Intervention to reduce drug use and HIV incidence among high PrEP priority partnered YMSM

减少 PrEP 重点合作伙伴 YMSM 中吸毒和艾滋病毒发病率的干预措施

基本信息

批准号：
10152563
负责人：
Tyrel J Starks
金额：
$ 77.84万
依托单位：
HUNTER COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152563
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Adherence Age Agreement Attention Behavior Therapy Behavioral Biological Biological Assay Biological Markers Blood Centers for Disease Control and Prevention (U.S.)Collection Communication Couples Data Development Dose Drug Targeting Drug usage Education Epidemic Face Funding Future Gender Goals HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV risk Hair Heterosexuals Incidence Individual Infection Intervention Intervention Studies Interview Joints Link Logistics Measures Mediating Modeling Motivation Nature Participant Pharmaceutical Preparations Prevention Prevention strategy Provider Public Health Randomized Recommendation Reporting Research Research Personnel Risk Risk Behaviors Risk Reduction Behavior Sampling Sampling Biases Services Sex Behavior Sexual Health Spottings Structure of nail of finger Tenofovir United States United States National Institutes of Health Vulnerable Populations Work acceptability and feasibility attentional control base condomless anal sex control trial cost effectiveness implementation study effectiveness trial efficacy evaluation efficacy testing eligible participant experience follow up assessment group intervention health care settings innovation interest intervention effect men men who have sex with men motivational enhancement therapy multimodality novel pre-exposure prophylaxis prevent prevention service primary outcome psychoeducation recruit response service intervention sex skills skills training substance use theories transmission process uptake young man young men who have sex with men

项目摘要

Project Summary CDC recommendations identify MSM in non-monogamous relationships and those in relationships with an HIV positive partner as candidates for PrEP. Estimates suggest as many as 79% of new HIV infections among young MSM (YMSM; ages 18-29) are transmitted between main partners. Drug use is an established correlate of HIV transmission risk. For partnered men, relational factors (e.g., sexual agreements) contextualize drug use and both drug use and sexual agreements predict receptivity to PrEP. Together, these findings point to the need for integrated intervention services – targeting drug use and sexual health –tailored for partnered YMSM. Such services are essential to addressing the HIV epidemic in the US. In response, our team has developed a 4-session MI-based intervention targeting PrEP uptake/adherence, HIV TRB, and drug use among partnered YMSM. PARTNER (Prevention And Risk: Treatment with a New Emphasis on Relationships) is delivered to individual YMSM in relationships (not couples), which enhances the scalability of the proposed intervention. Our preliminary pilot work has established the acceptability and feasibility of PARTNER. The primary goal of the current study is to test the efficacy of PARTNER relative to an attention-matched educational control condition used in previously funded NIH studies with HIV-negative YMSM. We propose to recruit 240 HIV-negative partnered YMSM who report recent drug use and sexual behavior consistent with CDC guidance for PrEP candidacy into a randomized control trial. As part of a secondary aim, this project seeks to enhance the range of biological measures for PrEP adherence currently available. The field standard for assessing tenofovir metabolites is dried blood spot assay; however, fingernail assay has high acceptability and lower cost. We propose to validate fingernail samples for PrEP adherence by correlating results obtained from fingernail samples with dried blood spot data. The study team is led by Dr. Tyrel J. Starks (PI), a new investigator with substantial experience in the study of relationship factors associated with sexual health and MSM in relationships. He has collaborated on numerous projects examining the nature of sexual agreements and their association with substance use and HIV transmission risk behavior. He is supported by a study team which includes Dr. Jeffrey Parsons, the PI of multiple intervention studies targeting sexual health and substance use. He is also joined by Dr. Monica Gandhi, an expert in biological assessment for PrEP adherence who has pioneered the use of novel matrices in previous NIH- funded studies. The team brings extensive experience in behavioral intervention research, relationship research, and biomedical assessment.

项目摘要 CDC建议在非一体性关系中确定MSM，以及与艾滋病毒积极伴侣作为候选人的关系。估计表明很多由于年轻MSM中79％的新艾滋病毒感染（YMSM； 18-29岁）是在之间传播的主要合作伙伴。毒品使用是艾滋病毒传播风险的建立相关性。对于合伙人，关系因素（例如，性协议）将吸毒和吸毒和使用的情况与性协议可以预测准备的接受能力。这些发现一起表明需要综合干预服务 - 针对毒品使用和性健康 - 旨在合作 YMSM。这种服务对于解决美国的艾滋病毒流行至关重要。作为回应，我们的团队已经开发了针对PREP的4条基于MI的干预措施合作YMSM的摄取/依从性，HIV TRB和药物使用。合作伙伴（预防风险：以新的强调关系的治疗）已交付给单个YMSM 关系（不是夫妻），可以增强提出的干预措施的可扩展性。我们的初步的试点工作已经确定了合作伙伴的可接受性和可行性。主要本研究的目标是测试伴侣相对于注意力匹配的效率在先前资助的NIH研究中，使用HIV阴性YMSM使用的教育控制条件。我们建议招募240名HIV阴性合作的YMSM，他们报告了最近使用药物的使用和性行为与CDC指南一致，以准备候选者进入随机对照审判。作为次要目标的一部分，该项目旨在增强生物学的范围目前可用的准备依从性措施。评估Tenofovir的现场标准代谢产物是干斑测定的；但是，指甲分析具有很高的可接受性和较低的成本。我们建议通过关联结果来验证指甲样品以依从性从带有干血点数据的指甲样品中获得。研究团队由具有丰富经验的新调查员Tyrel J. Starks（PI）领导在研究与性健康和关系中的关系因素的研究中。他已经合作研究了许多项目，以研究性协议的性质及其与药物使用和HIV传播风险行为相关联。他得到了一项研究的支持包括杰弗里·帕森斯博士（Jeffrey Parsons）的团队，针对性的多个干预研究的PI 健康和物质使用。他还加入了生物学专家Monica Gandhi博士评估依从性的依从性，他在先前的NIH-中率先使用新物质资助研究。该团队在行为干预研究中带来丰富的经验，关系研究和生物医学评估。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Psychosocial and Culturally-Specific Factors Related to Intimate Partner Violence Victimization among a Sample of Latino Sexual Minority Cis Men in the U.S.

DOI：
10.1177/08862605211072167
发表时间：
2022-12
期刊：
JOURNAL OF INTERPERSONAL VIOLENCE
影响因子：
2.5
作者：
Robles, Gabriel;Bosco, Stephen C.;Cardenas, Iris;Hostetter, Joletta;Starks, Tyrel J.
通讯作者：
Starks, Tyrel J.

Keeps me awake at night: The potential of the COVID-19 pandemic to affect sleep quality among sexual minority men in the U.S.A.