Behaviors related to Human Neural Activity during Experimental Vigilance to Pain

实验警惕疼痛时与人类神经活动相关的行为

• 批准号: 10159318
• 负责人: Fred Lenz
• 金额: $ 59.62万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159318
• 关键词: Accounting; Affect; Air; Anatomy; Arousal; Attention; Behavior; Behavioral; Brain; Characteristics; Complement; Computer software; Data; Detection; Development; Dimensions; Dorsal; Electrodes; Electroencephalography; Elements; Epilepsy; Event; Evoked Potentials; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Human; Implanted Electrodes; Inferior; Inferior frontal gyrus; Insula of Reil; Intractable Epilepsy; Investigation; Lasers; Lateral; Lead; Lesion; Magnetic Resonance Imaging; Measures; Medial; Mediating; Mental disorders; Movement Disorders; Neurosciences; Nociception; Occupations; Operative Surgical Procedures; Pain; Pain management; Painless; Parietal; Pathway Analysis; Patient Self-Report; Patients; Performance; Play; Prefrontal Cortex; Protocols documentation; Readiness; Research; Resolution; Risk; Role; Signal Transduction; Site; Source; Stimulus; Stroke; Structure; Surveys; Symptoms; Syndrome; Task Performances; Techniques; Testing; Time; Training; Vision; acute stroke; base; behavior change; behavior measurement; behavioral study; cingulate cortex; clinical pain; experience; experimental study; instrument; novel; pain processing; pain sensation; post stroke pain; psychologic; relating to nervous system; trait; vigilance

While abnormally increased Vigilance to pain is found in both ‘idiopathic’ and ‘nociceptive’ pain syndromes, the behavioral and neural characteristics of experimental Vigilance to pain are poorly understood. We propose to adapt a Continuous Performance Task (CPT) from Human Factors Research (e.g. air traffic controllers) to study Experimental Vigilance to pain. In our task, the subject pushes a button to indicate detection of painful target stimuli when they occur in a train of nontarget nonpainful stimuli, i.e. CPTpain. During a CPTpain, we propose to record and analyze local field potentials (LFP) directly from the brain through electrodes placed on the brain for the treatment of intractable epilepsy. This technique has unrivalled resolution but limited scope and so complements fMRI, which has lower resolution but surveys the whole brain. Our Premise is that: Errors and Arousal in a CPT with a painful target (CPTpain) mediate the behavioral and neural elements of Vigilance to pain, and affect Central Post Stroke Pain (CePSP). We propose to test the hypothesis that: Behaviors over time in a CPTpain are related to neural activations and interactions of modules in a network for Vigilance to pain, while changes in a behavior after a stroke identify the modules that are essential for that behavior, and for the development and symptoms of CePSP. Networks like this can be characterized by modules, and connections between modules as identified by their causal interactions. Our Preliminary Data shows that over time in a CPTpain detected nontargets and arousal are often associated with increased pain. These Data also suggest a Parietal EEG Signature for Vigilance to pain that is correlated with errors, suggesting that a Parietal module is involved in a distributed network for Vigilance to pain. Although these analyses of LFPs (or fMRI signals) do not prove that modules are essential for Vigilance to pain, a module can be identified as essential for a behavior if lesions of the module affect that behavior. Therefore, we propose to study stroke anatomy (by structural MRI) and behavioral measures in CPTpain in patients with acute strokes. We will use a software package developed at Hopkins for the analysis of lesions (LDDMM) with our long term collaborator, Dr. Hillis, who has broad experience with this package in studies of attention. Finally, our Preliminary Data demonstrates that Parietal structures are spared in patients with insular strokes who develop CePSP but are involved in patients with insular strokes who do not develop CePSP, which suggests a Parietal, Vigilance related mechanism for CePSP. The results of these proposed studies may frame testable hypotheses for the neuroscience of Vigilance to pain, and anatomically based therapies in the treatment of pain syndromes associated with Hypervigilance, and for an objective instrumented test of Vigilance to pain. The potential of analyses of networks for Vigilance to pain is suggested by the impact of network analyses on the neuroscience of vision, and on the development of novel surgical and stimulation therapies for the treatment of movement and psychiatric disorders.

尽管在“特发性”和“伤害感受”疼痛综合症中发现了绝对增加对疼痛的警惕性，但 对疼痛的实验警惕的行为和神经特征知之甚少。我们建议 适应人为因素研究（例如空中交通管制员）的连续绩效任务（CPT） 研究疼痛的实验警惕。在我们的任务中，受试者按下按钮以表明发现痛苦 当目标刺激发生在非目标非刺激的火车中时，即cptpain。 在CPTPAIN期间，我们建议直接从大脑记录和分析局部场电位（LFP） 通过放置在大脑上的电子，以治疗顽固性癫痫。该技术无与伦比 解决方案但范围有限，因此完成了fMRI，该功能磁共振成像的分辨率较低，但可以调查整个大脑。 我们的前提是：在具有痛苦目标（CPTPAIN）的CPT中的错误和唤醒可以介导行为和 警惕性的神经元素疼痛，并影响中风后疼痛（CEPSP）。我们建议测试 假设：随着时间的流逝，CPTPAIN的行为与模块的神经激活和相互作用有关 在警惕痛苦的网络中，而中风后行为的变化识别了模块 该行为以及CEPSP的发展和症状至关重要。这样的网络可以是 以模块为特征，以及由其因果相互作用确定的模块之间的连接。 我们的初步数据表明，随着时间的流逝，检测到的非目标和唤醒通常是 与疼痛增加有关。这些数据还表明，对疼痛保持警惕的顶端脑电图签名是 与错误相关，表明帕塞尔模块参与分布式网络，以保持警惕 尽管这些对LFP（或fMRI信号）的分析并未证明模块对于警惕至关重要 对于痛苦，如果模块的病变影响该行为，则可以将模块确定为行为必不可少的。 因此，我们建议研究中风解剖结构（通过结构MRI）和CPTPAIN的行为度量 急性中风的患者。我们将使用在霍普金斯开发的软件包进行病变分析 （LDDMM）与我们的长期合作者Hillis博士，他在此方面拥有广泛的经验 注意力。最后，我们的初步数据表明，在岛屿的患者中幸免了顶结构 开发CEPSP但参与没有发展CEPSP的岛状中风的患者， 这暗示了CEPSP的顶叶，警惕性的机制。 这些提出的研究的结果可能会构建可检验的假设，以了解警惕性的神经科学。 疼痛和基于解剖学的治疗疼痛综合症的疗法 并进行客观的疼痛警惕性测试。网络分析以保持警惕的潜力 网络分析对视力神经科学的影响以及对发展的影响提出了痛苦 用于治疗运动和精神疾病的新型外科手术和刺激疗法。