Cognitive Phenotype Neural Circuitry in Vivo In Mood Disorders and Suicidal Behavior

情绪障碍和自杀行为中的体内认知表型神经回路

基本信息

批准号：
10207366
负责人：
KEVIN N OCHSNER
金额：
$ 12.46万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-19 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10207366
关键词：
Address Affective Aggressive behavior Amygdaloid structure Anterior Anxiety Disorders Autopsy Aversive Stimulus Behavioral Binding Biological Borderline Personality Disorder Brain Chronic stress Clinical Cognitive Color Data Depression and Suicide Disease Down-Regulation Emotional Emotions Episodic memory Event Exposure to Feeling suicidal Functional disorder Funding Future Generations Hippocampus (Brain)Hydrocortisone Image Impulsivity Individual Individual Differences Lateral Lead Measures Memory Mental Depression Modeling Monoamine Oxidase A Mood Disorders Neurobiology Patient Self-Report Pattern Phenotype Play Positron-Emission Tomography Reaction Regulation Reporting Research Risk Role Sampling Self Destructive Behavior Stimulus Stress Structure Suicide Suicide attempt System Testing Trier Social Stress Test Variant Work biological adaptation to stress brain dysfunction clinically relevant cognitive control emotion regulation experience hypothalamic-pituitary-adrenal axis in vivo negative affect negative emotional state negative mood neural circuit neuroinflammation neuromechanism novel psychologic recruit relating to nervous system response social stressor stress reactivity stressor suicidal behavior suicidal risk suicide attempter suicide model trait

项目摘要

SUMMARY – PROJECT 4 How we respond to negative events, regulate our responses to them, and later remember them – plays a central role in mood and/or anxiety disorders, such as depression, and can lead individuals to engage in self- destructive behaviors, including suicide. As such, a critical question for research is what psychological and neural mechanisms generate our initial response to an aversive event, encode that event into memory, and enable us to regulate our response to it. In the current funding period, we began addressing these issues by examining the relationship between MDD, suicide risk, and the generation and regulation of responses to normatively negative and positive stimuli. In this renewal, three factors guide our continued focus on negative emotional reactivity and regulation as well as a new focus on memory. First, in the current funding period we found that responses to aversive stimuli were most strongly related to clinically relevant variables collected in Ps 1, 3 and 5. Second, to capture idosyncratically self-relevant negative responses that may be relevant to suicide risk, we developed a novel variant of our emotion regulation task that involved recollecting unpleasant autobiographical memories and in pilot data found that it was sensitive to MDD vs. control differences in amygdala and hippocampal function. Third, chronic stress is known to impact structural integrity of the PFC and hippocampus via HPA axis activation and neuroinflammation, and postmortem P1 data has identified such changes in suicide decedents. Given these data, in this proposal we focus on studying how MDD and suicide risk are related to PFC, amygdala and hippocampal systems, in the context of: (Aim 1) recollecting and regulating responses to aversive autobiographical memories, (Aim 2) generating enduring negative emotional states that may carry over to subsequent neutral experiences and color memory for them, and understanding how individual differences in clinical and biological variables collected under Projects 3 and 5 relate to data collected under Aims 1 and 2.

摘要 - 项目4 我们如何应对负面事件，调节我们对它们的反应，然后记住它们 - 扮演在情绪和/或焦虑症（例如抑郁症）中的核心作用，可以使个人参与自我破坏性行为，包括自杀。因此，研究的关键问题是什么心理和神经机制会产生我们对厌恶事件的初始响应，将该事件编码到内存中，然后使我们能够规范我们对此的反应。在当前的资金期间，我们开始通过检查MDD，自杀风险以及对响应的产生和调节之间的关系通常为负和阳性刺激。在此续签中，三个因素指导我们继续关注负面情绪反应性和调节以及对记忆的新关注。首先，在当前的资金期间我们发现对厌恶刺激的反应与收集的临床相关变量最密切相关 ps 1、3和5。第二，捕获可能与自杀风险，我们开发了一种新颖的情绪调节任务变体，涉及回忆不愉快自传记忆和试验数据发现，它对MDD和控制差异敏感杏仁核和海马功能。第三，已知慢性应激会影响PFC的结构完整性和海马通过HPA轴激活和神经炎症，以及验尸P1数据已确定自杀的变化决定。鉴于这些数据，在此提案中，我们专注于研究MDD和自杀在以下情况下，风险与PFC，杏仁核和海马系统有关调节对厌恶自传记忆的反应，（目标2）产生持久的负面情绪可能会延续到随后的中性体验和色彩记忆的状态，并理解项目3和5下收集的临床和生物变量的个体差异与数据如何相关根据目标1和2收集。