Clinical Research Design, Epidemiology and Biostatistics Core

临床研究设计、流行病学和生物统计学核心

• 批准号: 10201620
• 负责人: William Johnson
• 金额: $ 36.1万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201620
• 关键词: Address; Alabama; Applications Grants; Attention; Award; Bioinformatics; Biometry; Biostatistics Core; Center for Translational Science Activities; Centers of Research Excellence; Clinical; Clinical Research; Clinical Sciences; Consultations; Data Analyses; Development; Ensure; Environment; Epidemiologist; Epidemiology; Faculty; Funding; Goals; Grant; Informatics; Infrastructure; Institution; Leadership; Louisiana; Manuscripts; Modeling; Molecular Epidemiology; Observational Study; Peer Review; Pilot Projects; Preparation; Publications; Publishing; Reproducibility; Research; Research Design; Research Personnel; Resource Sharing; Resources; Scientist; Services; Statistical Methods; Translational Research; Universities; Work; biomedical informatics; clinical center; cohort; data mining; design; epidemiology study; experimental study; innovation; member; multidisciplinary; novel; precision medicine; programs; support network; working group

PROJECT SUMMARY: DESIGN, EPIDEMIOLOGY, AND BIOSTATISTICS CORE The overall goal of the Clinical Research Design, Epidemiology, and Biostatistics Key Component Activity (DEB KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to ensure that all clinical and translational research conducted within the LA CaTS purview meets the highest scientific standards for study design and analysis. During the initial funding period, we successfully leveraged existing DEB expertise from the faculties of the Primary Collaborating Institutions and implemented an integrated DEB support network that is now available to investigators at all participating LA CaTS institutions. We now provide DEB services and consultation to COBRE/INBRE mentees across the state, to our Roadmap and Meritorious scholars, and to other investigators seeking to expand their research toward translational efforts. To meet the needs for additional bioinformatics expertise, the DEB KCA director led the creation of the Southeast Informatics Consortium (SIC) to identify specific requirements, formulate ways to share resources and work together to advance the use of bioinformatics in clinical and translational research. The LA CATS leadership, and their respective institutions, provided considerable resources enabling the DEB KCA to expand our biostatistics capacity, add additional epidemiology expertise, and provide unique proficiency in bioinformatics approaches. We are a comprehensive DEB resource for LA CaTS investigators and we offer one of the most requested services within the LA CaTS Center. Aim 1. Enhance and expand the DEB KCA by developing and implementing strategic study designs, emphasizing rigor, reproducibility, validity, and sustainability of our findings. This will be accomplished using appropriate controls and comparison conditions, reducing bias, and increasing study power efficiency followed by deploying state-of-the-art data analyses, objective and transparent interpretation of research findings, publishing new discoveries, and seeking funding to support the next steps in our research pursuits. Aim 2. Create and implement novel statistical analytics, inferential and modeling solutions in data mining, precision medicine and molecular epidemiology in addition to more traditional experimental and observational research with strong emphasis on special Louisiana cohorts. Aim 3. Promote and deliver professional development by providing educational opportunities for faculty, trainees, and research staff. Thus, the DEB KCA strives to justify clinical and translational research conclusions through rigorous pursuit and objective interpretation of investigative findings within a well-established infrastructure for arriving at sustainable inferential conclusions.

项目摘要：设计，流行病学和生物统计学核心 临床研究设计，流行病学和生物统计学关键组成部分的总体目标 路易斯安那州临床和转化科学中心（LA CATS）的活动（DEB KCA）是确保所有人 LA CATS PURVIEW内进行的临床和翻译研究符合最高的科学 研究设计和分析标准。在最初的资金期间，我们成功利用了现有 主要合作机构学院的DEB专业知识，并实施了综合的DEB 现在，所有参与的洛杉矶猫机构的调查人员都可以使用支持网络。我们现在提供 DEB服务和咨询全州的Cobre/Inbre受训者，我们的路线图和合理性 学者以及其他寻求将研究扩大到翻译工作的研究人员。见面 DEB KCA董事的需求需要其他生物信息学专业知识，领导了东南部的创建 信息协会（SIC）确定特定要求，制定分享资源和工作的方法 共同提高生物信息学在临床和转化研究中的使用。洛杉矶猫的领导， 以及他们各自的机构提供了可观的资源，使Deb KCA能够扩展我们 生物统计学能力，增加其他流行病学专业知识，并提供独特的生物信息学熟练程度 方法。我们是La Cats调查人员的全面DEB资源，我们提供最多的DEB资源 在洛杉矶猫中心要求的服务。目标1。通过开发和扩展DEB KCA和扩展 实施战略研究设计，强调我们的严格，可重复性，有效性和可持续性 发现。这将使用适当的控件和比较条件，减少偏差和 提高研究功率效率，然后部署最先进的数据分析，目标和 对研究结果的透明解释，发布新发现以及寻求资金来支持 我们的研究追求的下一步。目标2。创建和实施新颖的统计分析，推理和 除了更多 传统的实验和观察性研究，非常重视特殊的路易斯安那州队列。目标3。 通过为教师，学员和 研究人员。因此，DEB KCA致力于通过 严格的追求和客观解释调查结果在建立良好的基础设施中 得出可持续的推论结论。