Clinical Research Design, Epidemiology and Biostatistics Core

临床研究设计、流行病学和生物统计学核心

• 批准号: 9361811
• 负责人: William Johnson
• 金额: $ 36.36万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9361811
• 关键词: Address; Alabama; Applications Grants; Attention; Award; Bioinformatics; Biometry; Biostatistics Core; Center for Translational Science Activities; Centers of Research Excellence; Clinical; Clinical Research; Clinical Sciences; Consultations; Data Analyses; Development; Ensure; Environment; Epidemiologist; Epidemiology; Faculty; Funding; Goals; Grant; Informatics; Institution; Leadership; Louisiana; Manuscripts; Modeling; Molecular Epidemiology; Observational Study; Peer Review; Pilot Projects; Preparation; Publications; Publishing; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Scientist; Services; Statistical Methods; Translational Research; Universities; Work; biomedical informatics; cohort; data mining; design; epidemiology study; experimental study; innovation; member; multidisciplinary; novel; precision medicine; programs; support network; working group

PROJECT SUMMARY: DESIGN, EPIDEMIOLOGY, AND BIOSTATISTICS CORE The overall goal of the Clinical Research Design, Epidemiology, and Biostatistics Key Component Activity (DEB KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to ensure that all clinical and translational research conducted within the LA CaTS purview meets the highest scientific standards for study design and analysis. During the initial funding period, we successfully leveraged existing DEB expertise from the faculties of the Primary Collaborating Institutions and implemented an integrated DEB support network that is now available to investigators at all participating LA CaTS institutions. We now provide DEB services and consultation to COBRE/INBRE mentees across the state, to our Roadmap and Meritorious scholars, and to other investigators seeking to expand their research toward translational efforts. To meet the needs for additional bioinformatics expertise, the DEB KCA director led the creation of the Southeast Informatics Consortium (SIC) to identify specific requirements, formulate ways to share resources and work together to advance the use of bioinformatics in clinical and translational research. The LA CATS leadership, and their respective institutions, provided considerable resources enabling the DEB KCA to expand our biostatistics capacity, add additional epidemiology expertise, and provide unique proficiency in bioinformatics approaches. We are a comprehensive DEB resource for LA CaTS investigators and we offer one of the most requested services within the LA CaTS Center. Aim 1. Enhance and expand the DEB KCA by developing and implementing strategic study designs, emphasizing rigor, reproducibility, validity, and sustainability of our findings. This will be accomplished using appropriate controls and comparison conditions, reducing bias, and increasing study power efficiency followed by deploying state-of-the-art data analyses, objective and transparent interpretation of research findings, publishing new discoveries, and seeking funding to support the next steps in our research pursuits. Aim 2. Create and implement novel statistical analytics, inferential and modeling solutions in data mining, precision medicine and molecular epidemiology in addition to more traditional experimental and observational research with strong emphasis on special Louisiana cohorts. Aim 3. Promote and deliver professional development by providing educational opportunities for faculty, trainees, and research staff. Thus, the DEB KCA strives to justify clinical and translational research conclusions through rigorous pursuit and objective interpretation of investigative findings within a well-established infrastructure for arriving at sustainable inferential conclusions.

项目摘要：设计、流行病学和生物统计学核心 临床研究设计、流行病学和生物统计学关键组成部分的总体目标 路易斯安那州临床和转化科学中心 (LA CaTS) 的活动 (DEB KCA) 旨在确保所有 LA CatS 权限内进行的临床和转化研究符合最高科学标准 研究设计和分析的标准。在最初的融资期间，我们成功地利用了现有的资金 来自主要合作机构院系的 DEB 专业知识并实施了综合 DEB 现在，所有参与 LA CatS 机构的调查人员都可以使用该支持网络。我们现在提供 DEB 为全州 COBRE/INBRE 学员提供服务和咨询，了解我们的路线图和 Meritorious 学者以及其他寻求将研究扩展到转化工作的研究人员。为了满足 由于需要额外的生物信息学专业知识，DEB KCA 主任领导创建了东南部 信息学联盟（SIC）确定具体要求，制定共享资源和工作的方法 共同推进生物信息学在临床和转化研究中的应用。 LA CATS 的领导层， 及其各自的机构，提供了大量资源，使 DEB KCA 能够扩大我们的 生物统计学能力，增加额外的流行病学专业知识，并提供生物信息学方面的独特熟练程度 接近。我们是 LA CatTS 调查人员的综合 DEB 资源，我们提供最全面的 DEB 资源之一 在 LA CatTS 中心内请求服务。目标 1. 通过开发和扩展 DEB KCA 实施战略研究设计，强调我们的研究的严谨性、可重复性、有效性和可持续性 发现。这将通过使用适当的控制和比较条件来实现，减少偏差，并 提高研究效率，然后部署最先进的数据分析、客观和 透明地解释研究结果，发布新发现，并寻求资金支持 我们研究的下一步。目标 2. 创建并实施新颖的统计分析、推理和 数据挖掘、精准医学和分子流行病学等领域的建模解决方案 传统的实验和观察研究，重点关注特殊的路易斯安那群体。目标3。 通过为教师、学员和学生提供教育机会来促进和实现专业发展 研究人员。因此，DEB KCA 致力于通过以下方式证明临床和转化研究结论的合理性： 在完善的基础设施内对调查结果进行严格的追求和客观的解释 得出可持续的推理结论。