NATURAL HISTORY OF AIDS IN HOMOSEXUAL MEN

男同性恋者艾滋病的自然史

• 批准号: 2296795
• 负责人: CHARLES R RINALDO
• 金额: $ 3.99万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2296795
• 关键词: NATURAL; HISTORY; AIDS; HOMOSEXUAL; MEN

The general objectives of the MAC study are: (a) To better understand the natural history of HIV infection (b) To determine the risk factors, and appropriate interventions to limit the spread of the disease and to (c) Characterize any biologic or environmental factors which will alter the natural history of the disease (e.g, either limit or accelerate the morbidity and mortality associated with infection) in this population. The specific objectives of the MAC study are: (1) To continue to study the natural history of HIV infection among a population of homosexual men who have been enrolled in the MAC study since 1983, by specifically collecting demographic, sociocultural and behavioral selfreport data and statistically correlating this data with physical examination findings, HIV antibody status, immunologic and blood chemistry and hematology parameters and the presence of antibodies to other viruses. (2) To determine the rate of disease progression of infection by comparing laboratory findings (HLAtype, CBC, SMA12), immunologic parameters (by flow cytometry), physical examinations, neuropsychiatric evaluations and electromechanical findings (EEG, EKG, MRI, CAT, nerve conduction studies, radiographic findings) with behavioral events. (3) To determine the rate of seroconversion among sexually homosexual men as well as determine those behaviors which may alter the rate of seroconversion. (4) To determine the nature and extent of covirus infections among sexually active homosexual men.

MAC 研究的总体目标是： (a) 更好地了解艾滋病毒感染的自然史 (b) 确定风险因素和适当的干预措施 以限制疾病的传播并 (c) 描述任何生物或环境因素，这些因素将 改变疾病的自然史（例如，限制或 加速与感染相关的发病率和死亡率） 在这个人群中。 MAC研究的具体目标是： （一）继续研究HIV感染的自然史 在已登记的男同性恋群体中 自 1983 年以来的 MAC 研究，通过专门收集人口统计数据， 社会文化和行为自我报告数据和统计 将这些数据与体检结果、艾滋病毒相关联 抗体状态、免疫学、血液化学和血液学 参数以及其他病毒抗体的存在。 (2) 确定感染的疾病进展率 比较实验室检查结果（HLAtype、CBC、SMA12）， 免疫学参数（通过流式细胞术）、物理参数 检查、神经精神评估和机电 结果（EEG、EKG、MRI、CAT、神经传导研究、 放射照相结果）与行为事件。 (3) 测定性人群血清转化率 同性恋男性以及确定那些可能的行为 改变血清转化率。 (4)确定冠状病毒感染的性质和程度 性活跃的男同性恋者中。