Understanding the role of dysregulation in positive affect in developmental psychopathology.

了解失调在发展精神病理学中积极影响中的作用。

• 批准号: 10701035
• 负责人: Alecia C. Vogel
• 金额: $ 19.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701035
• 关键词: 10 year old; Address; Affect; Affective; Age; Aggressive behavior; Amygdaloid structure; Anterior; Behavior; Behavioral; Child; Childhood; Clinical; Data; Depressed mood; Development; Diagnostic; Diagnostics Research; Dimensions; Disease; Disruptive Behavior Disorder; Down-Regulation; Early Intervention; Early identification; Emotional; Emotions; Factor Analysis; Fright; Functional Magnetic Resonance Imaging; Goals; Health; Impairment; Individual; Individual Differences; Infant; Intervention; Interview; Left; Literature; Manic; Measurement; Measures; Mental disorders; Mentorship; Methodology; Methods; Modeling; Morbidity - disease rate; National Institute of Mental Health; Outcome; Parents; Patient Self-Report; Personality; Phenotype; Population; Positive Valence; Prefrontal Cortex; Process; Prognosis; Psychopathology; Regulation; Research; Rewards; Risk; Risk Marker; Role; School-Age Population; Social Functioning; Stimulus; Strategic Planning; Symptoms; System; Temperament; Time; Training; Ventral Striatum; brain behavior; clinical diagnosis; developmental psychology; emotion dysregulation; emotion regulation; emotional functioning; emotional stimulus; functional MRI scan; functional disability; improved; longitudinal analysis; longitudinal design; negative affect; negative mood; neural; neural correlate; pleasure; psychiatric symptom; resilience; response; study population; symptomatology

PROJECT SUMMARY Emotion dysregulation is transdiagnostic, integral to most affective and disruptive behavior disorders, and is associated with impaired functioning across domains from health to academics. The study of dysregulation of negative affect, or irritability, has resulted in a better understanding of how it predicts later impairment and general psychopathology and has identified neural correlates. However, there has been less focus on dysregulation of positive affect, despite recent evidence suggesting it contributes to the development of psychopathology, particularly externalizing symptoms, and impairment across domains from general to social functioning. Dysregulated positive affect may not only confer independent risk, but is likely to have separate underlying neural correlates, as positive and negative emotional valence systems are different domains in the Research Domains Criteria. While surgency, the temperamental measure of high positive affect, has been related to increased aggression and externalizing symptoms in infants and young children, how this relates to clinical dysregulation of positive affect, or excitability, is unknown. Moreover, the relationships between surgency and excitability with psychopathology and impairment have been largely unstudied in young children. This proposal addresses these gaps in understanding by studying the overlapping and separable contributions of surgency (normative high positive affect), excitability (clinically related dysregulated positive affect), and irritability (clinically related dysregulated negative affect) to symptoms of psychopathology and impairment in school age children. Additionally, this proposal will assess the overlap and distinctions in brain-behavior relationships between dysregulation in positive and negative affect. Specifically, 100 7-10-year-old children enriched for emotion dysregulation will be assessed using a research diagnostic interview and parent and self- report measures of emotional and general functioning at baseline and after one year. At baseline, children will undergo functional MRI scans during emotion response and regulation tasks. Consistent with the NIMH Strategic plan, particularly Strategy Objective 2, to “chart mental illness trajectories to determine when, where, and how to intervene,” understanding the separable contributions of surgency, excitability, and irritability to risk trajectories and elucidating the neural correlates of such can provide meaningful targets for early identification and intervention in multiple disorders. Under the mentorship of a diverse team of experts in emotion regulation and development, developmental psychology and psychopathology, and longitudinal and statistical methodology, the training provided through this proposal will facilitate the applicant gaining expertise in fMRI methods for studying affective processing, dimensional constructs in developmental psychopathology, and longitudinal design and analysis. This training will provide the foundational components of the applicant's long-term goals of understanding the neural and behavioral development of emotion dysregulation, specifically excitability, to inform early identification and interventions for improving emotion regulation prior to significant impairment.

项目摘要 情绪失调是经诊断的，是大多数情感和破坏性行为障碍不可或缺的，并且是 与从健康到学者的跨领域的功能受损相关。失调的研究 负面影响或易怒，使人们更好地了解了它如何预测后来的障碍和 一般的心理病理学并确定了神经相关性。但是，对 积极影响的失调，最近的证据表明它有助于发展 心理病理学，特别是外在症状以及从一般到社会领域的损害 功能。失调的积极影响不仅可能赋予独立风险，而且可能具有独立的风险 潜在的神经相关性，因为积极和负面的情绪价系统是不同的领域 研究领域标准。虽然外科手术，但高积极影响的温度测量已经 与婴儿和幼儿的侵略性增加和外在症状有关，这与 积极影响或兴奋性的临床失调尚不清楚。而且，手术之间的关系 幼儿对精神病理学和障碍的激动人心在很大程度上没有被研究。这 提案通过研究的理解差距来解决这些差距。 手术（规范性的高积极影响），令人兴奋的（临床相关的积极影响）和 对精神病理学症状和障碍症状的易怒（临床相关的负面影响） 学龄儿童。此外，该提案将评估脑行为的重叠和区分 积极和负面影响失调之间的关系。具体来说，有100个7-10岁的孩子 将使用研究诊断访谈和父母和自我评估的情绪失调。 报告基线和一年后的情绪和一般功能的度量。在基线时，孩子将 在情绪响应和调节任务中，进行功能性MRI扫描。与NIMH战略一致 计划，特别是策略目标2，以“绘制精神疾病轨迹，以确定何时，何地以及如何 干预，“了解手术，兴奋和易怒的风险轨迹的单独贡献 并阐明这种神经相关性可以为早期识别和 干预多种疾病。在情绪监管专家的潜水团队的心态下 发展，发育心理学和心理病理学以及纵向和统计方法论， 通过此建议提供的培训将有助于申请人获得fMRI方法的专业知识 情感处理，发展心理病理学中的维度结构以及纵向设计和 分析。该培训将为申请人的长期目标提供基础组成部分 了解情绪失调的神经和行为发展，特别是令人兴奋，以告知 早期识别和干预措施，以改善严重损害之前的情绪调节。