U2C Administrative Core

U2C 管理核心

• 批准号: 10201602
• 负责人: Dean Paul Jones
• 金额: $ 6.28万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201602
• 关键词: Big Data; Biochemical; Cells; Chemicals; Collaborations; Communication; Communities; Complement; Data; Databases; Dedications; Development; Disease; Dissociation; Effectiveness; Environmental Health; Goals; Health; Human; Infrastructure; Ions; Knowledge; Laboratories; Lead; Leadership; Life; Maintenance; Movement; National Institute of Environmental Health Sciences; Pattern; Pharmacology; Research; Research Personnel; Resolution; Role; Sampling; Schedule; Science; Services; Structure; Support System; System; Testing; Time; Training; Universities; Work; Xenobiotic Metabolism; Xenobiotics; adduct; career development; design; environmental chemical; experience; flexibility; improved; innovation; laboratory facility; meetings; metabolomics; outreach; professor; programs; skills; success; tool; tool development; usability

Administrative Core Project Summary The Administrative Core serves critical leadership, organizational and identity roles for the Compound Identity Discovery Core (CIDC) at Emory University. Dr. Jones will serve as Core Director and maintain overall organization through regular interactions with MPIs Dr Miller, Dr Morgan and Dr Li. Dr Jones has expertise in metabolomics and long-term scientific collaborations and academic interactions with other proven scientific leaders of the Core, Dr Miller and Dr Morgan. The Core is designed to maintain a high level of flexibility for Dr Morgan's leadership in the Experimental Core to develop arrays of cell systems for targeted xenobiotic biochemical transformation while at the same time coordinating this with Dr Li's development of computational systems to support high throughput chemical identification. The Core is further designed to complement central tool development goals with activities of the Metabolomics Consortium, support service for exposome- related metabolite identification and metabolomics training and career development. Dr Miller, Director of the NIEHS-supported HERCULES Human Exposome Research Center at Emory, will be Co-Director for Exposome Outreach and Exposome Metabolite Identification. Dr Morgan will be Co-Director for Metabolomics Training and Career Development. Together, these investigators bring a high degree of organization and management experience to the Emory CIDC. The goals of the Core are to 1) Provide leadership and guidance for the Emory CIDC. The Core will work to assure that the complementary group of Emory CIDC laboratories and facilities work efficiently as a team to assure success in development of compound identification tools for xenobiotic metabolites. 2) Assure progress of the Computational Core and Experimental Core in achieving their objectives. These cores are distinct but interdependent; the Administrative Core will work to assure that the Computational Core and the Experimental Core each achieve its goals, thereby helping assure the overall success in tool development. 3) Develop an infrastructure for servicing needs of the exposome research community in identification of environmental metabolites associated with disease. The Administrative Core will work with HERCULES Human Exposome Research Center to develop a structure to support real-life testing of xenobiotic metabolite identification tools to benefit stakeholders and improve design and usability. 4) Facilitate communication between the Emory CIDC and the Metabolomics Consortium leadership, other Metabolomics Consortium components and stakeholders. The Administrative Core will serve as the primary conduit for interaction with the Metabolomics Consortium and will support additional outreach, training and career development objectives. The combined expertise and leadership skills of the Administrative Core will assure that the Emory CIDC achieves its goals to develop powerful new chemical identification tools that are scalable to identify hundreds of thousands of metabolites of environmental chemicals and other components of the human exposome.

行政核心项目摘要 行政核心为复合身份的批判性领导，组织和身份角色服务 埃默里大学的发现核心（CIDC）。琼斯博士将担任核心主任，并保持整体 通过与MPIS Miller博士，Morgan博士和Li博士进行定期互动。琼斯博士在 代谢组学和长期科学合作以及与其他经过验证的科学的学术互动 核心的领导人，米勒博士和摩根博士。该核心旨在维持DR的高度灵活性 摩根在实验核心中的领导才能开发针对有针对性异生物的细胞系统阵列 生化转化，同时将其与Li博士的计算发展进行协调 支持高通量化学识别的系统。核心旨在补充 中央工具开发目标通过代谢组学联盟的活动，支持服务的支持服务 相关的代谢物识别和代谢组学培训和职业发展。米勒博士，董事 埃默里（Emory）的Niehs支持的大力神人类外籍研究中心将担任联合主任 外展外展和外向代谢物识别。摩根博士将成为代谢组学的联合指导者 培训和职业发展。这些调查人员一起提出了高度的组织和 Emory CIDC的管理经验。核心的目标是1）提供领导和指导 对于Emory CIDC。核心将努力确保Emory CIDC实验室的补充小组 设施作为一个团队有效地工作，以确保开发复合识别工具的成功 异生物代谢物。 2）确保计算核心和实验核心的进展 他们的目标。这些岩心是不同的，但相互依存。行政核心将努力确保 计算核心和实验核心每个都实现了目标，从而有助于确保整体 工具开发的成功。 3）开发一个基础架构，以满足杂材研究的服务需求 鉴定与疾病相关的环境代谢产物的社区。行政核心将 与Hercules人类外籍人士研究中心合作，开发一种结构，以支持现实生活测试 异种生物代谢物识别识别工具，使利益相关者受益并提高设计和可用性。 4）便利 Emory CIDC与代谢组学联盟领导力之间的沟通，其他代谢组学 财团组件和利益相关者。行政核心将作为主要渠道 与代谢组学财团的互动，并将支持其他外展，培训和职业 发展目标。行政核心的组合专业知识和领导能力将确保 Emory CIDC实现了开发可扩展的强大新化学识别工具的目标 确定成千上万的环境化学品和其他成分的代谢产物 人类的外汇。