Routing of SPW-R content via distinct hippocampal output pathways

通过不同的海马输出途径进行 SPW-R 内容的路由

• 批准号: 10202754
• 负责人: MARK J SCHNITZER
• 金额: $ 44.13万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202754
• 关键词: Affect; Anatomy; Behavior; Behavioral; Calcium; Crystallization; Dependence; Dorsal; Electrophysiology (science); Emotional; Equine mule; Event; Head; Heterogeneity; Hippocampus (Brain); Image; Label; Learning; Location; Mediating; Memory; Microscope; Microscopic; Morphology; Mus; Neurons; Opsin; Output; Pathway interactions; Pattern; Performance; Population; Preparation; Pyramidal Cells; Radial; Resolution; Route; Silicon; Techniques; Viral; Virus; cranium; experimental study; fluorophore; inhibitory neuron; insight; memory consolidation; neocortical; novel; optogenetics; postsynaptic; presynaptic; recruit; segregation; transmission process; voltage

As synchronous population events SPW-Rs are strongly implicated in the transmission of intra- hippocampally stored representations to extra-hippocampal targets, supporting the consolidation of memory at these targets. The primary hippocampal output originates from CA1 pyramidal cells (CA1PCs), and CA1PCs with specific cortical and subcortical extra-hippocampal targets are thought to be differentially distributed along the main hippocampal anatomical axes. In turn, recent studies demonstrated the presence of a large degree of morphological and functional heterogeneity within the CA1PC populations along these same hippocampal axes, suggesting the presence of target-specific functional subdivisions within the hippocampal network. However, the precise anatomical and functional organization, recruitment mechanisms and behavioral relevance of SPW-Rs along these extra-hippocampal target-specific subdivisions remain unknown. In Project 4, we will perform an extensive set of new correlational and pertubational experiments which will provide novel insights into CA1PC target-specific SPW-R organization and function.

作为同步群体事件，SPW-R 与内部传播密切相关。 海马存储对海马外目标的表征，支持整合 这些目标的记忆。初级海马输出源自 CA1 锥体细胞 (CA1PCs)，以及具有特定皮质和皮质下海马外目标的 CA1PCs 据认为沿主要海马解剖轴有差异性分布。反过来，最近 研究表明存在很大程度的形态和功能 CA1PC 群体内沿这些相同海马轴的异质性，表明 海马网络内存在特定目标的功能细分。然而， 精确的解剖和功能组织、招募机制和行为相关性 SPW-R 沿着这些海马外目标特异性细分的情况仍然未知。项目中 4，我们将进行一组广泛的新的相关和微扰实验，这将 为 CA1PC 目标特定 SPW-R 组织和功能提供新颖的见解。