Routing of SPW-R content via distinct hippocampal output pathways

通过不同的海马输出途径进行 SPW-R 内容的路由

基本信息

批准号：
10202754
负责人：
MARK J SCHNITZER
金额：
$ 44.13万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10202754
关键词：
Affect Anatomy Behavior Behavioral Calcium Crystallization Dependence Dorsal Electrophysiology (science)Emotional Equine mule Event Head Heterogeneity Hippocampus (Brain)Image Label Learning Location Mediating Memory Microscope Microscopic Morphology Mus Neurons Opsin Output Pathway interactions Pattern Performance Population Preparation Pyramidal Cells Radial Resolution Route Silicon Techniques Viral Virus cranium experimental study fluorophore inhibitory neuron insight memory consolidation neocortical novel optogenetics postsynaptic presynaptic recruit segregation transmission process voltage

Affect Anatomy Behavior Behavioral Calcium Crystallization Dependence Dorsal Electrophysiology (science)Emotional Equine mule Event Head Heterogeneity Hippocampus (Brain)Image Label Learning Location Mediating Memory Microscope Microscopic Morphology Mus Neurons Opsin Output Pathway interactions Pattern Performance Population Preparation Pyramidal Cells Radial Resolution Route Silicon Techniques Viral Virus cranium experimental study fluorophore inhibitory neuron insight memory consolidation neocortical novel optogenetics postsynaptic presynaptic recruit segregation transmission process voltage

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项目摘要

As synchronous population events SPW-Rs are strongly implicated in the transmission of intra- hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells (CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent studies demonstrated the presence of a large degree of morphological and functional heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the presence of target-specific functional subdivisions within the hippocampal network. However, the precise anatomical and functional organization, recruitment mechanisms and behavioral relevance of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project 4, we will perform an extensive set of new correlational and pertubational experiments which will provide novel insights into CA1PC target-specific SPW-R organization and function.

由于同步人口事件SPW-RS与内部的传播非常重要海马储存的表示向外海马目标的表示，支持合并这些目标的内存。主要海马输出源自CA1锥体细胞（CA1PC）和具有特定皮质和皮质下海马靶标的CA1PC是被认为是沿主要海马解剖轴差异分布的。反过来，最近研究表明存在很大程度的形态和功能 CA1PC种群内的异质性沿着这些相同的海马轴，表明海马网络中存在目标特异性功能细分。但是，精确的解剖和功能组织，招聘机制和行为相关性这些沿这些海马外靶标特异性细分沿SPW-RS的SPW-RS仍然未知。在项目中 4，我们将执行一系列新的相关和垂直实验，将向CA1PC特定的SPW-R组织和功能提供新的见解。