The functional significance of ASPM, responsible gene for human microcephaly, in the activation of adult neural stem cells - a new approach to brain anti-aging

ASPM（人类小头畸形的负责基因）在成体神经干细胞激活中的功能意义——大脑抗衰老的新方法

• 批准号: 15K01722
• 负责人: Tando So
• 金额: $ 3.08万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01722/
• 关键词: 加齢・老化; ASPM; 神経幹細胞; MRI; 行動表現型

项目成果

Longitudinal diffusion tensor imaging revealed nerve fiber alterations in Aspm mutated microcephaly model mice

纵向扩散张量成像显示 Aspm 突变小头畸形模型小鼠的神经纤维改变

• 发表时间: 2018
• 作者: Ogi H; Nitta N; Shibata S; T;o S; Fjimori A; Aoki I; Fushiki S; Itoh K
• 通讯作者: Itoh K

Longitudinal Diffusion Tensor Imaging Revealed Nerve Fiber Alterations in Aspm Mutated Microcephaly Model Mice

纵向扩散张量成像揭示 Aspm 突变小头畸形模型小鼠的神经纤维改变

• DOI: 10.1016/j.neuroscience.2017.12.012
• 发表时间: 2018
• 影响因子: 3.3
• 作者: Ogi Hiroshi;Nitta Nobuhiro;T;o So;Fujimori Akira;Aoki Ichio;Fushiki Shinji;Itoh Kyoko
• 通讯作者: Itoh Kyoko

Hippocampal adult neurogenesis is perturbed in microcephaly model mice with aging

随着衰老，小头畸形模型小鼠的海马成年神经发生受到干扰

• 发表时间: 2018
• 作者: Takahashi H ; Fujimori A ; T;o S ; Mori M ; Fushiki S ; Itoh K
• 通讯作者: Itoh K

Longitudinal diffusion tensor imaging and neuropathology revealed nerve fiber alterations in hereditary microcephaly model mice

纵向扩散张量成像和神经病理学揭示遗传性小头畸形模型小鼠的神经纤维改变

• 发表时间: 2018
• 作者: Ogi H; Nitta N; T;o S; Fujimori A; Aoki I; Fushiki S; Itoh K
• 通讯作者: Itoh K