Neural Encoding and Auditory Perception in Cochlear Implant

人工耳蜗中的神经编码和听觉感知

• 批准号: 10197094
• 负责人: Shuman He
• 金额: $ 45.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197094
• 关键词: Acoustic Nerve; Acoustic Stimulation; Acoustics; Action Potentials; Adult; Adverse effects; Affect; Age; Age-Years; Auditory; Auditory Evoked Potentials; Auditory Perception; Auditory area; Auditory system; Basic Science; Behavioral; Clinical; Clinical Management; Cochlear Implants; Cognitive; Cues; Detection; Deterioration; Early identification; Elderly; Electric Stimulation; Electrophysiology (science); Event-Related Potentials; Evoked Potentials; Foundations; Goals; Habilitation; Hearing; Impaired cognition; Implant; Individual; Knowledge; Lead; Measures; Modification; Noise; Outcome; Outcome Measure; Patients; Pattern; Performance; Peripheral; Procedures; Process; Property; Protocols documentation; Psychophysics; Pulse Rates; Reaction Time; Recovery; Research; Speech; Speech Perception; Stimulus; Testing; Time; Variant; Voice; Work; clinical practice; cognitive function; comparison group; deafness; design; evidence base; experimental study; improved; individual variation; insight; neuroadaptation; neurophysiology; older patient; programs; rehabilitation strategy; relating to nervous system; response; signal processing; speech processing; tool; young adult

PROJECT SUMMARY/ABSTRACT Cochlear implant (CI) users who are 65 years or older typically show poorer speech perception performance than younger adult CI users, especially in competing background noise. The underlying mechanisms remain unclear. Whereas declined cognitive function has been proposed as the major factor, deteriorations in the auditory system have also been suggested to be the primary reason. As a result, there is no robust indicator for optimizing programming settings or habilitation strategies for older implanted patients. This study is designed to better understand underlying neurophysiological mechanisms of speech perception deficits in older CI users. Older listeners are known to have temporal processing deficits, and temporal cues are particularly important for discriminating speech in CI users. Therefore, the proposed study will focus on comparing peripheral and central auditory neural encoding of, and perceptual sensitivity to, temporal envelope cues between younger and older adult CI users. Aim 1 will assess group differences in temporal responsiveness of the auditory nerve in younger (< 60 years) and older (between 65 and 85 years) adult CI users. The group comparison will be done for three temporal properties of the auditory nerve: peri-stimulus neural adaptation, adaptation recovery and the accuracy of amplitude modulation encoding. Aim 2 will assess group differences in neural representation at the auditory cortex (i.e. cortical encoding) of, and perceptual sensitivity to, temporal gaps and voice onset time, as well as their association with speech perception in younger and older adult CI users. Aim 3 will evaluate contributions of differences in AN temporal responsiveness and cortical encoding of temporal gaps and amplitude modulation to variations in perceptual envelope sensitivity in individual adult CI users. For experiments in Aims 2 and 3, psychophysical procedures and electrophysiological measures of peripherally and centrally generated evoked potentials will be combined and applied in concert in the same CI users. In addition, cognitive functions will be evaluated and used as one of the predictors for behavioral results. Results of this study have substantial significance from both a basic science and a clinical management point of view. For example, these results will provide information about the contributions of peripheral vs central auditory functions, as well as auditory vs cognitive factors to perceptual sensitivity to temporal gaps and amplitude modulations, which is crucial for understanding underlying mechanisms of these auditory processes. These results will also provide information about whether the accuracy of neural encoding and processing of electrical hearing declines in older CI users, as well as at which level of the auditory system this decline, if any, exists. This information could potentially lead to developing objective tools for early identification of older CI patients who may need additional rehabilitation strategies. Given the importance of temporal processing for speech perception and the rapidly increasing number of older CI patients, experiments proposed in this application are of high scientific and translational significance.

