Advancing Alzheimer’s family caregiving interventions and research capacity in Vietnam

提高越南阿尔茨海默氏症家庭护理干预措施和研究能力

• 批准号: 10162468
• 负责人: WALTER LADSON HINTON
• 金额: $ 61.49万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162468
• 关键词: Address; Administrator; Aging; Alzheimer' s Disease; Alzheimer' s disease caregiver; Alzheimer' s disease related dementia; Applications Grants; Asia; Australia; Behavior; Brain Diseases; Caregiver Burden; Caregivers; Clinical Trials Design; Communities; Country; Coupled; Dementia; Demographic Transitions; Development; Dissemination and Implementation; Education; Elderly; Evaluation; Evidence based intervention; Family; Family Caregiver; Funding; Future; Goals; Grant; Health; Hospitals; Income; Institutes; Institution; Institutionalization; Intervention; Interview; Knowledge; Link; Mentors; Modeling; Modification; Nerve Degeneration; Outcome; Personal Satisfaction; Persons; Pharmaceutical Preparations; Policies; Policy Maker; Process; Public Health; Publications; Randomized; Randomized Controlled Trials; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Institute; Research Personnel; Resources; Scientist; Self Efficacy; Strategic Planning; Symptoms; Testing; Vietnam; anxiety symptoms; base; caregiver depression; caregiver interventions; caregiving; community setting; cost; depressive symptoms; efficacy testing; evidence base; experience; family caregiving; family support; feasibility testing; formative assessment; low and middle-income countries; novel; perceived stress; primary outcome; programs; secondary outcome; skills; trend

ABSTRACT A rapid demographic transition underway in low and middle-income countries (LMIC) will substantially increase the number of older adults suffering from Alzheimer’s disease and related dementias (ADRD) so that by 2030 more than 2/3 of all persons suffering from ADRD worldwide will reside in LMIC. Consequently, there is growing recognition in Vietnam and other LMIC that ADRD poses a major public health issue and the importance developing scientific evidence and research capacity to meet this challenge, including developing effective community-based support programs for family caregivers of persons with Alzheimer’s disease. Building on an established cross-national partnership between investigators in Vietnam and two HIC (US and Australia), the overall goals of this project are to test the efficacy of a community-based program to support Alzheimer’s family caregivers in Vietnam and to strengthen research capacity through development of a national Vietnam ADRD research network. To achieve these goals, we will build directly on the accomplishments of our planning grant. We now have in place a robust and effective collaborative relationship between investigators in HIC (US and Australia), the Vietnam National Geriatric Hospital (NGH), and the Vietnam Ministry of Health (MOH). Our research team has culturally adapted, implemented and tested the feasibility and preliminary efficacy of a community-based family ADRD caregiver intervention model (REACH VN) in a pilot cluster RCT of 60 family caregivers. Preliminary results of our pilot cluster RCT show strong evidence of both feasibility and preliminary efficacy. We now propose to test the efficacy of the REACH VN in a larger cluster RCT embedded in the community using a Stage III clinical trial design coupled with a formative evaluation using the RE-AIM framework to inform future implementation. We will also enhance ADRD research capacity more broadly in Vietnam by establishing a national network of researchers and creating a linked pilot grant program to provide mentoring and funding to meritorious scientists conducting ADRD research on family caregiving and other issues of high relevance to policy makers. Specific goals of this project are to 1) test the efficacy of REACH VN in Vietnam in cluster randomized controlled trial of 32 clusters (350 families), 2) identify key barriers and facilitators of REACH VN implementation in a community setting through a formative evaluation conducted in parallel with the cluster RCT, and 3) strengthen and build Vietnam national capacity in caregiving and other ADRD research through the creation of a network of researchers and a program of mentoring and pilot support.

抽象的 低收入和中等收入国家（LMIC）的人口快速过渡将 大大增加了患有阿尔茨海默氏病及相关的老年人的数量 痴呆症（ADRD），到2030年，全球遭受ADRD的所有人中有2/3以上 将居住在LMIC。因此，越南和其他LMIC越来越认识到 ADRD提出了一个重大的公共卫生问题，并重要的是开发科学证据， 应对这一挑战的研究能力，包括开发有效的基于社区的有效 为患有阿尔茨海默氏病患者的家庭护理人员提供支持计划。建立在一个 建立了越南调查人员与两个HIC之间的跨国伙伴关系（美国和 澳大利亚），该项目的总体目标是测试基于社区计划的效率 支持阿尔茨海默氏症在越南的家庭护理人员，并通过 越南国家ADRD研究网络的开发。为了实现这些目标，我们将 直接建立在我们的计划赠款的成就之上。我们现在已经有一个强大的 HIC（美国和澳大利亚），越南调查人员之间的有效合作关系 国家老年医院（NGH）和越南卫生部（MOH）。我们的研究 团队在文化上适应，实施和测试了A的可行性和初步效率 基于社区的家庭ADRD护理人员干预模型（REACH VN） 在60个家庭护理人员中。我们的飞行员群集RCT的初步结果显示了有力的证据 可行性和初步效率。我们现在建议测试覆盖范围VN的效率 在使用III期临床试验设计耦合的较大集群RCT中 使用RE-AIM框架进行形成性评估，以告知未来的实施。我们 还将通过建立国家 研究人员网络并创建链接的试点赠款计划，以提供指导和 资助有关家庭护理和其他其他研究的功绩科学家 与政策制定者高度相关的问题。该项目的具体目标是1）测试效率 越南越南的VN群集随机对照试验的32个簇（350个家庭），2） 确定在社区环境中实施VN实施的关键障碍和促进者 通过与簇RCT并行进行的形成性评估，3）加强和 通过创建越南在照料和其他ADRD研究方面建立越南国家的能力 研究人员网络以及心理和试点支持计划。