ShEEP Request for an X-Ray Irradiation System

ShEEP 请求 X 射线辐照系统

• 批准号: 10177392
• 负责人: David Wald
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177392
• 关键词: 2019-nCoV; American; Anesthesia procedures; Animals; Area; Bacteria; Biological; Biology; Bone Marrow Transplantation; COVID-19; Cell Culture Techniques; Cells; Ceramics; Cesium; Collaborations; Collimator; Devices; Diagnostic radiologic examination; Disease Progression; Dose; Ensure; Environment; Equipment; Fostering; Funding; Health; Hematopoiesis; Homologous Transplantation; Human; Image; Imaging Device; Immune response; Individual; Isoflurane; Lead; Location; Longevity; Maintenance; Malignant Neoplasms; Medical center; Metals; Minor; Modeling; Multimodal Imaging; Mus; Mutation; Neurologic; Output; Play; Radiation Dose Unit; Radiation exposure; Radioactive; Reagent; Records; Research; Research Personnel; Roentgen Rays; Role; SARS-CoV-2 infection; Safety; Sampling; Security; Sheep; Site; Specimen; Sterility; Supervision; System; Technology; Time; Time Factors; Training; Transplantation; Tube; Veterans; Virus; Work; animal facility; animal imaging; anticancer research; base; cancer therapy; cost; design; high efficiency particulate air filter; image guided radiation therapy; imaging system; instrument; irradiation; neoplastic cell; nervous system disorder; programs; radiation effect; research study; touchpad; waiver; x-ray irradiation

The requested equipment is an X-RAD 320 large chamber self-contained X-ray system from Precision X-ray Inc. This equipment would significantly advance the existing research of a large number of VA researchers, enable the extension of current studies in new directions and foster collaborations among multiple VA investigators. The irradiator has built in functionality to perform both X-ray irradiation as well as bioluminescent imaging of small animals. There is currently no equipment at the Cleveland VA Medical Center to perform irradiation of any sort for research studies or bioluminescent imaging of small animals. This instrument will play a major role in enabling VA research to be performed on site at the Cleveland VA Medical Center that currently is not feasible and can only be performed off site. Acquisition of the irradiator will greatly enhance Cleveland VA research efforts in a variety of fields including cancer research, neurological research and studies on SARS-COV2. In addition to being the only instrument that incorporates imaging and irradiation into a single device, a major advantage of this instrument is its safety. Unlike radioactive irradiators that have major safety and regulatory concerns, this X-ray based instrument is safe and reliable. The Cleveland VA research program has 4 Major and several minor users whose research will be significantly impacted by this instrument. In addition, it is expected that the availability of this currently unavailable technology will help foster new directions for other local VA researchers. All of the users have strong track records of VA and other national funding that will help support the use of this machine. The PI will help lead the efforts to supervise and maintain the equipment as well as train other users. Overall, the purchase of the X-RAD 320 irradiator will fill a major unmet need for many VA researchers and facilitate future research efforts.

请求的设备是X-RAD 320大型室独立X射线系统 Precision X射线公司。该设备将大大提高大型研究的现有研究 VA研究人员的数量，使当前研究在新方向上扩展并促进 多个VA调查人员之间的合作。辐照器具有功能 对小动物进行X射线照射以及生物发光成像。有 目前，克利夫兰弗吉尼亚州医疗中心没有设备进行任何形式的辐照 小动物的研究或生物发光成像。该乐器将演奏专业 在使VA研究能够在Cleveland VA医疗中心进行现场进行的角色 目前不可行，只能在现场进行。获取辐射器将 在包括癌症在内的各个领域的克利夫兰VA研究工作大大增强了 SARS-COV2的研究，神经研究和研究。除了是唯一的 将成像和照射纳入单个设备的仪器，这是一个主要优势 该工具的安全性。与具有主要安全性和的放射性辐照器不同和 监管问题，这种基于X射线的工具是安全可靠的。克利夫兰弗吉尼亚州 研究计划有4位专业和几个未成年人，其研究将大大显着 受此仪器的影响。此外，预计目前的可用性 不可用的技术将为其他本地VA研究人员促进新方向。所有人 用户拥有VA和其他国家资金的强大记录，这将有助于支持 使用这台机器。 PI将帮助领导监督和维护设备作为 以及培训其他用户。总体而言，购买X-RAD 320辐射器将填充一个未满足的主要内容 需要许多VA研究人员，并促进未来的研究工作。