Evaluating the efficacy of annual CHTC retesting among male couples at high risk of HIV infection

评估 HIV 感染高危男性夫妇每年进行 CHTC 重新检测的效果

• 批准号: 10700394
• 负责人: Tyrel J Starks
• 金额: $ 10.76万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700394
• 关键词: 4-hydroxybutyric acid; AIDS prevention; Accounting; Address; Adherence; Age; Agreement; Amphetamines; Appointment; Bisexual; COVID-19; Cannabis; Chlamydia Infections; Cocaine; Communication; Consent; Counseling; Couples; Data; Drug usage; Enrollment; Feedback; Gays; Gonorrhea; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human immunodeficiency virus test; Individual; Infection; Intervention; Investments; Ketamine; Link; Measures; Mediating; Mediator; Modeling; Nature; Nitrates; Outcome; Parents; Participant; Population; Prevention; Prevention strategy; Protocols documentation; Public Health; Randomized; Recommendation; Recording of previous events; Reporting; Research; Rest; Risk; Risk Behaviors; Sampling; Syphilis; Testing; Time; Training; United States National Institutes of Health; aged; binge drinking; condomless anal sex; coping; design; ecstasy; efficacy evaluation; efficacy testing; emerging adult; follow up assessment; follow-up; high risk; implementation research; intervention effect; male couples; men; men who have sex with men; motivational enhancement therapy; post intervention; pre-exposure prophylaxis; response; sex; sexual HIV transmission; sexual minority men; skills; substance use; theories; transmission process; uptake

Project Summary Sexual minority men (SMM), including gay, bisexual, and other men who have sex with men, account for 69% of new HIV infections in the US. Primary partnerships have been linked to up to as many as 68% of new HIV infections among SMM. This rate is highest among emerging adult SMM (aged 18-29), where estimates suggest 79% to 84% of HIV infections are transmitted by primary partners. In response to the concerns posed by primary partner transmission, couples HIV testing and counseling (CHTC) has been acknowledged as an established HIV prevention strategy. During CHTC, couples complete HIV testing and prevention planning together. Current CHTC guidance includes the recommendation that all couples routinely retest every 6 to 12 months. Despite the standard nature of this retesting recommendation, no study has empirically evaluated the effects of CHTC retesting. This competitive revision capitalizes on NIH investment in the parent study (DA050508) to obtain the first outcomes data on annual CHTC retesting. DA050508 is currently enrolling 240 male couples living in the US in which at least one partner: is age 17 to 29; is HIV-negative; and reports recent (past 30 days) drug use (e.g., cannabis, cocaine/crack, amphetamines, ecstasy, gamma hydroxybutyric acid, ketamine, or nitrates), and recent (past 3 months) sexual HIV transmission risk behavior. As part of their participation in DA050508, all couples complete a CHTC session after baseline. They subsequently complete follow-up assessments at 3, 6, 9, and 12-months post- baseline. The purpose of this revision is to evaluate the benefits associated with CHTC resting. After their 12- month follow-up, those participants who remain in the same relationship they were in at the time of their baseline will be offered the opportunity to continue in the components proposed in this revision. Those who consent will be randomized to either complete a second session of CHTC or to a comparison condition in which both partners receive a routine individual HIV test. HIV positive partners in serodiscordant couples randomized to the control condition will receive information about ART adherence and U=U. Given potential attrition and rates of relationship dissolution, we anticipate randomizing 200 couples (80% of the original sample). Follow-up assessments will be conducted 3 and 6 months after retesting (15 and 18 months after the participants’ original baseline appointment).

项目摘要 性少数民族（SMM），包括同性恋，双性恋和其他与男人发生性关系的男人 在美国有69％的新艾滋病毒感染。主要合作伙伴关系已与多达68％ SMM中的新艾滋病毒感染。在新兴成人SMM中，此速率最高（18-29岁） 估计表明，艾滋病毒感染的79％至84％是由主要伴侣传播的。回应 主要合作伙伴传播，夫妻艾滋病毒测试和咨询（CHTC）的关注 被公认为已建立的艾滋病毒预防策略。在CHTC期间，夫妻完成HIV测试和 预防计划。 当前的CHTC指南包括建议所有夫妇通常每6至12一次重新测试 月份。尽管这项重新测试建议的标准性质，但尚无验证评估 CHTC重新测试的影响。这项具有竞争性的修订资源是在父母研究中的NIH投资上 （DA050508）获取有关年度CHTC重新测试的第一个结果数据。 DA050508目前正在美国招募240对居住在美国的男性夫妇，其中至少一个合作伙伴是： 17至29;是艾滋病毒阴性；并报告最近（过去30天）使用药物（例如大麻，可卡因/裂纹， 苯丙胺，摇头丸，伽马羟基丁酸，氯胺酮或硝酸盐）以及最近（过去3个月）性 HIV传播风险行为。作为他们参与DA050508的一部分，所有夫妇都完成了CHTC 基线后的会话。他们随后在3、6、9、9和12个月后完成随访评估。 基线。 此修订的目的是评估与CHTC休息相关的收益。 12-之后 一个月的随访，那些保持与他们之间相同关系的参与者 将为基线提供机会继续进行此修订中提议的组件。那些人 同意将随机分配以完成第二届CHTC或比较条件 双方都将接受例行的个人艾滋病毒测试。艾滋病毒的阳性伴侣在夫妻夫妇中 随机分配到控制条件将接收有关ART依从性和U = U的信息。具有潜力 关系解散的流失和速率，我们预计将随机化200对夫妇（占原始的80％ 样本）。后续评估将在重新测试后3和6个月进行（15和18个月后 参与者的原始基线预约）。

项目成果

A full-factorial randomized controlled trial of adjunct couples HIV testing and counseling components addressing drug use and communication skills among sexual minority male couples.

• DOI: 10.1186/s12889-021-12208-3
• 发表时间: 2021-11-24
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Starks TJ;D Kyre K;B Cowles C;Castiblanco J;Washington C;N Parker J;M Kahle E;Stephenson R
• 通讯作者: Stephenson R