Auditory experience during the prenatal and perinatal period

产前和围产期的听觉体验

基本信息

批准号：
10197097
负责人：
Brian Bruce Monson
金额：
$ 15.44万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197097
关键词：
Abdomen Acoustics Address Affect Age Age-Months Air Animals Attentional deficit Audiology Auditory Auditory Brainstem Responses Biological Birth Brain Brain Stem Caring Central Auditory Processing Disorder Child Childhood Cognition Disorders Communication Data Development Devices Diagnosis Diagnostic Early Intervention Environment Exhibits Exposure to Fetal Development Fetus Foundations Goals Healthcare Hearing High Prevalence Human Impaired cognition Incubators Infant Infant Incubators Language Language Development Language Disorders Learning Length of Stay Liquid substance Longitudinal Studies Measures Mechanics Medical Medicine Morbidity - disease rate Mothers National Institute on Deafness and Other Communication Disorders Neonatal Intensive Care Units Neurodevelopmental Disorder Neurosciences Newborn Infant Noise Outcome Pathology Pattern Perinatal Population Positioning Attribute Pregnant Women Premature Birth Premature Infant Reporting Research Risk Sensorineural Hearing Loss Solid Speech Survival Rate Survivors Testing Therapeutic Intervention Time Underserved Population United States Uterus Voice auditory neuropathy auditory pathway auditory processing circadian cohort communication behavior critical period effective intervention effective therapy experience exposed human population follow-up improved improved outcome in utero infancy insight intrauterine environment language processing neurodevelopment perinatal brain perinatal period personalized approach prenatal prospective recruit sound stem therapy design transmission process

项目摘要

Within the United States alone, over a half-million infants are born premature each year. While medical advances have dramatically improved survival rates, long-term morbidities related to auditory function are common. The preterm population suffers from a relatively high prevalence of sensorineural hearing loss, auditory neuropathy/dys-synchrony, and central auditory processing disorder. Even preterm infants in whom no specific auditory pathology has been diagnosed exhibit cognitive impairments related to auditory processing, including auditory attention deficits, language processing deficits, and other speech/language communication deficits. Despite these facts, a solid understanding of the impact of premature birth on auditory neurodevelopment is lacking. Possible effects of the acoustic environment are unknown. The long-term objective of this research is to characterize the effect of premature birth on auditory neurodevelopment and communication behavior to aid in improving best medical practices and therapeutic interventions for preterm infants. In this study, we propose to measure the effects of auditory input during the preterm period on neurodevelopmental outcomes. There are three specific aims. In Aim 1 we will recruit a cohort of preterm infants in the neonatal intensive care unit (NICU) to prospectively measure their auditory input during hospital stay. We will quantify detailed auditory experience in the NICU and determine how this differs from intrauterine auditory experience. In Aim 2 we will determine the effect of premature birth on auditory function at 3 months of age. In Aim 3 we will determine the relationship between our measured parameters of perinatal auditory experience and auditory function in infancy. The proposed study will lay the foundation for a longitudinal study aimed to determine the effect of auditory experience in the NICU on long-term auditory and language development. Valuable insight will be gained as to how premature birth and NICU environment might affect auditory neurodevelopment. Results of these studies will ultimately aid in identifying (1) effective interventions to optimize NICU auditory experience and (2) potential early-intervention therapies for NICU infants at greatest risk for auditory and language deficits later in childhood.

仅在美国，每年有超过50万的婴儿出生于早产。同时医疗进步已大大提高了生存率，与听觉功能相关的长期病毒是常见的。早产遭受感官听力损失的率相对较高的患病率听觉神经病/DYS合成和中央听觉处理障碍。甚至是早产儿已诊断出特定的听觉病理学表现出与听觉处理相关的认知障碍，包括听觉注意力缺陷，语言处理缺陷以及其他语音/语言交流缺陷。尽管有这些事实，但对早产对听觉的影响有着深入的了解缺乏神经发育。声学环境的可能影响尚不清楚。长期这项研究的目的是表征早产对听觉神经发育的影响沟通行为有助于改善早产的最佳医疗实践和治疗干预措施婴儿。在这项研究中，我们建议在早产期间测量听觉输入的影响神经发育结果。有三个特定的目标。在AIM 1中，我们将招募一群早产新生儿重症监护病房（NICU）的婴儿前瞻性地衡量其听觉输入停留。我们将量化NICU中的详细听觉经验，并确定这与宫内的不同听觉经验。在AIM 2中，我们将确定早产对3个月后听觉功能的影响年龄。在AIM 3中，我们将确定围产期听觉的测量参数之间的关系婴儿期的经验和听觉功能。拟议的研究将为纵向研究奠定基础旨在确定NICU中听觉经验对长期听觉和语言的影响发展。关于早产和NICU环境可能如何影响，有价值的见解将获得听觉神经发育。这些研究的结果最终将有助于识别（1）有效干预措施优化NICU的听觉经验和（2）最大的NICU婴儿的潜在潜在干预疗法童年后期有听觉和语言缺陷的风险。