ISS MetaOx Tissue Oxygen Consumption Monitor

ISS MetaOx 组织耗氧量监测仪

• 批准号: 10175201
• 负责人: Michael Douglas Nelson
• 金额: $ 24.81万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175201
• 关键词: Address; Area; Blood flow; Cerebrum; Computer software; Core Facility; Devices; Diffuse; Doppler Ultrasound; Extramural Activities; Faculty; Frequencies; Funding; Hemoglobin; Infrastructure; Lasers; Magnetic Resonance Imaging; Measurement; Metabolism; Microspheres; Monitor; Muscle; Near-Infrared Spectroscopy; Organ; Oxygen; Oxygen Consumption; Perfusion; Physiologic pulse; Regulation; Research; Research Project Grants; Skeletal Muscle; Spectrum Analysis; Spin Labels; System; Techniques; Tissues; Xenon; college; design; instrument; member; multidisciplinary; temporal measurement; tool; user-friendly

Project Summary/Abstract Diffuse Correlation Spectroscopy (DCS) is a powerful new tool to assess cerebral and skeletal muscle microvascular perfusion. DCS is completely noninvasive, has excellent temporal resolution, and has been validated in a variety of organs and tissues, against several different standards, including laser Doppler , Xenon- CT, fluorescent microsphere flow measurements, arterial spin labelled-MRI, and pulse-wave Doppler ultrasound. Combining DCS with conventional near-infrared spectroscopy (NIRS)—an established technique for characterizing the transport and utilization of oxygen—introduces exciting new possibilities for understanding the determinants of cerebral and muscle oxygen utilization, at the microvascular level. The specific aim of this application is to acquire an ISS MetaOx Tissue Oxygen Consumption Monitor – currently the only commercially available DCS device on the market. This instrument is well suited for a multidisciplinary core facility due to its user-friendly integrated software, and robust analysis features. It address all of the limitations currently associated with our current NIRS/DCS systems, including quantitative measurement of hemoglobin concentration using Frequency-Domain Near-Infrared Spectroscopy. Moreover, its cross-organ versatility extends its research application beyond cerebral oxygen metabolism—for which it was originally designed for— allowing UTA faculty to also assess the determinants of skeletal muscle oxygen metabolism and skeletal muscle blood flow regulation; an area of research that UTA faculty are actively involved in. The MetaOx will significantly enhance the research and educational infrastructure of UTA, and will stimulate collaborative research projects between a large group of extramurally funded faculty members, spanning multiple Colleges and many Departments across campus.

项目摘要/摘要 弥漫性相关光谱（DC）是评估脑肌肉的强大新工具 微血管灌注。 DC完全无创，具有出色的临时分辨率，并且已经是 根据多种不同的标准在各种器官和组织中进行了验证，包括激光多普勒，Xenon- CT，荧光微球流量测量，动脉自旋标记MRI和脉冲波多普勒超声。 将直流与常规近红外光谱（NIR）相结合 - 一种已建立的技术 表征氧的运输和利用 在微血管水平上的大脑和肌肉氧的决定因素。这个的具体目的 应用是获取ISS Metaox Tissue氧消耗监视器 - 目前是唯一的商业上 市场上可用的DCS设备。该乐器非常适合多学科的核心设施 用户友好的集成软件和强大的分析功能。它解决了当前的所有限制 与我们当前的NIR/DCS系统相关，包括对血红蛋白的定量测量 使用频域近红外光谱浓度浓度。此外，它的跨器官多功能性 将其研究应用扩展到脑氧代谢之外，因为它最初是为此设计的 允许UTA教师还可以评估骨骼肌氧代谢和骨骼肌的决定者 血流调节； UTA教师积极参与的研究领域。 增强UTA的研究和教育基础设施，并将刺激协作研究项目 在一大批由室外资助的教职员工之间，跨越了多所大学 整个校园的部门。

项目成果

DCS blood flow index underestimates skeletal muscle perfusion in vivo: rationale and early evidence for the NIRS-DCS perfusion index.

DCS 血流指数低估了体内骨骼肌灌注：NIRS-DCS 灌注指数的基本原理和早期证据。

• DOI: 10.1117/1.jbo.29.2.020501
• 发表时间: 2024
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Bartlett,MilesF;Oneglia,AndrewP;Ricard,MarkD;Siddiqui,Ashfaq;Englund,ErinK;Buckley,ErinM;Hueber,DennisM;Nelson,MichaelD
• 通讯作者: Nelson,MichaelD