Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future Generations

为子孙后代维护和扩展 CHAMACOS 流行病学队列基础设施

基本信息

批准号：
10166467
负责人：
Brenda Eskenazi
金额：
$ 11.38万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10166467
关键词：
Administrative Supplement Affect Agriculture Allergens Arylesterase Biological Biological Assay Biological Specimen Banks Birth Blood Chemicals Child Cohort Studies Collaborations Complex DNA Methylation Data Data Set Development Dust Ensure Environmental Epidemiology Environmental Exposure Environmental Health Environmental Impact Epidemiologist Epidemiology Epigenetic Process Exposure to Faculty Family Flame Retardants Funding Future Future Generations Goals Grant Growth Hair Health Housing Human Milk Infrastructure Institution Isoprostanes Laboratories Latino Life Life Cycle Stages Longevity Low income Lung diseases MicroRNAs Molecular Neighborhoods Obesity Outcome Participant Pesticides Population Positioning Attribute Public Health Schools Publications Publishing Research Research Personnel Resources Respiratory physiology Running Safety Salinas Valley Saliva Sampling Secure Specimen Statistical Data Interpretation United States National Institutes of Health Urine Validation Visit adipokines biobank career development cohort data archive data management data sharing deciduous tooth experience farm worker functional genomics improved laboratory facility member neurodevelopment parent grant participant retention postnatal preservation skills student training

项目摘要

ABSTRACT Since its inception in 1999, the CHAMACOS study is one of the longest running cohort studies examining the impact of early life environmental exposures on neurodevelopment, growth, and respiratory disease and the only one focused on low-income, Latino children in a farmworker population. We have collected extensive health, exposure, demographic, neighborhood, and regional data, as well as biological (e.g. blood, urine, breastmilk, hair, saliva, deciduous teeth) and environmental (e.g. dust, allergens) samples at multiple visits and have created a large biorepository with more than 300,000 samples stored for future use. We have used banked specimens and archived data to demonstrate relationships of pre- and postnatal exposures to pesticides, flame retardants, and other chemicals with poorer neurodevelopment, reduced lung function, obesity, and other outcomes. We have shown that environmental exposures affect a multitude of molecular mechanisms that influence health, such as PON1 enzymatic activity, adipokine and isoprostane levels, DNA methylation and miRNA expression. The CHAMACOS resources have supported multiple NIH, EPA, and non- federal grants and trainees, including collaborations with other institutions. With well over 150 publications, CHAMACOS is a successful and well-established environmental epidemiology cohort. The main goals of the parent grant (R24ES028529) were to maintain and improve the infrastructure required for management of this vast trove of data, the laboratory facilities to ensure the safety of hundreds of thousands of samples, and the effort to keep families engaged and participating in this long-running study. However, the School of Public Health (SPH) Biorepository and Children’s Environmental Health Laboratory, which house the biological and environmental specimens has experienced an unexpected shortfall of funding this year. The purpose of this administrative supplement is to provide additional critical funding to the SPH Biorepository. Supplement funds will be used to secure the position of early stage investigator, Dr. Karen Huen, who has been working with the CHAMACOS study for many years. Dr. Huen’s extensive skills and experience at the Children’s Environmental Health Laboratory and SPH Biorepository are crucial for the longevity of the Biorepository and the research that it supports. As an environmental and molecular epidemiologist, Dr. Huen has published extensively on the functional genomics of PON1 and on relationships of environmental exposures with epigenetic profiles in CHAMACOS children. For this supplement, she will support the main goals of the parent grant to maintain the vital functions of the SPH Biorepository. She will continue to train students, researchers, and new faculty members on essential skills for utilizing the invaluable specimens stored at the Biorepository from development and validation of molecular assays to statistical analysis of complex datasets. Further, securing her position will enable us to support her career development as she continues to pursue independent research paths and applies for additional NIH funding in the future.

抽象的自 1999 年启动以来，CHAMACOS 研究是运行时间最长的队列研究之一生命早期环境暴露对神经发育、生长和呼吸系统疾病的影响唯一一个关注农场工人中的低收入拉丁裔儿童的项目。我们收集了广泛的资料。健康、暴露、人口、邻里和区域数据，以及生物数据（例如血液、尿液、多次访视时采集母乳、头发、唾液、乳牙）和环境（例如灰尘、过敏原）样本创建了一个大型生物样本库，存储了超过 300,000 个样本以供将来使用。储存样本和存档数据以证明产前和产后接触的关系杀虫剂、阻燃剂和其他化学物质会导致神经发育不良、肺功能下降，我们已经证明，环境暴露会影响多种分子。影响健康的机制，例如 PON1 酶活性、脂肪因子和异前列烷水平、DNA CHAMACOS 资源支持多个 NIH、EPA 和非组织。联邦拨款和实习生，包括与其他机构的合作，出版了 150 多种出版物， CHAMACOS 是一个成功且完善的环境流行病学队列。母基金 (R24ES028529) 的主要目标是维护和改善基础设施管理如此庞大的数据宝库所需的实验室设施，以确保数百名人员的安全数千个样本，以及让家庭参与这项长期研究的努力。然而，公共卫生学院 (SPH) 生物样本库和儿童环境健康实验室，存放生物和环境标本的地方遭遇了意外的资金短缺今年这项行政补充的目的是为 SPH 提供额外的关键资金。生物储存库的补充资金将用于确保早期研究员凯伦博士的职位。 Huen 博士多年来一直致力于 CHAMACOS 研究。儿童环境健康实验室和 SPH 生物样本库的经验对于生物样本库的寿命及其支持的环境和分子研究。流行病学家 Huen 博士主要发表了有关 PON1 功能基因组学及其关系的文章对于这份补充资料，她将了解 CHAMACOS 儿童的环境暴露情况和表观遗传特征。她将支持家长拨款的主要目标，以维持 SPH 生物样本库的重要功能。继续对学生、研究人员和新教员进行基本技能培训，以利用这些宝贵的知识从分子测定的开发和验证到统计，样本均储存在生物样本库中此外，确保她的职位将使我们能够支持她的职业发展。她将继续追求独立研究道路，并在未来申请额外的 NIH 资助。