Sources, Transport, Exposure and Effects of PFASs (STEEP)

PFAS 的来源、传输、暴露和影响 (STEEP)

• 批准号: 10205263
• 负责人: Rainer Lohmann
• 金额: $ 1.08万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205263
• 关键词: Address; Advisory Committees; Affect; Animals; Awareness; Benchmarking; Binding; Biological Availability; Biota; Blood; Characteristics; Cods; Communication; Communication Tools; Communities; Complex; Decision Making; Dependence; Detection; Development; Dose; Ensure; Environment; Environmental Engineering technology; Environmental Health; Environmental Pollution; Epidemiology; Exposure to; Film; Fingerprint; Fishes; Food Webs; Functional disorder; Government Agencies; Health; Human; Human Milk; Immune System Diseases; In Situ; Individual; Industrialization; Institutes; Internships; Intervention; Joints; Laboratories; Life; Link; Measurement; Metabolic; Methodology; Modeling; Molecular; Oils; Organ; Outcome; Pathway interactions; Plant Roots; Poly-fluoroalkyl substances; Population; Prevention; Process; Property; Proteins; Public Health; Publishing; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Risk; Rodent Model; Sampling; Science; Scientist; Site; Source; Study models; Superfund; Techniques; Time; Toxicology; Training; Translating; Translational Research; Uncertainty; Universities; Water; aqueous; base; community organizations; consumer product; contaminated drinking water; drinking water; early life exposure; environmental chemistry; epidemiology study; experimental study; exposed human population; exposure pathway; food chain contamination; ground water; improved; in utero; innovation; insight; next generation; novel; postnatal; practical application; program dissemination; programs; receptor; remediation; research and development; skills; tool; uptake

PROJECT SUMMARY/ABSTRACT The URI-led STEEP (Sources, Transport, Exposure and Effects of PFASs) proposes to aid the Superfund Research Program in addressing the emerging and expanding problem of poly- and perfluorinated alkyl substances (PFASs) contamination. PFASs are industrial compounds that have been manufactured since the 1950s for use in a myriad of products due to their unique oil and water repellent properties. The environmental dissemination and the human health effects of PFASs are only beginning to emerge. Thus, the U.S. EPA limits for PFAS contamination of drinking water remain provisional since they were first published in 2009. In the recently released 2015 draft ToxProfile, ATSDR highlighted uncertainties and disregarded recent reports on adverse human health effects of PFAS exposures from epidemiological studies. Thus, the need for improved risk characterization is urgent and timely. STEEP aims to better understand the pathways of PFAS contamination from entry into the environment through groundwater contamination, dispersal through the food web, and distribution to vulnerable human populations during early development, in part through breast milk. Specifically, STEEP will characterize sources of PFAS through in situ groundwater measurements combined with geochemical modeling to assess transport and fate (Project 1). The biomedical studies will assess the relationship of PFAS to risk of immune dysfunction and metabolic abnormalities, to be used to derive benchmark doses levels for PFASs for improved risk characterization. Due to the hypersusceptibility during early development, the research will focus on the impact of in utero and early postnatal PFAS exposures on sensitive indicators of organ dysfunctions through parallel human epidemiologic studies (Project 2) and rodent model studies (Project 3). Then, environmental engineering and chemistry research will support the development and deployment of in situ passive sampling techniques for PFAS and their precursors in water (Project 4). STEEP will thereby address limitations in the current understanding of human exposure to PFAS by combining targeted human exposure assessment with chemometric approaches to characterize existing PFAS sources. To ensure a legacy of scientific awareness, the dissemination of broadly accessible research findings, and practical application by affected communities, STEEP Cores will match the intensity and rigor of the research projects. STEEP Cores will serve to a) prepare the next generation of interdisciplinary emerging contaminant researchers (Training Core), b) translate scientific findings generated by STEEP projects for dissemination to various internal and external stakeholders (Research Translation Core), and c) engage Cape Cod communities on the front lines of PFASs exposure through drinking water contaminated by Aqueous film forming foam use at Joint Base Cape Cod. The Administrative Core, led by its directors, and guided by Internal and External Advisory Committees, will ensure the integration of STEEP’s projects and cores.

项目摘要/摘要 尿液领导的陡峭（PFASS的传输，运输，暴露和影响）提案，以帮助超级基金 解决多氟烷基的新兴和扩展问题的研究计划 物质（PFASS）污染。 PFAS是自从 1950年代由于其独特的油和驱动物质而用于无数产品。环境 PFAS的传播和人类健康影响才刚刚开始出现。那是美国EPA的限制 自从2009年首次出版以来，饮用水的污染仍然是临时的。 ATSDR最近发布了2015年的2015年Toxprofile草案，强调了不确定性，无视最近的报告 流行病学研究中PFA暴露的不良人类健康影响。那，需要改善 风险表征是紧迫而及时的。 陡峭的目标是更好地了解从进入环境的PFA污染的途径 通过地下水污染，通过食物网散布并分配给脆弱的人 早期发育过程中的种群部分通过母乳。具体而言，陡峭的特征是 PFA通过原位地下水测量结果与地球化学建模相结合以评估 运输与命运（项目1）。生物医学研究将评估PFA与免疫风险的关系 功能障碍和代谢异常，用于得出PFASS的基准剂量水平以改进 风险表征。由于早期发展过程中的过度概念能力，研究将重点放在 在子宫和早期产后PFA暴露对通过器官功能障碍的敏感指标的影响 平行人类流行病学研究（项目2）和啮齿动物模型研究（项目3）。然后，环境 工程和化学研究将支持原位被动抽样的开发和部署 PFA及其在水中的前体的技术（项目4）。陡峭的陡峭将解决限制 通过将针对目标的人类暴露评估与 化学计量方法以表征现有的PFA源。 为了确保科学意识的遗产，传播广泛可访问的研究结果， 以及受影响社区的实际应用，陡峭的岩心将与 研究项目。陡峭的核心将用于a）准备下一代跨学科的新兴 污染研究人员（培训核心），b）翻译由陡峭项目产生的科学发现 传播到各种内部和外部利益相关者（研究翻译核心），c）参与斗篷 PFAS的前线鳕鱼社区通过饮用水暴露于水性膜污染的饮用水 在联合基本角鳕鱼中形成泡沫使用。由其董事领导的行政核心，并在内部的指导下进行 和外部咨询委员会将确保陡峭的项目和核心的整合。