Multicenter AIDS Cohort Study

多中心艾滋病队列研究

基本信息

批准号：
7919064
负责人：
CHARLES R RINALDO
金额：
$ 90.12万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-12 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7919064
关键词：
AIDS/HIV problem Accounting Acquired Immunodeficiency Syndrome Adherence Adverse effects Affect Age Alcohol or Other Drugs use Anti-Retroviral Agents Behavioral Biological Cardiovascular Diseases Cardiovascular system Clinical Cohort Studies Combined Modality Therapy Companions Competence Data Diabetes Mellitus Disease Disease Progression Dyslipidemias Epidemiology Exposure to Genetic Glucose HIV HIV Infections HIV drug resistance HIV therapy Health Hepatitis B Virus Hepatitis C virus Highly Active Antiretroviral Therapy Human immunodeficiency virus test Immune Immunotherapeutic agent Incidence Individual Infection Instruction Insulin Intervention Investigation Kidney Diseases Knowledge Laboratories Lipids Lipodystrophy Liver Function Tests Liver diseases Long-Term Effects Longitudinal Studies Maintenance Malignant Neoplasms Mission Natural History Neoplasms Neurocognitive Outcome Participant Pathogenesis Pattern Population Public Health Recording of previous events Renal function Research Risk Behaviors Risk Factors Serum Specimen Substance abuse problem T-Lymphocyte Subsets Testing Therapeutic Treatment Effectiveness Treatment Protocols U-Series Cooperative Agreements United States National Institutes of Health Vaccines Viral Load result age effect antiretroviral therapy cohort follow-up improved insight men men who have sex with men physical process prevent programs prophylactic psychologic repository response therapy development transmission process

项目摘要

This application is Part B of a proposal for a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the Part A composite proposal that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS is to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE (See instructions): As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.

本申请是匹兹堡部分竞争更新提案的 B 部分多中心艾滋病队列研究 (MACS) 合作协议 (1UO1-AI-35041)， A 部分 CAMACS 正在提交的综合提案。 MACS 始于 1983 年，是一个纵向组织男男性行为者 (MSM) 艾滋病自然史的研究。此请求是为了额外为匹兹堡 MSM 群体的临床随访和实验室检测提供五年支持 MACS。匹兹堡 MACS 的总体目标是实现 A 部分主 MACS 的具体目标应用程序，并在匹兹堡当地进行专门研究，以增强我们的流行病学和发病机制与治疗干预以及免疫治疗和预防开发相关的知识疫苗。我们的具体目标是确定艾滋病毒感染的长期自然史和治疗史。 MSM，描述对 HIV 治疗的反应，包括心理和行为预测因素，检查艾滋病毒和长期艾滋病毒治疗对脂肪营养不良、糖尿病、心血管疾病的影响疾病、肝脏疾病、恶性肿瘤、神经认知功能、药物滥用、肾脏疾病等结果，评估衰老对 HIV 临床过程和 HIV 治疗的影响，检查相互作用宿主遗传学和 HIV 之间的关系，定义 HIV 发病机制，描述 HIV 相关癌症的特征，包括识别风险因素，确定影响艾滋病毒传播和疾病的社会行为因素进展，描述伴随感染及其对 HIV 疾病进展的影响，检查药物滥用对抗逆转录病毒治疗效果的影响，保持纵向收集流行病学数据和生物标本存储库作为促进自然历史和发病机制研究，在匹兹堡 MACS 中进行 MSM 的临床和实验室测试，包括 T 细胞子集、抗 HIV 抗体、HIV 病毒载量、乙型肝炎病毒和丙型肝炎病毒检测、血脂/胰岛素/血糖水平、肝功能测试、肾功能和心血管研究。这项研究与 NIH 的使命是治愈和预防艾滋病毒感染和艾滋病。相关性（参见说明）：作为 MACS 研究联盟的一部分，匹兹堡 MACS 提议继续其 25 年的科学研究调查艾滋病毒/艾滋病的自然史。这项研究提供了对艾滋病毒机制的深入了解感染、艾滋病毒治疗的效果以及艾滋病毒治疗和预防疫苗的开发感染。它与 NIH 的艾滋病毒/艾滋病公共卫生计划高度相关。