Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL

来源、运输、暴露

• 批准号: 10704006
• 负责人: Rainer Lohmann
• 金额: $ 153.43万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704006
• 关键词: Accounting; Address; Adverse effects; Affect; Air; Area; Atmosphere; Awareness; Biological Markers; Breast Feeding; Chemicals; Child; Cods; Collaborations; Communication; Communication Tools; Communities; Complex; Coronavirus; Data; Data Analyses; Delaware; Dependence; Detection; Development; Diffuse; Dust; Education; Endocrine; Endocrine disruption; Environmental Engineering technology; Environmental Science; Excretory function; Exposure to; FAIR principles; Faeroe Islands; Feedback; Film; Fishes; Food; Fostering; Funding; Goals; Great Lakes Region; Growth; Health; Human; Human Milk; Immunologic Markers; Infant; Intervention; Joints; Knowledge; Laboratories; Link; Measurement; Measures; Mentors; Mentorship; Metabolic; Metabolism; Milk; Modeling; Molecular; Outcome; Paper; Pathway interactions; Policies; Prevention strategy; Privatization; Process; Public Health; Research; Research Project Grants; Resources; Rhode Island; Risk; Risk Assessment; Rodent; Safety; Science; Serum; Shellfish; Signal Recognition Particle; Site; Soil; Source; Superfund; Time; Tissues; Toxicokinetics; Training; Translating; Translational Research; Tribes; Uncertainty; United States National Institutes of Health; Universities; Vaccination; Vulnerable Populations; Wampanoag; Water; Work; absorption; age related; analytical tool; aqueous; base; bioaccumulation; cohesion; cohort; community engagement; data management; drinking water; effectiveness evaluation; environmental chemistry; equity, diversity, and inclusion; experience; exposed human population; exposure pathway; ground water; high school; immunotoxicity; improved; indoor air; innovation; insight; novel; outreach; oxidation; pollutant; predictive modeling; prevent; programs; remediation; response; superfund site; tool; uptake

PROJECT SUMMARY/ABSTRACT – OVERALL PFAS have emerged as national priority pollutants, and more than 2000 sites contaminated by PFAS have been identified across the U.S., including 180 EPA-identified Superfund sites. Elevated human exposures to PFAS have been associated with adverse health outcomes, including metabolic disruption, immunotoxicity, and endocrine disruption, although exposure-dependence and individual vulnerability need to be better understood. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement and outreach in support of SRP mandates. STEEP II will continue to collaborate with the RI and MA state and federal agencies, and will expand its reach to work with DE, ME, NJ, and MI state agencies in support of their needs for knowledge on PFAS. The environmental engineering and chemistry projects will focus on the transport and transformation of PFAS precursors, as well as legacy, novel, and total PFAS. Novel detection tools will be developed and used to support remediation of PFAS- contaminated groundwater, the atmospheric transport and fate of PFAS, and to predict bioaccumulation of PFAS relative to modeling predictions. The Center will build on its leading research on the critical effects of PFAS in children, with a focus on immunotoxicity and metabolism. Given the public health importance of breastfeeding, STEEP II will focus on understanding cellular mechanisms that dictate PFAS uptake and elimination into milk and accumulation in the infant, thereby advancing understanding of toxicokinetic mechanisms and potentials for preventing PFAS from reaching human milk. STEEP II research projects, working with the Community Engagement Core (CEC) and the Data Management and Analysis Core (DMAC), will perform a thorough human exposure assessment for PFAS and risk assessment. STEEP trainees and mentors will remain key to the ongoing growth as a unified Center, via cross-cutting collaboration fostered by the Research Experience and Training Coordination Core (RETCC), and joint mentorship. STEEP II will include an additional focus on Diversity, Equity, and Inclusion (DEI) training for trainees and mentors alike. The STEEP II goals will address the following Specific Aims: Specific Aim 1: Assess the distribution, transformations, and bioaccumulation of PFAS Specific Aim 2: Investigate the processes affecting PFAS distribution and uptake and assess critical adverse effects in humans Specific Aim 3: Engage new and established stakeholders across multiple sites Specific Aim 4: Integrate STEEP internally and execute effective outreach and collaboration with stakeholders

项目摘要/摘要 - 总体 PFA已成为国家优先污染物，2000多个受PFA污染的地点已经存在 在美国各地确定，包括180个EPA识别的超级基金网站。人类对PFA的暴露率高 与不良健康结果有关，包括代谢中断，免疫毒性和 尽管需要更好地理解暴露依赖性和个人脆弱性，但内分泌干扰仍需要更好地理解。 陡峭的II建立在它在第一个陡峭的SRP中心（陡峭I）中建立的成功合作基础上 进一步推进了支持SRP任务的科学，培训，参与和宣传。陡峭的II 继续与RI和MA州和联邦机构合作，并将扩大其与DE合作的影响力 我，新泽西州和MI州机构支持他们对PFA的知识需求。环境工程 化学项目将着重于PFA的前体的运输和转型，以及遗产， 小说和全部PFA。新型检测工具将被开发并用于支持PFAS-的补救 受污染的地下水，PFA的大气传输和命运，并预测PFA的生物蓄积 相对于建模预测。该中心将基于对PFA在PFA中的关键影响的主要研究基础 儿童，专注于免疫毒性和代谢。考虑到公共健康的母乳喂养重要性， 陡峭的II将专注于理解决定PFA摄取和消除牛奶的细胞机制 并在婴儿中积累，从而促进对毒物机制和潜力的理解 防止PFA到达人奶。陡峭的II研究项目，与社区合作 参与核心（CEC）和数据管理和分析核心（DMAC）将进行彻底的人类 PFA和风险评估的暴露评估。陡峭的学员和导师将仍然是 作为一个统一中心的持续增长，通过研究经验培养的横切协作和 培训协调核心（RETCC）和联合心态。陡峭的II将包括对多样性的额外关注， 对学员和导师的公平和包容（DEI）培训。陡峭的II目标将解决以下 具体目的： 特定目的1：评估PFA的分布，转换和生物积累 特定目的2：调查影响PFA分布以及摄取和评估关键的过程 人类的不利影响 特定目的3：与多个站点的新利益相关者互动 特定目标4：内部陡峭的陡峭并执行有效的外展和合作 利益相关者