Administrative Supplement to Harnessing Alkyl Amines and Alkyl Alcohols in Cross-Coupling

在交叉偶联中利用烷基胺和烷基醇的行政补充

• 批准号: 10798396
• 负责人: Mary P Watson
• 金额: $ 8.61万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10798396
• 关键词: 14 year old; 3-Dimensional; Administrative Supplement; Alcohols; Amines; Awareness; Biological; Coupling; Deterioration; Development; Goals; High Pressure Liquid Chromatography; Liquid substance; Medicine; Methods; Parents; Performance; Public Health; Research; Research Support; drug development; enantiomer; human disease; instrument; programs

ABSTRACT This supplement to R35 GM131816 is directed towards the purchase of a Shimadzu Nexera™ Ultra High Performance Liquid Chromatograph (UHPLC) for the efficient determination of enantiomeric excess of organic compounds. Because of the differing biological activities of enantiomers, efficient methods are required to prepare bioactive molecules in high enantiomeric purity. Recognizing this important need, the development of new methods to prepare highly enantioenriched organic compounds is a major focus of the parent research program. The proposed UHPLC instrument will replace a rapidly deteriorating 14-year-old HPLC, which has been a critical workhorse instrument to enable the R35-supported research.

抽象的 R35 GM131816 的此补充材料旨在购买 Shimadzu Nexera™ Ultra High 高效液相色谱仪 (UHPLC)，用于有效测定对映体过量的有机物 由于对映体的生物活性不同，需要有效的方法来分析。 认识到这一重要需求，开发了高对映体纯度的生物活性分子。 制备高度对映体富集的有机化合物的新方法是母公司研究的主要焦点 拟议的 UHPLC 仪器将取代已经使用了 14 年且性能迅速恶化的 HPLC。 一直是 R35 支持的研究的关键主力仪器。

项目成果

Stitching two chiral centers with one catalyst.

用一种催化剂缝合两个手性中心。

• 发表时间: 2020
• 作者: Xu, Jianyu;Watson, Mary P
• 通讯作者: Watson, Mary P

Nickel-Catalyzed, Stereospecific C-C and C-B Cross-Couplings via C-N and C-O Bond Activation.

通过 C-N 和 C-O 键激活进行镍催化、立体特异性 C-C 和 C-B 交叉偶联。

• DOI: 10.1021/acscatal.0c05484
• 发表时间: 2021-02-05
• 期刊: ACS catalysis
• 影响因子: 12.9
• 作者: Xu J;Bercher OP;Talley MR;Watson MP
• 通讯作者: Watson MP