Research Training in Pediatric Non-Malignant Hematology

儿科非恶性血液学研究培训

• 批准号: 10201726
• 负责人: Clinton H Joiner
• 金额: $ 24.79万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201726
• 关键词: Childhood; Hematology; Non-Malignant; Research Training

This new T32 training grant addresses the crucial need for programs to train physician scientists and clinical investigators in pediatric non-malignant hematology. Research in hematology – particularly in pediatrics – has elucidated many of the genetic, cellular and molecular mechanisms underlying disease processes, as well as fundamental cellular functions such as cell differentiation and gene regulation. Yet despite the many scientific and clinical advances in hematology over the past decades, the number of investigators funded by NIH for hematology related research has steadily declined since 2002. The Hematology Training Program (HTP) supported by this T32 will offer rigorous training in basic/translational research to postdoctoral MD, MD/PhD and PhD fellows, under the mentorship of 28 faculty mentors supported by $25.7 M in extramural funding ($17.3 from Federal sources). At Emory University, established research programs in sickle cell disease, hemostasis and thrombosis, hematopoiesis and stem cell biology, gene therapy, and red cell physiology and transfusion medicine are embedded in the largest clinical program in pediatric hematology in the country, providing huge patient volumes for clinical and translational research within Children's Healthcare of Atlanta. Partnerships with the Georgia Institute of Technology and Morehouse School of Medicine broaden the faculty mentor pool. Each trainee will have a laboratory research Mentor and a clinical Co-mentor to foster basic or translational research relevant to pediatric hematology. Pairing of senior mentors with junior mentors from a pool of 11 young faculty members will expand the supply of future mentors. Integrated into the highly successful Pediatric Hematology/Oncology/Bone Marrow Transplant (BMT) Fellowship Program of the Aflac Cancer and Blood Disorders Center, the new HTP will admit 2 fellows each year for 2 years of support, training 5-7 MD fellows and 3-5 PhD postdoctoral fellows over 5 years. Candidates will be MD, MD/PhD and PhD fellows within the Fellowship Training Program and associated laboratories, as well as external candidates chosen on the basis of their prior training and research accomplishments, academic potential, and commitment to research in non-malignant hematology. In addition to rigorous laboratory research training, trainees will participate in a course in conduct of ethical research, departmental career development seminars, grant writing and academic skills training, research conferences, journal clubs, and fellowship program research retreats. Individual Training Plans will be developed for each trainee and progress will be monitored by a multidisciplinary scholarship oversight committees. Trainees will present their work at national meetings and develop applications for career development (K-type) awards. The HTP will take advantage of the extensive research resources of Emory University, including formal course work and degree programs in clinical and translational research available through Emory's CTSA program. Establishment of this program will allow us to train the next generation of academic leaders in pediatric non-malignant hematology.

这项新的 T32 培训补助金满足了培训医师科学家和临床人员的计划的迫切需求 儿科非恶性血液学研究人员——特别是儿科—— 阐明了疾病过程中的许多遗传、细胞和分子机制，以及 尽管有很多基本的细胞功能，例如细胞分化和基因调控。 过去几十年来血液学领域的科学和临床进展，由资助的研究人员数量 自 2002 年以来，NIH 的血液学相关研究一直在稳步下降。血液学培训计划 (HTP) 在此 T32 的支持下将为博士后 MD 提供严格的基础/转化研究培训， MD/PhD 和博士研究员，在 28 名导师的指导下，并获得 2570 万美元的校外资助 资金（17.3 美元来自联邦）在埃默里大学建立了镰状细胞研究项目。 疾病、止血和血栓形成、造血和干细胞生物学、基因治疗和红细胞 生理学和输血医学被纳入儿科血液学最大的临床项目中 在该国，为儿童医院的临床和转化研究提供了大量患者 亚特兰大医疗保健与佐治亚理工学院和莫尔豪斯学院的合作伙伴关系 医学扩大师资导师库。每位学员将有一名实验室研究导师和一名临床导师。 共同导师促进与儿科血液学相关的基础或转化研究。 由 11 名年轻教师组成的初级导师将扩大未来导师的供应。 融入非常成功的儿科血液学/肿瘤学/骨髓移植 (BMT) Aflac 癌症和血液疾病中心的研究员计划，新的 HTP 将各招收 2 名研究员 每年提供2年的支持，5年内培养5-7名MD研究员和3-5名PhD博士后研究员。 将是研究员培训计划和相关实验室内的医学博士、医学博士/博士和博士研究员，如 以及根据之前的培训和研究成果选择的外部候选人， 除了严格的学术潜力外，还致力于非恶性血液学研究。 实验室研究培训，学员将参加伦理研究、部门研究课程 职业发展研讨会、资助写作和学术技能培训、研究会议、期刊俱乐部、 将为每位学员制定个人培训计划和研究金计划。 多学科奖学金监督委员会将监督进展情况，学员将展示他们的成果。 参加全国会议并制定职业发展（K 型）奖项申请。 充分利用埃默里大学广泛的研究资源，包括正式课程和学位 临床和转化研究项目可通过埃默里大学的 CTSA 项目建立。 该计划将使我们能够培训儿科非恶性血液学的下一代学术领导者。