Small Animal Imaging Shared Resource

小动物成像共享资源

基本信息

批准号：
10170627
负责人：
RALPH P. MASON
金额：
$ 9.4万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10170627
关键词：
Acetates American Anatomy Animal Experimentation Animal Housing Animals Area Award Biodistribution Budgets Cancer Biology Cancer Center Planning Grant Cancer Center Support Grant Chemicals Choline Clinic Clinical Trials Communication Companions Complement Comprehensive Cancer Center Consult Consultations Cyclotrons Data Development Doctor of Philosophy Drug Kinetics Drug Targeting Ensure Equipment Ethics Evaluation Functional disorder Funding Gastroenterology Genetic Engineering Goals Grant Image Imaging Device Imaging Techniques Imaging technology ImmunoPET Immunooncology Individual Infrastructure Intervention Investigation Isotope Labeling Isotopes Journals Label Laboratories Leadership Link Magnetic Resonance Imaging Malignant Neoplasms Medical center Metabolism Methods Misonidazole Multimodal Imaging NCI Center for Cancer Research National Cancer Institute Nature Neurosciences Optics PET/CT scan Peer Review Performance Prognostic Marker Publications Publishing Radiation Radiochemistry Radioisotopes Radiolabeled Reagent Research Research Personnel Research Project Grants Resource Sharing Resources Series Services Small Animal Imaging Shared Resource Societies Technology Testing The Sun Therapeutic Therapeutic antibodies Tracer Training Translational Research Translations Ultrasonography Visualization Work anatomic imaging animal imaging anticancer research base cellular imaging clinical investigation community center cost experience fluorodeoxyglucose germ free condition image guided imaging approach imaging biomarker imaging modality improved in vivo insight instrument instrumentation irradiation meetings member molecular imaging novel novel strategies novel therapeutic intervention novel therapeutics nuclear imaging optical imaging optoacoustic tomography outreach pre-clinical precision oncology programs receptor response single photon emission computed tomography success symposium theranostics tool tumor tumor hypoxia

项目摘要

The Small Animal Imaging Shared Resource (SAISR) at Simmons Comprehensive Cancer Center (SCCC) is a comprehensive small animal multimodality imaging resource that facilitates advances in the understanding of cancer biology and the development of novel therapeutics. The SAISR enables noninvasive assessment of tumor development, progression, and response to therapy based on multiple imaging technologies, including optical, ultrasound, photoacoustics, MRI, CT, SPECT, and PET/CT. In addition to anatomical visualization, the SAISR provides spatial and functional context for prognostic biomarkers and theranostic interventions. Under the leadership of Ralph P. Mason, PhD, the SAISR facilitates and integrates pathophysiology, metabolism, and receptor target identification with anatomical imaging. The SAISR provides SCCC investigators with assisted and unassisted usage of imaging technologies, consultations on optimal imaging approaches, and hands-on training in the use of imaging modalities. Since the last renewal, the SAISR has incorporated several new approaches in order to stay at the leading edge of technology. Important enhancements in infrastructure and capabilities include new photoacoustic tomography and access to short-lived isotopes generated by a new cyclotron that provides multiple tracers, including 18F-MISO, 11C-acetate, and choline, that can be observed with a new Mediso PET/CT scanner. There have also been substantial upgrades to the MRI facilities that significantly expand the new preclinical radiation services so that investigators can use MRI and image-guided irradiation inside a specific pathogen-free vivarium, complementing the existing instruments in conventional animal housing areas. These capabilities of the SAISR were utilized by 41 investigators across four SCCC research programs in 2019 and provided key data and insights to support the success of more than 30 peer-reviewed, funded research project grants and 119 peer-reviewed publications since 2014, including work published in high-impact journals such as Nature, Nature Communications, Nature Neurosciences, Journal of Clinical Investigation, Gastroenterology, and the Journal of the American Chemical Society. In summary, the SAISR advances, supports, and provides important cancer research imaging modalities to the SCCC community, enabling them to efficiently test new therapeutic strategies in vivo as well as facilitate companion studies in clinical trials.

西蒙斯综合癌症中心 (SCCC) 的小动物成像共享资源 (SAISR) 是一个全面的小动物多模态成像资源，有助于加深对小动物多模态成像的理解癌症生物学和新疗法的开发。 SAISR 能够对肿瘤进行无创评估基于多种成像技术的治疗的发展、进展和反应，包括光学、超声、光声、MRI、CT、SPECT 和 PET/CT。除了解剖可视化之外，SAISR 为预后生物标志物和治疗诊断干预提供空间和功能背景。下在 Ralph P. Mason 博士的领导下，SAISR 促进并整合了病理生理学、新陈代谢和通过解剖成像进行受体靶标识别。 SAISR 为 SCCC 调查人员提供协助成像技术的独立使用、最佳成像方法的咨询以及实践使用成像方式的培训。自上次更新以来，SAISR 纳入了多项新内容方法以保持技术领先地位。基础设施和技术方面的重要改进能力包括新的光声断层扫描和获取由新的短寿命同位素回旋加速器提供多种示踪剂，包括 18F-MISO、11C-乙酸盐和胆碱，可以用新型 Mediso PET/CT 扫描仪。 MRI 设施也进行了大幅升级，这显着扩大新的临床前放射服务，以便研究人员可以使用 MRI 和图像引导放射位于特定的无病原体动物园内，补充了传统动物圈舍中的现有仪器地区。 SAISR 的这些功能被四个 SCCC 研究项目的 41 名研究人员利用 2019 年，并提供了关键数据和见解，以支持 30 多个经过同行评审、资助的项目取得成功自 2014 年以来获得研究项目资助和 119 篇同行评审出版物，包括在高影响力杂志上发表的作品 Nature、Nature Communications、Nature Neurosciences、Journal of Clinical Investigation 等期刊胃肠病学和美国化学会杂志。总之，SAISR 的进展是：支持并向 SCCC 社区提供重要的癌症研究成像模式，使他们能够有效地在体内测试新的治疗策略并促进临床试验中的伴随研究。