Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.

回顾性单图像多端点分析 (SIMPL) 定义射血分数保留的心力衰竭的病理生理机制。

• 批准号: 10580172
• 负责人: Michael Douglas Nelson
• 金额: $ 12.56万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10580172
• 关键词: Activities of Daily Living; Age; Aorta; Area; Automobile Driving; Clinical; Communities; Data; Data Set; Databases; Diabetes Mellitus; Diagnosis; Disease; EFRAC; Evaluation; Exercise Tolerance; Fatty acid glycerol esters; Functional disorder; Funding; Future; Group Meetings; Heart failure; Hypertension; Image; Image Analysis; Individual; Investigation; Left atrial structure; Left ventricular structure; Malignant Neoplasms; Methods; Modeling; Molecular; Monitor; Morbidity - disease rate; Multivariate Analysis; Myocardium; National Heart, Lung, and Blood Institute; Nature; Obesity Epidemic; Organ; Patient Outcomes Assessments; Patients; Pericardial body location; Phenotype; Positioning Attribute; Prevalence; Prognosis; Public Health; Quality of life; Research; Research Methodology; Research Priority; Resolution; Right atrial structure; Right ventricular structure; Study Section; Survival Rate; Therapeutic; Tissues; United States; Validation; aging population; biobehavior; cardiac magnetic resonance imaging; cohort; effective therapy; exercise intolerance; experimental study; heart function; human data; innovation; mortality; novel; preservation; prevent; secondary analysis; sex; tool; working group

Project Summary Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of heart failure, is associated with high morbidity and mortality, with increasing prevalence and worsening prognosis. Quality-of-life in HFpEF is as poor or worse than heart failure with reduced ejection fraction, in large part because of severe exercise intolerance; the primary manifestation of this bourgeoning condition. Per funding announcement PAR-20-078 which supports the use of existing human datasets for well-focused secondary analyses to investigate new methods that have the potential for significant impact on NHLBI relevant biomedical or biobehavioral research, we will leverage an existing database of cardiac magnetic resonance images in a cohort of well-phenotyped patients with HFpEF and age- and sex-matched healthy controls to comprehensively identify and characterize pathophysiologic mechanisms driving HFpEF. We will use a novel Single Image Multi-endPoint anaLysis (SIMPL) approach to compare four chamber cardiac function (right atrium, right ventricle, left atrium, left ventricle), aortic distensibility, and pericardial fat burden between HFpEF and healthy controls, and to determine their independent and combined association with exercise tolerance and quality of life.

项目摘要 心力衰竭，保留的射血分数（HFPEF）是心力衰竭的最常见形式，是相关的 发病率和死亡率高，患病率和预后恶化。 HFPEF的生活质量 比心力衰竭差或差，射血分数减少，这在很大程度上是由于严重的运动 不宽容；这种高产条件的主要表现。每公告PAR-20-078 这支持使用现有人类数据集进行专注的次要分析以调查新的 对NHLBI相关的生物医学或生物行为研究有重大影响的方法， 我们将利用一系列良好的型号中的心脏磁共振图像的现有数据库 患有HFPEF以及年龄和性别匹配的健康对照的患者，以全面识别和表征 驱动HFPEF的病理生理机制。我们将使用新颖的单图多点分析 （简单）比较四个室内心脏功能的方法（右心室，右心室，左心房，左 心室），HFPEF和健康对照之间的主动脉膨胀性和心包脂肪负担，并确定 他们与运动耐受性和生活质量的独立和联合结合。