PROGNOSTIC RADIOLOGY AND THE PATHOPHYSIOLOGY OF TUMORS

预后放射学和肿瘤病理生理学

• 批准号: 8363897
• 负责人: RALPH P. MASON
• 金额: $ 0.8万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363897
• 关键词: Clinic; Development; Disease; Dose; Enzyme Activation; Functional disorder; Funding; Goals; Grant; Growth and Development function; Hypoxia; Investigation; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Measurement; Metabolism; National Center for Research Resources; Optics; Oxygen; Oxygen measurement, partial pressure, arterial; Oxygen saturation measurement; Patients; Physiology; Principal Investigator; Prostatic Neoplasms; Protons; Radiation; Radiation therapy; Radiology Specialty; Research; Research Infrastructure; Resistance; Resources; Source; Techniques; Testing; Therapeutic; Tissues; Translations; Tumor Oxygenation; United States National Institutes of Health; blood oxygen level dependent; cost; in vivo; novel strategies; pre-clinical; prognostic; response; tumor; tumor growth

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this research is to gain a comprehensive understanding of tumor physiology as related to tumor growth, development and response to therapy. A number of nonNMR approaches such as optical techniques are under development, However, we continue to pursue our MRI efforts related to measurement of oxygen tension and enzyme activation. Specifically, we will develop, demonstrate, and evaluate a novel approach to assessing tumor oxygenation with a view to rapid translation to the clinic. We believe it will be most pertinent to high dose hypofractionated radiotherapy in diseases such as prostate cancer. DOCENT (Dynamic Oxygen Challenge Evaluated by NMR T1 and T2*) exploits BOLD (blood oxygen level dependent) and TOLD (tissue oxygen level dependent) contrast to non-invasively detect changes in tumor oxygenation using proton MRI. We propose to develop DOCENT as a robust prognostic test to reveal tumor hypoxia. While the investigations proposed here are entirely pre-clinical, we believe they will demonstrate a strong rationale for rapid implementation in patients. Aim 1 will rigorously demonstrate the ability of DOCENT to categorize tumors as hypoxic (resistant or responsive) or oxic by comparison with 19F MR oximetry. Aim 2 will examine whether DOCENT does indeed predict response to hypofractionated radiation in subcutaneously growing prostate tumors. Aim 3 will extend studies to orthotopic prostate tumors. Aim 4 will seek to overcome therapeutic resistance of hypoxic tumors by including a radiation boost.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这项研究的目的是对与肿瘤生长，发育和对治疗的反应有关。 正在开发许多非NMR方法，例如光学技术，但是，我们继续从事与测量氧气张力和酶激活有关的MRI工作。 具体而言，我们将开发，证明和评估一种评估肿瘤氧合的新方法，以快速转化为诊所。我们认为，这将与前列腺癌等疾病中的高剂量低分化放疗最相关。 DOCTEN（由NMR T1和T2*评估的动态氧挑战）利用了大胆（血氧水平依赖性），并告诉（组织氧水平依赖性）与非侵入性检测使用质子MRI的肿瘤氧合变化形成鲜明对比。我们建议开发作为强大的预后测试，以揭示肿瘤缺氧。 尽管这里提出的调查完全是临床前的，但我们认为它们将证明在患者中快速实施的有力理由。 AIM 1与19F MR血氧饱和度相比，将严格证明DOCENT将肿瘤分类为低氧（抗性或反应性）或氧的能力。 AIM 2将检查Docent是否确实可以预测皮下生长的前列腺肿瘤中对低分辐射的反应。 AIM 3将将研究扩展到原位前列腺肿瘤。 AIM 4将寻求通过包括辐射提升来克服缺氧肿瘤的治疗性抗性。