Administrative Core

行政核心

• 批准号: 10190647
• 负责人: Kyu Y Rhee
• 金额: $ 20.63万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-13 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10190647
• 关键词: Address; Animal Model; Biology; Budgets; Businesses; Characteristics; Communication; Conflict (Psychology); Development; Discipline; Drug Targeting; Ensure; Epidemiology; Equipment; Funding; Genes; Genetic; Goals; In Vitro; Intervention; Liquid substance; Metabolic; Metabolic Pathway; Microbiology; Modification; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Property; Protocols documentation; Research; Research Personnel; Resolution; Role; Route; Supervision; Testing; Time; Translating; Travel; Work; aerosolized; clinical phenotype; conflict resolution; data exchange; data sharing; gene function; material transfer agreement; meetings; novel strategies; programs; respiratory; response; synergism; transmission process; tuberculosis treatment

ABSTRACT The overall goal of the Administrative Core is to ensure timely and effective execution of proposed work through management, coordination and supervision of the Project and Core Leaders and research personnel and resolution of any conflicts that may arise. The Administrative Core will ensure that the interaction of the Projects and Core B are optimized so as to succeed in the following goals: identification of new gene functions, drug targets and metabolic responses in Mtb, correlation of these with the transmission phenotype of clinical isolates, development of new tests for a TB treatment's transmission-blocking potential, new animal models for aerogenic transmission of TB that allow experimental modification of the genetics of Mtb and the characteristics of aerosolized droplets, and consideration of new approaches to reduce R0.

抽象的 行政核心的总体目标是确保及时有效执行拟议的工作 通过管理，协调和监督项目以及核心领导者和研究人员 并解决可能出现的任何冲突。管理核心将确保 项目和核心B被优化，以便在以下目标中取得成功：识别新基因功能， MTB中的药物靶标和代谢反应，这些反应与临床的传播表型的相关性 分离株，开发针对结核病治疗的传输障碍潜力的新测试，新的动物模型 结核病的充气传播允许对MTB和MTB遗传学的实验性修饰 雾化液滴的特征，以及考虑减少R0的新方法。