学过程的连接 仍然是未知的。可以通过SARS-COV-2抗体制备评估炎症反应 测试，可用于识别和比较有和没有确认的患者之间的感染 SARS-COV-2感染，并进行炎症因子的交叉赛车比较。但是，非洲 由于医疗不信任和 种族主义的经历在19世纪时代是显着的。因此，迫切需要发展和 部署与文化相关的沟通和抗体测试计划。我们的长期目标是确定和 减少不公正的Covid-19种族分布。直接目标是更好地鼓励理解和 摄取SARS-COV-2抗体测试。中心假设是非裔美国人将接受 何时以文化有效的方式传达福利和限制的抗体测试，何时 使用非侵入性唾液收集方法和测定法。我们的理由是在文化上结合 与唾液测试进行有效的健康沟通将减少Mildrust并促进吸收，这可能导致 更好地掌握炎症在19009差距中的作用。我们的目标是1）开发和比较 关于非裔美国人和白色flint的一般性与文化定位的视频的影响 居民的抗体测试参加并吸收； 2）确定并比较一般性与文化的影响 针对非洲裔美国人的医学不信任和与种族主义有关的认知的针对性视频 考虑抗体测试； 3）测量和识别Flint中的多分析物炎症生物标志物谱 注册表招募了完成唾液抗体测试的注册表，并通过 种族和抗体状态。与临床和社区合作伙伴合作，我们将准备和评估 有关SARS-COV-2抗体测试的一般和文化定位的视频教程。这些简短的视频将是 通过Flint注册中心分发给Flint社区，这是一种高度可见的当地卫生资源交换。 与领先的唾液生物科学专家合作，我们将提供一个机会 唾液抗体筛选 - 一种非常适合差异的抗体测试的非侵入性途径 - 定向的Covid-19研究。拟议的研究在强调文化上具有创新性和重要 有针对性的通信和非侵入性抗体测试对于以促进分布为导向至关重要 炎症性共同研究19。获得的知识包括有关视频教程和有关的见解 面向社区的唾液收集，可以立即在Seronet上传播以更好地促进 包括种族监测在正在进行的炎症和抗体测试的研究中。