ShEEP-IC: Request to purchase MAGNETOM Skyra 3T complete concurrent field monitoring and motion correction system upgrade

ShEEP-IC：请求购买 MAGNETOM Skyra 3T 完整的并发现场监控和运动校正系统升级

• 批准号: 10175286
• 负责人: Pratik Mukherjee
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175286
• 关键词: Angiography; Automation; Back; Brain; Breathing; Calibration; Child; Clip; Collaborations; Computer software; Computers; Cost Savings; Data; Data Storage and Retrieval; Development; Diagnostic; Disease; Elderly; Environment; Equipment; Faculty; Frequencies; Funding; Funding Mechanisms; Head; Health; Image; Imaging Device; Imaging technology; Institution; Kinetics; MRI Scans; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Measures; Mental Depression; Mental disorders; Minor; Monitor; Morphologic artifacts; Motion; Pathology; Patients; Pattern; Phase; Physiologic pulse; Physiological; Post-Traumatic Stress Disorders; Production; RF coil; Real-Time Systems; Research; Research Personnel; Research Project Grants; Resolution; Respiration; Scanning; Schizophrenia; Services; Sheep; Site; System; Technology; Time; Training; Traumatic Brain Injury; Update; Veterans; accurate diagnosis; addiction; catalyst; chronic pain; clinical application; correctional system; data streams; feeding; image reconstruction; improved; inter-institutional; magnetic field; nervous system disorder; neurovascular; non-invasive imaging; obese patients; patient population; programs; reconstruction; recruit; technology development; tool; treatment planning

We are requesting funds to purchase complete concurrent field monitoring and motion correction system upgrade for our MAGNETOM Skyra 3T scanner at a budgetary quote of $816,370 (see 13_VA_Appendix_3_Quote.pdf). This upgrade comprises of two main components that will be used simultaneously for synergistic improvements to scan spatial resolution, robustness and quality. Upgrades for the Siemens 3T Skyra MRI scanner: 1. Kineticor Motion Correction System, KC-3T70 ($132,500) 2. Skope Complete Concurrent Monitoring System ($683,870) The Kineticor Motion Correction System uses a low profile, quad camera system to monitor and correct for patient head motion in real time during the MRI scan acquisition. This is achieved by feeding back the motion estimates to the scanner to update the imaging gradients as well as RF frequency and phase on TR by TR basis. The Skope Complete Concurrent Monitoring System uses 16 field probes to measure and correct for artifact inducing dynamic fluctuations in the main magnetic field (e.g. due to respiration, head motion, or other MRI system imperfections). The Skope Complete system includes the Neurocam (a dedicated RF head coil integrated with the 16 field probes) as well as the Clip-on Camera (a separate set of 16 field probes) for users who wish to perform concurrent monitoring with their existing Siemens RF head coils. Critically, not only would the proposed upgrade facilitate non-invasive imaging of the whole brain at unprecedented spatial resolutions, but it would also allow for robust, high quality imaging of challenging patient populations - including those who have difficulty keeping still (e.g. children, elderly, and those with neurological disorders) as well as those who are prone to generate physiologically induced image artifacts (e.g. large, obese patients and those with irregular breathing patterns). As such, existing research projects would also reap both time and cost savings since fewer subjects’ data would be lost or need to be re-acquired due to poor image quality. Funding this proposal would also greatly augment our ongoing efforts to recruit high-quality faculty candidates as well as efforts to attract cross-institution collaborators, which help keep the VA at the cutting edge of imaging technology development and clinical applications - ultimately supporting veterans afflicted with disease, such as neurological (TBI) and psychiatric (PTSD) disorders, for whom adequate diagnostic tools are not yet available.

我们正在申请资金购买完整的并发现场监控和运动校正系统 升级我们的 MAGNETOM Skyra 3T 扫描仪，预算报价为 816,370 美元（请参阅 13_VA_Appendix_3_Quote.pdf）此升级包含两个将使用的主要组件。 同时协同改进扫描空间分辨率、稳健性和质量。 西门子 3T Skyra MRI 扫描仪的升级： 1. Kineticor运动校正系统，KC-3T70（132,500美元） 2. Skope完整的并发监控系统（683,870美元） Kineticor 运动校正系统使用低调的四摄像头系统来监控和校正 MRI 扫描采集期间患者头部的实时运动是通过反馈运动来实现的。 对扫描仪进行估计，以更新 TR 上的成像梯度以及 RF 频率和相位 Skope 完整并发监测系统使用 16 个现场探头进行测量和校正。 引起主磁场动态波动的伪影（例如，由于呼吸、头部运动或其他原因） Skope Complete 系统包括 Neurocam（专用射频头部线圈）。 与 16 个现场探头集成）以及供用户使用的夹式相机（一组单独的 16 个现场探头） 希望使用现有的西门子射频头部线圈进行并发监控的人。 至关重要的是，拟议的升级不仅可以促进整个大脑的非侵入性成像 前所未有的空间分辨率，但它也可以对具有挑战性的患者进行稳健、高质量的成像 人群 - 包括那些难以保持静止的人群（例如儿童、老人和神经系统疾病患者） 疾病）以及那些容易产生生理引起的图像伪影的人（例如，大的、 肥胖患者和呼吸模式不规则的患者）因此，现有的研究项目也将如此。 节省时间和成本，因为更少的受试者数据会丢失或因质量较差而需要重新获取 资助这项提案也将极大地增强我们为招募高素质人才所做的持续努力。 教师候选人以及吸引跨机构合作者的努力，这有助于保持 VA 的地位 最前沿的成像技术开发和临床应用 - 最终支持退伍军人 患有神经系统疾病 (TBI) 和精神疾病 (PTSD) 等疾病的人，对于他们来说， 诊断工具尚不可用。