Hormones: Molecular Mechanism of Action and Functions

激素：作用和功能的分子机制

• 批准号: 10207070
• 负责人: STAVROULA KOUSTENI
• 金额: $ 21.56万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10207070
• 关键词: Hormones; Molecular Mechanisms of Action

Project Summary/Abstract The long standing goals of this training grant are to provide support and training to academically strong and highly motivated predoctoral and postdoctoral researchers in the field of endocrinology and related subjects dealing with all aspects of hormone biology at the organ, cellular, molecular levels through modern genetic tools in various model organisms. We aim to provide our trainees with a broad intellectual background that includes coursework, experimental expertise, seminars, grant craftsmanship and career advice. The program is implemented by our outstanding training faculty and the rich research infrastructure at Columbia University. The training faculty are highly collaborative and national and international leaders in research exploring the mechanisms of steroid, retinoid, thyroid and polypeptide hormones as well as the paracrine interactions associated with growth factors, cytokines and important signaling transduction pathways and inter-organ communications. The trainees can work in diverse experimental systems across model organisms and human subjects. We continually update our training faculty to reflect the evolving trends in research in endocrinology and the changing Columbia faculty base. This training program has been in effect for 42 years and the accomplishments of our trainees during this time have been outstanding, with many of them currently holding NIH funded tenure track faculty positions in premier academic institutions. During the past cycle (2015-2019), A total of 19 unique trainees have been supported or are currently being supported by the training grant. The recently funded trainees have all been extremely productive in their research programs. All previous trainees continue to pursue science related careers. Most of our postdoctoral fellows have attained individual research grants. We continue to work with our fellows to help them achieve success in their current and future research careers. Overall, the training program emphasizes excellence in scholarship and research and career advising. In addition, participation in the program exposes trainees from diverse disciplines to practical applications in endocrinology and highlights translational aspects of their research. Due to the steadily increasing demand for training grant slots, we are requesting additional positions to accommodate our highly qualified pool of applicants.

项目摘要/摘要 这项培训补助金的长期目标是为学术上的强大提供支持和培训 内分泌和相关学科领域的高度积极性前者和博士后研究人员 通过现代遗传来处理器官，细胞，分子水平的激素生物学的各个方面 各种模型生物的工具。我们旨在为学员提供广泛的知识背景 包括课程工作，实验专业知识，研讨会，赠款工艺和职业建议。该程序 由我们杰出的培训学院和哥伦比亚大学丰富的研究基础设施实施。 培训学院是高度合作和国家和国际领导者，探索了 类固醇，视视感素，甲状腺和多肽激素以及旁分泌相互作用的机制 与生长因子，细胞因子和重要信号转导途径和器官间相关 通讯。学员可以在模型生物和人类的各种实验系统中工作 主题。我们不断更新培训教师，以反映内分泌研究研究的不断发展的趋势 以及不断变化的哥伦比亚教职员工。该培训计划已有42年了， 在此期间，我们的学员的成就非常出色，其中许多目前都有 NIH资助了总理学术机构的任期教师职位。在过去的周期（2015- 2019年）中， 总共有19名独特的学员得到了支持或目前得到培训补助金的支持。这 最近资助的学员在其研究计划中都非常有生产力。所有以前的学员 继续从事与科学有关的职业。我们的大多数博士后研究员都获得了个人研究 赠款。我们继续与研究员合作，以帮助他们在当前和未来的研究中取得成功 职业。总体而言，培训计划强调了奖学金，研究和职业的卓越 建议。此外，参与该计划还使学员从各种学科接触到实践 内分泌学中的应用并突出了其研究的翻译方面。由于稳定 对培训赠款老虎机的需求不断增加，我们要求其他职位以适应我们的高度 合格的申请人池。