Microbiome Function in Atopic Dermatitis

微生物组在特应性皮炎中的功能

• 批准号: 10152517
• 负责人: Richard L Gallo
• 金额: $ 47.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10152517
• 关键词: 18 year old; 6 year old; Adult; Age; Anti-Inflammatory Agents; Antibiotic Resistance; Antibiotics; Antigen-Presenting Cells; Atopic Dermatitis; Bacteria; Cells; Characteristics; Child; Childhood; Chronic; Chronic Disease; Clinical Research; Cutaneous; Defect; Dermal; Dermis; Development; Disease; Dose; Elements; Environment; Epithelial Cells; Frequencies; Functional disorder; Goals; Growth; Human; Immune Targeting; Immune response; Immune system; Immunosuppression; Immunosuppressive Agents; Immunotherapy; Incidence; Inflammation; Inflammatory; Innovative Therapy; Interruption; Intervention; Lead; Lesion; Lymphocyte; Measures; Microbe; Mission; Mupirocin; Myelogenous; Nature; Oral; Patients; Peptide Hydrolases; Peptides; Phenotype; Play; Population; Recurrence; Research; Severities; Shapes; Skin; Staphylococcus aureus; Staphylococcus hominis; Surface; Testing; Topical Antibiotic; Topical application; Toxin; Triamcinolone; Work; antimicrobial; base; beneficial microorganism; cohort; dysbiosis; fighting; improved; innovation; insight; keratinocyte; mast cell; member; microbial; microbiome; microbiome therapeutics; novel therapeutic intervention; pediatric patients; prototype; response; side effect; skin barrier; skin disorder; skin lesion; skin microbiome; success

Summary/Abstract Atopic dermatitis (AD) is a common inflammatory skin disease. Recent observations strongly suggest that the abnormal microbiome present on the skin of subjects with AD is a major factor that influences the severity and chronic nature of this disorder. In particular, Staphylococcus aureus promotes epidermal barrier dysfunction and exacerbates the local and systemic immune response. In healthy subjects, beneficial members of the skin microbiome act to limit the growth of Staphylococcus aureus but these beneficial bacterial strains are missing on adults with AD. This project seeks to understand why adults with AD lack beneficial bacterial strains by study of the survival of a prototype strain of Staphylococcus hominis on AD skin. Interventions to improve its survival will be tested, and application in the pediatric AD population will be evaluated. Overall, successful completion of the proposed aims of this ADRN Clinical Research Center will advance understanding of AD and provide essential information to permit development of an innovative new therapeutic approach based on targeted microbiome therapy.

摘要/摘要 特应性皮炎（AD）是一种常见的炎症性皮肤病。最近的观察强烈表明 AD 患者皮肤上存在的异常微生物组是影响 AD 患者皮肤的主要因素 这种疾病的严重程度和慢性性质。特别是金黄色葡萄球菌可促进表皮屏障 功能障碍并加剧局部和全身免疫反应。对于健康受试者，有益 皮肤微生物组的成员可以限制金黄色葡萄球菌的生长，但这些有益细菌 患有 AD 的成人中缺少菌株。该项目旨在了解为什么患有 AD 的成年人缺乏有益的 通过研究人型葡萄球菌原型菌株在 AD 皮肤上的存活情况来确定细菌菌株。 将测试提高其生存率的干预措施，并将在儿科 AD 人群中应用 评价。总体而言，成功完成该 ADRN 临床研究中心的拟议目标将 促进对AD的理解并提供必要的信息以允许开发创新的新产品 基于靶向微生物组治疗的治疗方法。