项目摘要/摘要 65岁或以上的人工耳蜗（CI）用户通常表现出较差的语音感知 性能比年轻的成人CI使用者，尤其是在竞争背景噪音中。基础 机制仍然不清楚。尽管已经提出认知功能下降的主要因素，但 听觉系统中的恶化也被认为是主要原因。结果，有 没有可用于优化年长植入患者的编程设置或关联策略的强大指标。 这项研究旨在更好地了解语音感知的基本神经生理机制 老年CI用户的缺陷。众所周知，年长的听众有时间处理缺陷和时间提示 对于区分CI用户的语音尤为重要。因此，拟议的研究将重点放在 比较时间膜的外围和中央听觉神经编码以及感知敏感性 年轻人和老年人CI使用者之间的提示。 AIM 1将评估时间的群体差异 年轻（<60岁）及以上（65至85岁）成人CI的听觉神经的响应能力 用户。将对听觉神经的三个时间特性进行组比较：刺激性 神经适应性，适应性恢复和振幅调制编码的准确性。 AIM 2将评估 在听觉皮层（即皮层编码）和感知的神经表示的群体差异 对时间差距和声音发作时间的敏感性，以及它们与语音感知的联系 年轻和老年人CI使用者。 AIM 3将评估时间上差异的贡献 时间间隙的响应性和皮质编码和对感知变化的振幅调制 个别成人CI使用者的信封灵敏度。对于目标2和3的实验，心理物理程序 以及外围和集中产生的诱发电位的电生理测量 并在同一CI用户中申请。此外，认知功能将被评估并用作一个 行为结果的预测因素。这项研究的结果从两者的基本中具有重要意义 科学和临床管理的观点。例如，这些结果将提供有关 外围与中央听觉功能的贡献，以及听觉与认知因素对感知的贡献 对时间间隙和振幅调制的敏感性，这对于理解潜在的至关重要 这些听觉过程的机制。这些结果还将提供有关是否是否 较老的CI使用者以及在其中的神经编码和处理电气听力下降的准确性以及 听觉系统的水平存在这种下降（如果有的话）。这些信息可能会导致发展 可能需要其他康复策略的老年CI患者的客观工具。 鉴于时间处理对于语音感知的重要性和较大的旧数量 CI患者，在此应用中提出的实验具有很高的科学和翻译意义。

项目成果

Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.

• DOI: 10.1016/j.heares.2022.108643
• 发表时间: 2022-12
• 期刊: HEARING RESEARCH
• 影响因子: 2.8
• 作者: Skidmore, Jeffrey;Ramekers, Dyan;Bruce, Ian C.;He, Shuman
• 通讯作者: He, Shuman

The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users.

• DOI: 10.1097/aud.0000000000000919
• 发表时间: 2021
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: Skidmore J;He S
• 通讯作者: He S

Prediction of the Functional Status of the Cochlear Nerve in Individual Cochlear Implant Users Using Machine Learning and Electrophysiological Measures.

• DOI: 10.1097/aud.0000000000000916
• 发表时间: 2021
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: Skidmore J;Xu L;Chao X;Riggs WJ;Pellittieri A;Vaughan C;Ning X;Wang R;Luo J;He S
• 通讯作者: He S

A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.

一种从电诱发复合动作电位记录中去除伪影的新方法：单脉冲刺激。

• DOI: 10.1101/2024.01.17.24301435
• 发表时间: 2024
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Skidmore,Jeffrey;Yuan,Yi;He,Shuman
• 通讯作者: He,Shuman

Effect of Increasing Pulse Phase Duration on Neural Responsiveness of the Electrically Stimulated Cochlear Nerve.

• DOI: 10.1097/aud.0000000000000876
• 发表时间: 2020
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: He S;Xu L;Skidmore J;Chao X;Riggs WJ;Wang R;Vaughan C;Luo J;Shannon M;Warner C
• 通讯作者: Warner C