VENTROCAUDAL THALAMUS IN HUMAN PAIN

腹尾丘脑在人类疼痛中的作用

• 批准号: 6090869
• 负责人: Fred Lenz
• 金额: $ 36.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-10 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6090869
• 关键词: action potentials; chronic pain; clinical research; heat stimulus; human subject; mechanical pressure; neuromuscular disorder; thalamus

DESCRIPTION (Adapted from the Investigator's Abstract): The proposal is a competing continuation of a subproject in an earlier program project grant (P01 NS32386). The studies aim at continuing the examination of the role of the human somatosensory thalamus (Vc) in pain. The long-term objective is to define the role of thalamic activity in signaling thermal sensations and pain sensations using a combination of neurophysiological and psychophysical techniques. Single unit recordings in Vc are performed in chronic pain patients and patients with movement disorders. Recordings in the latter group are considered as generating control data. Aim 1 examines the properties of spike trains in Vc to painful and nonpainful mechanical and thermal stimuli, in movement disorder patients. They also plan on testing whether the spike train properties change with changes in stimulus intensity and as a function of attention. Aim 2 examines the sensations evoked by electrical stimulation within Vc in movement disorder patients. They will examine the sensations as a function of temporal properties of stimuli in an effort to distinguish between paresthesias, warm, cool, & pain perceptions, and to determine the relationship between temporal patterns and intensity perception, as well as relate the stimulus pattern to the characteristics of the neuronal discharge with the equivalent sensation. Aim 3 examines the same questions as in aims 1 & 2 in the Vc of chronic pain patients to differentiate changes in coding properties between the two groups of subjects.

描述（根据调查员的摘要改编）：该提案是一个 在较早的计划项目赠款中竞争持续副标题（P01 NS32386）。研究旨在继续研究 人类体感丘脑（VC）疼痛。长期目标是定义 丘脑活性在信号传导和疼痛中的作用 使用神经生理学和心理生理学的组合 技术。 VC中的单个单位记录在慢性疼痛患者中进行 和运动障碍的患者。后一组的录音是 被认为是生成控制数据。 AIM 1检查尖峰的特性 VC中的火车在痛苦和非机械和热刺激中， 运动障碍患者。他们还计划测试尖峰火车是否 特性随刺激强度的变化而变化，并且 注意力。 AIM 2检查电刺激引起的感觉 在运动障碍患者中的​​VC内。他们将把感觉视为 刺激的时间特性的功能，以区分 异常，温暖，凉爽和疼痛感，并确定关系 在时间模式和强度感知之间，并与 刺激模式与神经元放电的特征 等效感觉。 AIM 3检查了与目标1和2中相同的问题 慢性疼痛患者的VC以区分编码特性的变化 在两组受试者之间。