Culturally-targeted communication to promote SARS-CoV-2 antibody testing in saliva: Enabling evaluation of inflammatory pathways in COVID-19 racial disparities

以文化为目标的沟通促进唾液中 SARS-CoV-2 抗体检测：能够评估 COVID-19 种族差异中的炎症途径

• 批准号: 10221254
• 负责人: Todd William Lucas
• 金额: $ 132.64万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221254
• 关键词: 2019-nCoV; African American; Anti-Inflammatory Agents; Antibodies; Attenuated; Attitude; Behavior; Biological Assay; Biological Markers; Biological Process; Biological Sciences; COVID-19; COVID-19 pandemic; Cities; Clinical; Cognition; Collaborations; Collection; Communication; Communities; Early Diagnosis; Evaluation; Funding; Goals; Health; Health Communication; Health Resources; Healthcare; Herd Immunity; Home environment; Incidence; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Knowledge; Lead; Link; Malignant Neoplasms; Measures; Medical; Methods; Michigan; Mission; Pathway interactions; Population; Prevalence; Process; Public Health; Race; Recovery; Registries; Research; Research Personnel; Risk; Role; Route; Saliva; Salivary; Serological; Services; Severities; Skin; Testing; United States; Water; biobehavior; experience; grasp; improved; innovation; insight; interest; mortality; novel; programs; racial difference; racial disparity; racial minority; racism; response; screening; social health determinants; stem; transmission process; uptake

Project Summary African Americans develop and die from SARS-CoV-2 infection more than any other racial group in the United States, including in majority African American cities such as Flint, Michigan. SARS-CoV-2 disparities stem from many interconnected causes. Yet, connections to inflammatory biological processes in COVID-19 disparities remain largely unknown. Evaluating inflammatory responses can be facilitated by SARS-CoV-2 antibody testing, which can be used to identify and compare inflammation among those with and without confirmed SARS-CoV-2 infection, and to conduct cross-race comparisons of inflammatory factors. However, African Americans will be reluctant to partake in conventional antibody testing programs due to medical mistrust and experiences with racism that are salient in the COVID-19 era. There is thus an urgent need to develop and deploy culturally-relevant communication and antibody testing programs. Our long-term goal is to identify and reduce unjust COVID-19 racial disparities. The immediate objective is to better encourage understanding and uptake of SARS-CoV-2 antibody testing. The central hypothesis is that African-Americans will be receptive to antibody testing when benefits and limitations are communicated in a culturally effective manner, and when non-invasive salivary collection methods and assays are used. Our rationale is that combining culturally effective health communication with salivary testing will reduce mistrust and promote uptake that can lead to better grasping the role of inflammation in COVID-19 disparities. Our aims are to 1) develop and compare effects of a general versus culturally-targeted video about antibody testing on African American and White Flint residents’ antibody testing attitudes and uptake; 2) identify and compare effects of a general versus culturally- targeted video on activation of medical mistrust and racism-related cognition among African Americans when considering antibody testing; 3) measure and identify multi-analyte inflammatory biomarker profiles among Flint Registry enrollees who complete salivary antibody testing and compare inflammatory biomarker profiles by race and antibody status. In collaboration with clinical and community partners, we will prepare and evaluate general and culturally-targeted video tutorials about SARS-CoV-2 antibody testing. These brief videos will be distributed to the Flint community through the Flint Registry – a highly visible local health resource exchange. In collaboration with leading salivary bioscience experts, we will furnish an opportunity to engage in at-home salivary antibody screening – a non-invasive route to antibody testing that is highly suited to disparities- oriented COVID-19 research. The proposed research is innovative and significant in highlighting that culturally- targeted communication and non-invasive antibody testing are vital to propelling disparities-oriented inflammatory COVID-19 research. Knowledge to be gained includes video tutorials and insights about community-facing salivary collection that can be immediately disseminated across SeroNet to better promote including racial monitories in ongoing studies of inflammation and antibody testing.

项目概要 非裔美国人死于 SARS-CoV-2 感染的人数比美国任何其他种族群体都要多 各州，包括密歇根州弗林特等大多数非裔美国城市，SARS-CoV-2 的差异源于此。 然而，COVID-19 与炎症生物过程的联系存在差异。 SARS-CoV-2 抗体是否可以促进炎症反应的评估仍知之甚少。 测试，可用于识别和比较已确诊和未确诊患者的炎症 SARS-CoV-2感染，并进行炎症因子的跨种族比较。 由于对医疗的不信任和 因此，迫切需要开发和利用新冠病毒 (COVID-19) 时代突出的种族主义经历。 我们的长期目标是识别和部署与文化相关的沟通和抗体测试计划。 减少不公正的 COVID-19 种族差异。当前的目标是更好地鼓励理解和支持。 核心假设是非裔美国人会接受 SARS-CoV-2 抗体检测。 当以文化上有效的方式传达好处和限制时，以及当 我们使用非侵入性唾液采集方法和检测的理由是结合文化。 通过唾液检测进行有效的健康沟通将减少不信任并促进采用，从而导致 更好地了解炎症在 COVID-19 差异中的作用 我们的目标是 1) 开发和比较。 关于非裔美国人和白弗林特人抗体测试的一般视频与文化目标视频的影响 居民对抗体检测的态度和接受情况；2) 识别并比较一般抗体检测与文化抗体检测的效果； 关于激活非裔美国人中的医疗不信任和种族主义相关认知的有针对性的视频 考虑抗体测试；3) 测量和识别弗林特的多分析物炎症生物标志物谱 完成唾液抗体测试并比较炎症生物标志物概况的注册登记者 我们将与临床和社区合作伙伴合作，准备和评估。 有关 SARS-CoV-2 抗体测试的一般性和针对文化的视频教程这些简短的视频将是。 通过弗林特登记处（一个高度可见的当地卫生资源交换机构）分发给弗林特社区。 与领先的唾液生物科学专家合作，我们将提供在家参与的机会 唾液抗体筛查——一种非常适合差异的非侵入性抗体检测途径—— 拟议的研究具有创新性，并且在强调文化方面具有重要意义。 有针对性的沟通和非侵入性抗体检测对于推动差异导向至关重要 获得的知识包括视频教程和相关见解。 面向社区的唾液采集，可以立即在 SeroNet 上传播，以更好地宣传 包括正在进行的炎症和抗体测试研究中的种族监测。